Neuronopathic Gaucher disease models reveal defects in cell growth promoted by Hippo pathway activation

Neuronopathic Gaucher disease models reveal defects in cell growth promoted by Hippo pathway activation

Abstract Gaucher Disease (GD), the most common lysosomal disorder, arises from mutations in the GBA1 gene and is characterized by a wide spectrum of phenotypes, ranging from mild hematological and visceral involvement to severe neurological disease. Neuronopathic patients display dramatic neuronal l...

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Bibliographic Details
Main Authors: Daria Messelodi, Silvia Strocchi, Salvatore Nicola Bertuccio, Pascale Baden, Valentina Indio, Federico M. Giorgi, Alberto Taddia, Salvatore Serravalle, Sabrina Valente, Alessio di Fonzo, Emanuele Frattini, Roberto Bernardoni, Annalisa Pession, Daniela Grifoni, Michela Deleidi, Annalisa Astolfi, Andrea Pession
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-023-04813-2

Internet

https://doi.org/10.1038/s42003-023-04813-2

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