A nomogram for predicting upper urinary tract damage risk in children with neurogenic bladder
PurposeTo establish a predictive model for upper urinary tract damage (UUTD) in children with neurogenic bladder (NB) and verify its efficacy.MethodsA retrospective study was conducted that consisted of a training cohort with 167 NB patients and a validation cohort with 100 NB children. The clinical...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-12-01
|
| Series: | Frontiers in Pediatrics |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2022.1050013/full |
| _version_ | 1811178465149321216 |
|---|---|
| author | Qi Li Qi Li Miao Cai Miao Cai Qingsong Pu Shengde Wu Shengde Wu Xing Liu Xing Liu Tao Lin Tao Lin Dawei He Dawei He Jianguo Wen Guanghui Wei Guanghui Wei |
| author_facet | Qi Li Qi Li Miao Cai Miao Cai Qingsong Pu Shengde Wu Shengde Wu Xing Liu Xing Liu Tao Lin Tao Lin Dawei He Dawei He Jianguo Wen Guanghui Wei Guanghui Wei |
| author_sort | Qi Li |
| collection | DOAJ |
| description | PurposeTo establish a predictive model for upper urinary tract damage (UUTD) in children with neurogenic bladder (NB) and verify its efficacy.MethodsA retrospective study was conducted that consisted of a training cohort with 167 NB patients and a validation cohort with 100 NB children. The clinical data of the two groups were compared first, and then univariate and multivariate logistic regression analyses were performed on the training cohort to identify predictors and develop the nomogram. The accuracy and clinical usefulness of the nomogram were verified by receiver operating characteristic (ROC) curve, calibration curve and decision curve analyses.ResultsThere were no significant differences in other parameters between the training and validation cohorts except for age (all P > 0.05). Recurrent urinary tract infection, bladder compliance, detrusor leak point pressure, overactive bladder and clean intermittent catheterization were identified as predictors and assembled into the nomogram. The nomogram showed good discrimination with the area under the ROC curve (AUC) in the training cohort (0.806, 95% CI: 0.737–0.874) and validation cohort (0.831, 95% CI: 0.753–0.0.909). The calibration curve showed that the nomograms were well calibrated, with no significant difference between the predicted and observed probabilities. Decision curve analysis indicated that the nomogram has good clinical applicability.ConclusionThis study presents an effective nomogram incorporating five clinical characteristics that can be conveniently applied to assess NB children' risk of progressing to UUTD. |
| first_indexed | 2024-04-11T06:19:53Z |
| format | Article |
| id | doaj.art-9bd3e2375a3140d48ca3d3d8784ae15e |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-11T06:19:53Z |
| publishDate | 2022-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-9bd3e2375a3140d48ca3d3d8784ae15e2022-12-22T04:40:51ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602022-12-011010.3389/fped.2022.10500131050013A nomogram for predicting upper urinary tract damage risk in children with neurogenic bladderQi Li0Qi Li1Miao Cai2Miao Cai3Qingsong Pu4Shengde Wu5Shengde Wu6Xing Liu7Xing Liu8Tao Lin9Tao Lin10Dawei He11Dawei He12Jianguo Wen13Guanghui Wei14Guanghui Wei15Department of Urology, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, ChinaDepartment of Urology, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, ChinaHenan Joint International Pediatric Urodynamic Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Urology, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, ChinaDepartment of Urology, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, ChinaDepartment of Urology, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, ChinaDepartment of Urology, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, ChinaHenan Joint International Pediatric Urodynamic Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Urology, Children's Hospital of Chongqing Medical University, Chongqing, ChinaChongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, ChinaPurposeTo establish a predictive model for upper urinary tract damage (UUTD) in children with neurogenic bladder (NB) and verify its efficacy.MethodsA retrospective study was conducted that consisted of a training cohort with 167 NB patients and a validation cohort with 100 NB children. The clinical data of the two groups were compared first, and then univariate and multivariate logistic regression analyses were performed on the training cohort to identify predictors and develop the nomogram. The accuracy and clinical usefulness of the nomogram were verified by receiver operating characteristic (ROC) curve, calibration curve and decision curve analyses.ResultsThere were no significant differences in other parameters between the training and validation cohorts except for age (all P > 0.05). Recurrent urinary tract infection, bladder compliance, detrusor leak point pressure, overactive bladder and clean intermittent catheterization were identified as predictors and assembled into the nomogram. The nomogram showed good discrimination with the area under the ROC curve (AUC) in the training cohort (0.806, 95% CI: 0.737–0.874) and validation cohort (0.831, 95% CI: 0.753–0.0.909). The calibration curve showed that the nomograms were well calibrated, with no significant difference between the predicted and observed probabilities. Decision curve analysis indicated that the nomogram has good clinical applicability.ConclusionThis study presents an effective nomogram incorporating five clinical characteristics that can be conveniently applied to assess NB children' risk of progressing to UUTD.https://www.frontiersin.org/articles/10.3389/fped.2022.1050013/fullchildneurogenic bladderupper urinary tract damagenomogramlogistic regression |
| spellingShingle | Qi Li Qi Li Miao Cai Miao Cai Qingsong Pu Shengde Wu Shengde Wu Xing Liu Xing Liu Tao Lin Tao Lin Dawei He Dawei He Jianguo Wen Guanghui Wei Guanghui Wei A nomogram for predicting upper urinary tract damage risk in children with neurogenic bladder Frontiers in Pediatrics child neurogenic bladder upper urinary tract damage nomogram logistic regression |
| title | A nomogram for predicting upper urinary tract damage risk in children with neurogenic bladder |
| title_full | A nomogram for predicting upper urinary tract damage risk in children with neurogenic bladder |
| title_fullStr | A nomogram for predicting upper urinary tract damage risk in children with neurogenic bladder |
| title_full_unstemmed | A nomogram for predicting upper urinary tract damage risk in children with neurogenic bladder |
| title_short | A nomogram for predicting upper urinary tract damage risk in children with neurogenic bladder |
| title_sort | nomogram for predicting upper urinary tract damage risk in children with neurogenic bladder |
| topic | child neurogenic bladder upper urinary tract damage nomogram logistic regression |
| url | https://www.frontiersin.org/articles/10.3389/fped.2022.1050013/full |
| work_keys_str_mv | AT qili anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT qili anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT miaocai anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT miaocai anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT qingsongpu anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT shengdewu anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT shengdewu anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT xingliu anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT xingliu anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT taolin anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT taolin anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT daweihe anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT daweihe anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT jianguowen anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT guanghuiwei anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT guanghuiwei anomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT qili nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT qili nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT miaocai nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT miaocai nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT qingsongpu nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT shengdewu nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT shengdewu nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT xingliu nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT xingliu nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT taolin nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT taolin nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT daweihe nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT daweihe nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT jianguowen nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT guanghuiwei nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder AT guanghuiwei nomogramforpredictingupperurinarytractdamageriskinchildrenwithneurogenicbladder |