Advances in the pathophysiology of adult-onset focal dystonias: recent neurophysiological and neuroimaging evidence [version 1; peer review: 2 approved]
Focal dystonia is a movement disorder characterized by involuntary muscle contractions that determine abnormal postures. The traditional hypothesis that the pathophysiology of focal dystonia entails a single structural dysfunction (i.e. basal ganglia) has recently come under scrutiny. The proposed n...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2020-01-01
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| Series: | F1000Research |
| Online Access: | https://f1000research.com/articles/9-67/v1 |
| _version_ | 1811336898519498752 |
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| author | Antonella Conte Giovanni Defazio Marcello Mascia Daniele Belvisi Patrizia Pantano Alfredo Berardelli |
| author_facet | Antonella Conte Giovanni Defazio Marcello Mascia Daniele Belvisi Patrizia Pantano Alfredo Berardelli |
| author_sort | Antonella Conte |
| collection | DOAJ |
| description | Focal dystonia is a movement disorder characterized by involuntary muscle contractions that determine abnormal postures. The traditional hypothesis that the pathophysiology of focal dystonia entails a single structural dysfunction (i.e. basal ganglia) has recently come under scrutiny. The proposed network disorder model implies that focal dystonias arise from aberrant communication between various brain areas. Based on findings from animal studies, the role of the cerebellum has attracted increased interest in the last few years. Moreover, it has been increasingly reported that focal dystonias also include nonmotor disturbances, including sensory processing abnormalities, which have begun to attract attention. Current evidence from neurophysiological and neuroimaging investigations suggests that cerebellar involvement in the network and mechanisms underlying sensory abnormalities may have a role in determining the clinical heterogeneity of focal dystonias. |
| first_indexed | 2024-04-13T17:47:07Z |
| format | Article |
| id | doaj.art-9bd37222c8bd4895abc0f5e5ae6ad9b4 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-04-13T17:47:07Z |
| publishDate | 2020-01-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-9bd37222c8bd4895abc0f5e5ae6ad9b42022-12-22T02:36:56ZengF1000 Research LtdF1000Research2046-14022020-01-01910.12688/f1000research.21029.123141Advances in the pathophysiology of adult-onset focal dystonias: recent neurophysiological and neuroimaging evidence [version 1; peer review: 2 approved]Antonella Conte0Giovanni Defazio1Marcello Mascia2Daniele Belvisi3Patrizia Pantano4Alfredo Berardelli5Department of Human Neurosciences, Sapienza, University of Rome, Rome, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, "Aldo Moro", University of Bari, Bari, ItalyDepartment of Basic Medical Sciences, Neuroscience and Sense Organs, "Aldo Moro", University of Bari, Bari, ItalyIRCCS Neuromed, Pozzilli (IS), ItalyDepartment of Human Neurosciences, Sapienza, University of Rome, Rome, ItalyDepartment of Human Neurosciences, Sapienza, University of Rome, Rome, ItalyFocal dystonia is a movement disorder characterized by involuntary muscle contractions that determine abnormal postures. The traditional hypothesis that the pathophysiology of focal dystonia entails a single structural dysfunction (i.e. basal ganglia) has recently come under scrutiny. The proposed network disorder model implies that focal dystonias arise from aberrant communication between various brain areas. Based on findings from animal studies, the role of the cerebellum has attracted increased interest in the last few years. Moreover, it has been increasingly reported that focal dystonias also include nonmotor disturbances, including sensory processing abnormalities, which have begun to attract attention. Current evidence from neurophysiological and neuroimaging investigations suggests that cerebellar involvement in the network and mechanisms underlying sensory abnormalities may have a role in determining the clinical heterogeneity of focal dystonias.https://f1000research.com/articles/9-67/v1 |
| spellingShingle | Antonella Conte Giovanni Defazio Marcello Mascia Daniele Belvisi Patrizia Pantano Alfredo Berardelli Advances in the pathophysiology of adult-onset focal dystonias: recent neurophysiological and neuroimaging evidence [version 1; peer review: 2 approved] F1000Research |
| title | Advances in the pathophysiology of adult-onset focal dystonias: recent neurophysiological and neuroimaging evidence [version 1; peer review: 2 approved] |
| title_full | Advances in the pathophysiology of adult-onset focal dystonias: recent neurophysiological and neuroimaging evidence [version 1; peer review: 2 approved] |
| title_fullStr | Advances in the pathophysiology of adult-onset focal dystonias: recent neurophysiological and neuroimaging evidence [version 1; peer review: 2 approved] |
| title_full_unstemmed | Advances in the pathophysiology of adult-onset focal dystonias: recent neurophysiological and neuroimaging evidence [version 1; peer review: 2 approved] |
| title_short | Advances in the pathophysiology of adult-onset focal dystonias: recent neurophysiological and neuroimaging evidence [version 1; peer review: 2 approved] |
| title_sort | advances in the pathophysiology of adult onset focal dystonias recent neurophysiological and neuroimaging evidence version 1 peer review 2 approved |
| url | https://f1000research.com/articles/9-67/v1 |
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