Small Nucleolar Derived RNAs as Regulators of Human Cancer
In the past decade, RNA fragments derived from full-length small nucleolar RNAs (snoRNAs) have been shown to be specifically excised and functional. These sno-derived RNAs (sdRNAs) have been implicated as gene regulators in a multitude of cancers, controlling a variety of genes post-transcriptionall...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/8/1819 |
| _version_ | 1797411108286365696 |
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| author | Alexander Bishop Coley Jeffrey David DeMeis Neil Yash Chaudhary Glen Mark Borchert |
| author_facet | Alexander Bishop Coley Jeffrey David DeMeis Neil Yash Chaudhary Glen Mark Borchert |
| author_sort | Alexander Bishop Coley |
| collection | DOAJ |
| description | In the past decade, RNA fragments derived from full-length small nucleolar RNAs (snoRNAs) have been shown to be specifically excised and functional. These sno-derived RNAs (sdRNAs) have been implicated as gene regulators in a multitude of cancers, controlling a variety of genes post-transcriptionally via association with the RNA-induced silencing complex (RISC). In this review, we have summarized the literature connecting sdRNAs to cancer gene regulation. SdRNAs possess miRNA-like functions and are able to fill the role of tumor-suppressing or tumor-promoting RNAs in a tissue context-dependent manner. Indeed, there are many miRNAs that are actually derived from snoRNA transcripts, meaning that they are truly sdRNAs and as such are included in this review. As sdRNAs are frequently discarded from ncRNA analyses, we emphasize that sdRNAs are functionally relevant gene regulators and likely represent an overlooked subclass of miRNAs. Based on the evidence provided by the papers reviewed here, we propose that sdRNAs deserve more extensive study to better understand their underlying biology and to identify previously overlooked biomarkers and therapeutic targets for a multitude of human cancers. |
| first_indexed | 2024-03-09T04:41:11Z |
| format | Article |
| id | doaj.art-9bd51eb841294aa888b80bf53547d5b3 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T04:41:11Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-9bd51eb841294aa888b80bf53547d5b32023-12-03T13:21:27ZengMDPI AGBiomedicines2227-90592022-07-01108181910.3390/biomedicines10081819Small Nucleolar Derived RNAs as Regulators of Human CancerAlexander Bishop Coley0Jeffrey David DeMeis1Neil Yash Chaudhary2Glen Mark Borchert3Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL 36688, USADepartment of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL 36688, USADepartment of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL 36688, USADepartment of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL 36688, USAIn the past decade, RNA fragments derived from full-length small nucleolar RNAs (snoRNAs) have been shown to be specifically excised and functional. These sno-derived RNAs (sdRNAs) have been implicated as gene regulators in a multitude of cancers, controlling a variety of genes post-transcriptionally via association with the RNA-induced silencing complex (RISC). In this review, we have summarized the literature connecting sdRNAs to cancer gene regulation. SdRNAs possess miRNA-like functions and are able to fill the role of tumor-suppressing or tumor-promoting RNAs in a tissue context-dependent manner. Indeed, there are many miRNAs that are actually derived from snoRNA transcripts, meaning that they are truly sdRNAs and as such are included in this review. As sdRNAs are frequently discarded from ncRNA analyses, we emphasize that sdRNAs are functionally relevant gene regulators and likely represent an overlooked subclass of miRNAs. Based on the evidence provided by the papers reviewed here, we propose that sdRNAs deserve more extensive study to better understand their underlying biology and to identify previously overlooked biomarkers and therapeutic targets for a multitude of human cancers.https://www.mdpi.com/2227-9059/10/8/1819cancergene regulationsmall nucleolar RNA (snoRNA)small nucleolar derived RNA (sdRNA)microRNA (miRNA)RNA |
| spellingShingle | Alexander Bishop Coley Jeffrey David DeMeis Neil Yash Chaudhary Glen Mark Borchert Small Nucleolar Derived RNAs as Regulators of Human Cancer Biomedicines cancer gene regulation small nucleolar RNA (snoRNA) small nucleolar derived RNA (sdRNA) microRNA (miRNA) RNA |
| title | Small Nucleolar Derived RNAs as Regulators of Human Cancer |
| title_full | Small Nucleolar Derived RNAs as Regulators of Human Cancer |
| title_fullStr | Small Nucleolar Derived RNAs as Regulators of Human Cancer |
| title_full_unstemmed | Small Nucleolar Derived RNAs as Regulators of Human Cancer |
| title_short | Small Nucleolar Derived RNAs as Regulators of Human Cancer |
| title_sort | small nucleolar derived rnas as regulators of human cancer |
| topic | cancer gene regulation small nucleolar RNA (snoRNA) small nucleolar derived RNA (sdRNA) microRNA (miRNA) RNA |
| url | https://www.mdpi.com/2227-9059/10/8/1819 |
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