Chronic Epstein-Barr viral load carriage after pediatric organ transplantation
Epstein-Barr virus (EBV) infection and EBV-associated post-transplant lymphoproliferative disorder (EBV/PTLD) is one of the most devastating complications occurring in pediatric solid organ transplant (SOT) recipients. Observations of SOT recipients undergoing serial EBV monitoring to inform reducti...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-01-01
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| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1335496/full |
| _version_ | 1797338435930816512 |
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| author | Masaki Yamada Sharon F. Chen Michael Green |
| author_facet | Masaki Yamada Sharon F. Chen Michael Green |
| author_sort | Masaki Yamada |
| collection | DOAJ |
| description | Epstein-Barr virus (EBV) infection and EBV-associated post-transplant lymphoproliferative disorder (EBV/PTLD) is one of the most devastating complications occurring in pediatric solid organ transplant (SOT) recipients. Observations of SOT recipients undergoing serial EBV monitoring to inform reduction of immune suppression to prevent EBV-/PTLD has identified patients who maintain chronic high EBV load (CHL) in their blood. The CHL carrier state has been seen more commonly in pediatric compared to adult transplant recipients. Some but not all CHL may progress to EBV/PTLD. However, little is known regarding the biology of this CHL carrier state and the optimal clinical approach to CHL has not been established. This review summarizes the current knowledge and evidence of chronic high EBV load and introduces commonly adopted approaches from experts in this field. |
| first_indexed | 2024-03-08T09:31:10Z |
| format | Article |
| id | doaj.art-9bca5d63c9c4441f98fd080d3b03161d |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-03-08T09:31:10Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-9bca5d63c9c4441f98fd080d3b03161d2024-01-31T04:25:59ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-01-011210.3389/fped.2024.13354961335496Chronic Epstein-Barr viral load carriage after pediatric organ transplantationMasaki Yamada0Sharon F. Chen1Michael Green2National Center for Child Health and Development (NCCHD), Tokyo, JapanDepartment of Pediatrics, Stanford University, Palo Alto, CA, United StatesDepartments of Pediatrics and Surgery, University of Pittsburgh, Pittsburgh, PA, United StatesEpstein-Barr virus (EBV) infection and EBV-associated post-transplant lymphoproliferative disorder (EBV/PTLD) is one of the most devastating complications occurring in pediatric solid organ transplant (SOT) recipients. Observations of SOT recipients undergoing serial EBV monitoring to inform reduction of immune suppression to prevent EBV-/PTLD has identified patients who maintain chronic high EBV load (CHL) in their blood. The CHL carrier state has been seen more commonly in pediatric compared to adult transplant recipients. Some but not all CHL may progress to EBV/PTLD. However, little is known regarding the biology of this CHL carrier state and the optimal clinical approach to CHL has not been established. This review summarizes the current knowledge and evidence of chronic high EBV load and introduces commonly adopted approaches from experts in this field.https://www.frontiersin.org/articles/10.3389/fped.2024.1335496/fullpediatricssolid organ transplantationEpstein-Barr virusPTLDchronic high load carrier |
| spellingShingle | Masaki Yamada Sharon F. Chen Michael Green Chronic Epstein-Barr viral load carriage after pediatric organ transplantation Frontiers in Pediatrics pediatrics solid organ transplantation Epstein-Barr virus PTLD chronic high load carrier |
| title | Chronic Epstein-Barr viral load carriage after pediatric organ transplantation |
| title_full | Chronic Epstein-Barr viral load carriage after pediatric organ transplantation |
| title_fullStr | Chronic Epstein-Barr viral load carriage after pediatric organ transplantation |
| title_full_unstemmed | Chronic Epstein-Barr viral load carriage after pediatric organ transplantation |
| title_short | Chronic Epstein-Barr viral load carriage after pediatric organ transplantation |
| title_sort | chronic epstein barr viral load carriage after pediatric organ transplantation |
| topic | pediatrics solid organ transplantation Epstein-Barr virus PTLD chronic high load carrier |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1335496/full |
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