Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges
Chitin is the second most abundant biopolymer consisting of <i>N</i>-acetylglucosamine units and is primarily derived from the shells of marine crustaceans and the cell walls of organisms (such as bacteria, fungi, and algae). Being a biopolymer, its materialistic properties, such as biod...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/21/4/211 |
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| author | Bhuvi Sachdeva Punya Sachdeva Arvind Negi Shampa Ghosh Sungsoo Han Saikat Dewanjee Saurabh Kumar Jha Rakesh Bhaskar Jitendra Kumar Sinha Ana Cláudia Paiva-Santos Niraj Kumar Jha Kavindra Kumar Kesari |
| author_facet | Bhuvi Sachdeva Punya Sachdeva Arvind Negi Shampa Ghosh Sungsoo Han Saikat Dewanjee Saurabh Kumar Jha Rakesh Bhaskar Jitendra Kumar Sinha Ana Cláudia Paiva-Santos Niraj Kumar Jha Kavindra Kumar Kesari |
| author_sort | Bhuvi Sachdeva |
| collection | DOAJ |
| description | Chitin is the second most abundant biopolymer consisting of <i>N</i>-acetylglucosamine units and is primarily derived from the shells of marine crustaceans and the cell walls of organisms (such as bacteria, fungi, and algae). Being a biopolymer, its materialistic properties, such as biodegradability, and biocompatibility, make it a suitable choice for biomedical applications. Similarly, its deacetylated derivative, chitosan, exhibits similar biocompatibility and biodegradability properties, making it a suitable support material for biomedical applications. Furthermore, it has intrinsic material properties such as antioxidant, antibacterial, and antitumor. Population studies have projected nearly 12 million cancer patients across the globe, where most will be suffering from solid tumors. One of the shortcomings of potent anticancer drugs is finding a suitable cellular delivery material or system. Therefore, identifying new drug carriers to achieve effective anticancer therapy is becoming essential. This paper focuses on the strategies implemented using chitin and chitosan biopolymers in drug delivery for cancer treatment. |
| first_indexed | 2024-03-11T04:49:16Z |
| format | Article |
| id | doaj.art-9bd4a01f4298439686effdd952a1b9c2 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-11T04:49:16Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-9bd4a01f4298439686effdd952a1b9c22023-11-17T20:10:03ZengMDPI AGMarine Drugs1660-33972023-03-0121421110.3390/md21040211Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and ChallengesBhuvi Sachdeva0Punya Sachdeva1Arvind Negi2Shampa Ghosh3Sungsoo Han4Saikat Dewanjee5Saurabh Kumar Jha6Rakesh Bhaskar7Jitendra Kumar Sinha8Ana Cláudia Paiva-Santos9Niraj Kumar Jha10Kavindra Kumar Kesari11Department of Physics and Astrophysics, Bhagini Nivedita College, University of Delhi, Delhi 110072, IndiaGloNeuro, Sector 107, Vishwakarma Road, Noida 201301, IndiaDepartment of Bioproducts and Biosystems, School of Chemical Engineering, Aalto University, 00076 Espoo, FinlandGloNeuro, Sector 107, Vishwakarma Road, Noida 201301, IndiaSchool of Chemical Engineering, Yeungnam University, Gyeonsang 38541, Republic of KoreaAdvanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, IndiaDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201310, IndiaSchool of Chemical Engineering, Yeungnam University, Gyeonsang 38541, Republic of KoreaGloNeuro, Sector 107, Vishwakarma Road, Noida 201301, IndiaDepartment of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, PortugalDepartment of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201310, IndiaDepartment of Applied Physics, School of Science, Aalto University, 00076 Espoo, FinlandChitin is the second most abundant biopolymer consisting of <i>N</i>-acetylglucosamine units and is primarily derived from the shells of marine crustaceans and the cell walls of organisms (such as bacteria, fungi, and algae). Being a biopolymer, its materialistic properties, such as biodegradability, and biocompatibility, make it a suitable choice for biomedical applications. Similarly, its deacetylated derivative, chitosan, exhibits similar biocompatibility and biodegradability properties, making it a suitable support material for biomedical applications. Furthermore, it has intrinsic material properties such as antioxidant, antibacterial, and antitumor. Population studies have projected nearly 12 million cancer patients across the globe, where most will be suffering from solid tumors. One of the shortcomings of potent anticancer drugs is finding a suitable cellular delivery material or system. Therefore, identifying new drug carriers to achieve effective anticancer therapy is becoming essential. This paper focuses on the strategies implemented using chitin and chitosan biopolymers in drug delivery for cancer treatment.https://www.mdpi.com/1660-3397/21/4/211nanoparticleschitosanchitinpolysaccharidesnanocarriersanticancer agents |
| spellingShingle | Bhuvi Sachdeva Punya Sachdeva Arvind Negi Shampa Ghosh Sungsoo Han Saikat Dewanjee Saurabh Kumar Jha Rakesh Bhaskar Jitendra Kumar Sinha Ana Cláudia Paiva-Santos Niraj Kumar Jha Kavindra Kumar Kesari Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges Marine Drugs nanoparticles chitosan chitin polysaccharides nanocarriers anticancer agents |
| title | Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges |
| title_full | Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges |
| title_fullStr | Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges |
| title_full_unstemmed | Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges |
| title_short | Chitosan Nanoparticles-Based Cancer Drug Delivery: Application and Challenges |
| title_sort | chitosan nanoparticles based cancer drug delivery application and challenges |
| topic | nanoparticles chitosan chitin polysaccharides nanocarriers anticancer agents |
| url | https://www.mdpi.com/1660-3397/21/4/211 |
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