Modulation of LDL receptor expression and promoter methylation in HepG2 cells treated with a Corylus avellana L. extract

Modulation of LDL receptor expression and promoter methylation in HepG2 cells treated with a Corylus avellana L. extract

The aim of our study was to evaluate the impact of an ethanolic extract of C. avellana on the molecular pathway(s) regulating the low-density lipoprotein receptor (LDLR) in HepG2 cells, mainly in terms of epigenetics. We demonstrated that viability, proliferation and cell cycle distribution were not...

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Bibliographic Details
Main Authors: Barbara Benassi, Chiara Santi, Stefania Santangeli, Maria Giuseppa Grollino, Giuseppe Raschellà, Loretta Bacchetta, Francesca Pacchierotti
Format: Article
Language:English
Published: Elsevier 2019-02-01
Series:Journal of Functional Foods
Subjects:
Hazelnut
Corylus avellana L.
LDLR
Epigenetics
DNA methylation
HepG2
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464618306534

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