| Summary: | <p><strong>Objective </strong> To investigate the value of YKL-40 in diagnosing Parkinson's disease (PD). <strong>Methods</strong> Blood samples of 63 PD patients and 60 healthy controls were collected in this study. YKL-40 levels were measured by enzyme-linked immunosorbent assay (ELISA). Unified Parkinson's Disease Rating Scale (UPDRS) and Hoehn-Yahr (H-Y) stage were used to assess the ability of daily life, motor funciton and disease severity of PD patients. Then the correlation between YKL-40 and motor symptoms of PD was analyzed by Spearman's rank correlation analysis. Receiver operating characteristic (ROC) curve was used to investigate the sensitivity and specificity of YKL-40 in diagnosing PD. <strong>Results </strong> The YKL-40 levels in PD patients were (3.72 ± 0.10) ng/ml, which was significantly higher than that in healthy controls [(2.92 ± 0.18) ng/ml; <em>t</em> = 4.141, <em>P</em> = 0.000]. Spearman analysis indicated that there was positive correlation between YKL-40 and UPDRS scores (<em>r<sub>s</sub></em> = 0.872, <em>P</em> = 0.000), and between YKL-40 and H-Y stage (<em>r<sub>s</sub></em> = 0.704, <em>P</em> = 0.000). ROC curve indicated that the sensitivity and specificity of YKL-40 in diagnosing PD was 95.26% and 73.34% , respectively. <strong>Conclusions </strong> There was a correlation between YKL-40 and the severity of PD, so YKL-40 can be used as a biomarker in diagnosing PD.</p><p> </p><p>doi: 10.3969/j.issn.1672-6731.2014.12.014</p>
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