Antibacterial efficiency enhancement of gentamicin sulfate encapsulated CuS nanoparticles
The use of engineered semiconductor nanomaterials to address multi-drug resistance in bacteria has gained attention. In this study, an environmentally friendly cost-effective biological approach to synthesize copper sulfide nanoparticles (CuS-NPs) is reported. The CuS-NPs and the antibiotic Gentam...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2022-10-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | https://sjst.psu.ac.th/journal/44-5/25.pdf |
| _version_ | 1797839744278724608 |
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| author | Padikkamannil Abishad Namratha Keerthiraj Srinath B. S. Jayashankar Madayya Jess Vergis Byrappa Kullaiya |
| author_facet | Padikkamannil Abishad Namratha Keerthiraj Srinath B. S. Jayashankar Madayya Jess Vergis Byrappa Kullaiya |
| author_sort | Padikkamannil Abishad |
| collection | DOAJ |
| description | The use of engineered semiconductor nanomaterials to address multi-drug resistance in bacteria has gained attention. In
this study, an environmentally friendly cost-effective biological approach to synthesize copper sulfide nanoparticles (CuS-NPs) is
reported. The CuS-NPs and the antibiotic Gentamicin Sulfate (GS) at the concentration of 40 μg/mL exhibit significant
synergistic inhibition against several human pathogens (E. coli, Salmonella typhi, Klebsiella pneumoniae, Staphylococcus
aureus, and Bacillus subtilis). The effective release of antibiotic and less frequent administration are therapeutic advantages. The
drug entrapment and loading capacity of synthesized CuS nanoparticles (CuS-NP) were recorded as 61% and 39%, respectively.
Additionally, a promising activity of the mycosynthesized CuS-NP is an increased cytotoxicity against MDA-MB-231 breast
cancer cell line, as indicated by the estimated IC50 value.
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| first_indexed | 2024-04-09T16:02:00Z |
| format | Article |
| id | doaj.art-9bc93357f8334726b49672343025e72a |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-04-09T16:02:00Z |
| publishDate | 2022-10-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-9bc93357f8334726b49672343025e72a2023-04-25T09:50:38ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952022-10-014451345135210.14456/sjst-psu.2022.175Antibacterial efficiency enhancement of gentamicin sulfate encapsulated CuS nanoparticlesPadikkamannil Abishad0Namratha Keerthiraj1Srinath B. S.2Jayashankar Madayya3Jess Vergis4Byrappa Kullaiya5Center for Material Science and Technology, University of Mysore, Mysuru, Karnataka, 570005 IndiaCentre for Advanced Studies in Precambrian Geology, Mysore, Karnataka 570006 IndiaDepartment of Studies and Research in Microbiology, Mangalore University, Mangaluru, Karnataka, 574199 IndiaDepartment of Studies and Research in Microbiology, Mangalore University, Mangaluru, Karnataka, 574199 IndiaDepartment of Veterinary Public Health, College of Veterinary and Animal Sciences, Kerala Veterinary and Animal Sciences University, Pookode, Wayanad, 673576 IndiaCentre for Research and Innovations, BGS Institute of Technology, Adichunchanagiri University, Nagara, Mandya, Karnataka, 571448 IndiaThe use of engineered semiconductor nanomaterials to address multi-drug resistance in bacteria has gained attention. In this study, an environmentally friendly cost-effective biological approach to synthesize copper sulfide nanoparticles (CuS-NPs) is reported. The CuS-NPs and the antibiotic Gentamicin Sulfate (GS) at the concentration of 40 μg/mL exhibit significant synergistic inhibition against several human pathogens (E. coli, Salmonella typhi, Klebsiella pneumoniae, Staphylococcus aureus, and Bacillus subtilis). The effective release of antibiotic and less frequent administration are therapeutic advantages. The drug entrapment and loading capacity of synthesized CuS nanoparticles (CuS-NP) were recorded as 61% and 39%, respectively. Additionally, a promising activity of the mycosynthesized CuS-NP is an increased cytotoxicity against MDA-MB-231 breast cancer cell line, as indicated by the estimated IC50 value. https://sjst.psu.ac.th/journal/44-5/25.pdfgentamicin sulfatecus nanoparticlesmyconanotechnologybiosynthesiscytotoxicity |
| spellingShingle | Padikkamannil Abishad Namratha Keerthiraj Srinath B. S. Jayashankar Madayya Jess Vergis Byrappa Kullaiya Antibacterial efficiency enhancement of gentamicin sulfate encapsulated CuS nanoparticles Songklanakarin Journal of Science and Technology (SJST) gentamicin sulfate cus nanoparticles myconanotechnology biosynthesis cytotoxicity |
| title | Antibacterial efficiency enhancement of gentamicin sulfate encapsulated CuS nanoparticles |
| title_full | Antibacterial efficiency enhancement of gentamicin sulfate encapsulated CuS nanoparticles |
| title_fullStr | Antibacterial efficiency enhancement of gentamicin sulfate encapsulated CuS nanoparticles |
| title_full_unstemmed | Antibacterial efficiency enhancement of gentamicin sulfate encapsulated CuS nanoparticles |
| title_short | Antibacterial efficiency enhancement of gentamicin sulfate encapsulated CuS nanoparticles |
| title_sort | antibacterial efficiency enhancement of gentamicin sulfate encapsulated cus nanoparticles |
| topic | gentamicin sulfate cus nanoparticles myconanotechnology biosynthesis cytotoxicity |
| url | https://sjst.psu.ac.th/journal/44-5/25.pdf |
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