The Path from Nasal Tissue to Nasal Mucosa on Chip: Part 2—Advanced Microfluidic Nasal In Vitro Model for Drug Absorption Testing

The Path from Nasal Tissue to Nasal Mucosa on Chip: Part 2—Advanced Microfluidic Nasal In Vitro Model for Drug Absorption Testing

The nasal mucosa, being accessible and highly vascularized, opens up new opportunities for the systemic administration of drugs. However, there are several protective functions like the mucociliary clearance, a physiological barrier which represents is a difficult obstacle for drug candidates to ove...

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Bibliographic Details
Main Authors: Eugen Viktor Koch, Sebastian Bendas, Kristina Nehlsen, Tobias May, Stephan Reichl, Andreas Dietzel
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Pharmaceutics
Subjects:
organ on chip
microfluidics
nasal mucosa
nasal drug administration
permeation test
mucociliary clearance
Online Access:https://www.mdpi.com/1999-4923/15/10/2439

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