Oxazepam and cognitive reappraisal: A randomised experiment.
<h4>Background</h4>Cognitive reappraisal is a strategy for emotional regulation, important in the context of anxiety disorders. It is not known whether anxiolytic effects of benzodiazepines affect cognitive reappraisal.<h4>Aims</h4>We aimed to investigate the effect of 25 mg...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0249065 |
| _version_ | 1819012339144327168 |
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| author | Gustav Nilsonne Sandra Tamm Armita Golkar Andreas Olsson Karolina Sörman Katarina Howner Marianne Kristiansson Martin Ingvar Predrag Petrovic |
| author_facet | Gustav Nilsonne Sandra Tamm Armita Golkar Andreas Olsson Karolina Sörman Katarina Howner Marianne Kristiansson Martin Ingvar Predrag Petrovic |
| author_sort | Gustav Nilsonne |
| collection | DOAJ |
| description | <h4>Background</h4>Cognitive reappraisal is a strategy for emotional regulation, important in the context of anxiety disorders. It is not known whether anxiolytic effects of benzodiazepines affect cognitive reappraisal.<h4>Aims</h4>We aimed to investigate the effect of 25 mg oxazepam on cognitive reappraisal.<h4>Methods</h4>In a preliminary investigation, 33 healthy male volunteers were randomised to oxazepam or placebo, and then underwent an experiment where they were asked to use cognitive reappraisal to upregulate or downregulate their emotional response to images with negative or neutral emotional valence. We recorded unpleasantness ratings, skin conductance, superciliary corrugator muscle activity, and heart rate. Participants completed rating scales measuring empathy (Interpersonal Reactivity Index, IRI), anxiety (State-Trait Anxiety Inventory, STAI), alexithymia (Toronto Alexithymia Scale-20, TAS-20), and psychopathy (Psychopathy Personality Inventory-Revised, PPI-R).<h4>Results</h4>Upregulation to negative-valence images in the cognitive reappraisal task caused increased unpleasantness ratings, corrugator activity, and heart rate compared to downregulation. Upregulation to both negative- and neutral-valence images caused increased skin conductance responses. Oxazepam caused lower unpleasantness ratings to negative-valence stimuli, but did not interact with reappraisal instruction on any outcome. Self-rated trait empathy was associated with stronger responses to negative-valence stimuli, whereas self-rated psychopathic traits were associated with weaker responses to negative-valence stimuli.<h4>Conclusions</h4>While 25 mg oxazepam caused lower unpleasantness ratings in response to negative-valence images, we did not observe an effect of 25 mg oxazepam on cognitive reappraisal. |
| first_indexed | 2024-12-21T01:42:29Z |
| format | Article |
| id | doaj.art-9bd159cd0d4748a1bb4420beccf44ef6 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T01:42:29Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9bd159cd0d4748a1bb4420beccf44ef62022-12-21T19:20:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01164e024906510.1371/journal.pone.0249065Oxazepam and cognitive reappraisal: A randomised experiment.Gustav NilsonneSandra TammArmita GolkarAndreas OlssonKarolina SörmanKatarina HownerMarianne KristianssonMartin IngvarPredrag Petrovic<h4>Background</h4>Cognitive reappraisal is a strategy for emotional regulation, important in the context of anxiety disorders. It is not known whether anxiolytic effects of benzodiazepines affect cognitive reappraisal.<h4>Aims</h4>We aimed to investigate the effect of 25 mg oxazepam on cognitive reappraisal.<h4>Methods</h4>In a preliminary investigation, 33 healthy male volunteers were randomised to oxazepam or placebo, and then underwent an experiment where they were asked to use cognitive reappraisal to upregulate or downregulate their emotional response to images with negative or neutral emotional valence. We recorded unpleasantness ratings, skin conductance, superciliary corrugator muscle activity, and heart rate. Participants completed rating scales measuring empathy (Interpersonal Reactivity Index, IRI), anxiety (State-Trait Anxiety Inventory, STAI), alexithymia (Toronto Alexithymia Scale-20, TAS-20), and psychopathy (Psychopathy Personality Inventory-Revised, PPI-R).<h4>Results</h4>Upregulation to negative-valence images in the cognitive reappraisal task caused increased unpleasantness ratings, corrugator activity, and heart rate compared to downregulation. Upregulation to both negative- and neutral-valence images caused increased skin conductance responses. Oxazepam caused lower unpleasantness ratings to negative-valence stimuli, but did not interact with reappraisal instruction on any outcome. Self-rated trait empathy was associated with stronger responses to negative-valence stimuli, whereas self-rated psychopathic traits were associated with weaker responses to negative-valence stimuli.<h4>Conclusions</h4>While 25 mg oxazepam caused lower unpleasantness ratings in response to negative-valence images, we did not observe an effect of 25 mg oxazepam on cognitive reappraisal.https://doi.org/10.1371/journal.pone.0249065 |
| spellingShingle | Gustav Nilsonne Sandra Tamm Armita Golkar Andreas Olsson Karolina Sörman Katarina Howner Marianne Kristiansson Martin Ingvar Predrag Petrovic Oxazepam and cognitive reappraisal: A randomised experiment. PLoS ONE |
| title | Oxazepam and cognitive reappraisal: A randomised experiment. |
| title_full | Oxazepam and cognitive reappraisal: A randomised experiment. |
| title_fullStr | Oxazepam and cognitive reappraisal: A randomised experiment. |
| title_full_unstemmed | Oxazepam and cognitive reappraisal: A randomised experiment. |
| title_short | Oxazepam and cognitive reappraisal: A randomised experiment. |
| title_sort | oxazepam and cognitive reappraisal a randomised experiment |
| url | https://doi.org/10.1371/journal.pone.0249065 |
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