Development and validation of the patient-reported outcome for older people living with HIV/AIDS in China (PROHIV-OLD)
Abstract Background The involvement of quality of life as the UNAIDS fourth 90 target to monitor the global HIV response highlighted the development of patient-reported outcome (PRO) measures to help address the holistic needs of people living with HIV/AIDS (PLWHA) beyond viral suppression. This stu...
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| Format: | Article |
| Language: | English |
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BMC
2024-04-01
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| Series: | Health and Quality of Life Outcomes |
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| Online Access: | https://doi.org/10.1186/s12955-024-02243-0 |
| _version_ | 1827291340881264640 |
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| author | Rui Zhou Ying-Jing Zheng Bei-Jia Wang Donald L. Patrick Todd C. Edwards Jing-Yi Yun Jie Zhou Ren-Jun Gu Bing-Hui Miao Hong-Mei Wang |
| author_facet | Rui Zhou Ying-Jing Zheng Bei-Jia Wang Donald L. Patrick Todd C. Edwards Jing-Yi Yun Jie Zhou Ren-Jun Gu Bing-Hui Miao Hong-Mei Wang |
| author_sort | Rui Zhou |
| collection | DOAJ |
| description | Abstract Background The involvement of quality of life as the UNAIDS fourth 90 target to monitor the global HIV response highlighted the development of patient-reported outcome (PRO) measures to help address the holistic needs of people living with HIV/AIDS (PLWHA) beyond viral suppression. This study developed and tested preliminary measurement properties of a new patient-reported outcome (PROHIV-OLD) measure designed specifically to capture influences of HIV on patients aged 50 and older in China. Methods Ninety-three older people living with HIV/AIDS (PLWHA) were interviewed to solicit items and two rounds of patient cognitive interviews were conducted to modify the content and wording of the initial items. A validation study was then conducted to refine the initial instrument and evaluate measurement properties. Patients were recruited between February 2021 and November 2021, and followed six months later after the first investigation. Classical test theory (CTT) and item response theory (IRT) were used to select items using the baseline data. The follow-up data were used to evaluate the measurement properties of the final instrument. Results A total of 600 patients were recruited at the baseline. Of the 485 patients who completed the follow-up investigation, 483 were included in the validation sample. The final scale of PROHIV-OLD contained 25 items describing five dimensions (physical symptoms, mental status, illness perception, family relationship, and treatment). All the PROHIV-OLD dimensions had satisfactory reliability with Cronbach’s alpha coefficient, McDonald’s ω, and composite reliability of each dimension being all higher than 0.85. Most dimensions met the test-retest reliability standard except for the physical symptoms dimension (ICC = 0.64). Confirmatory factor analysis supported the structural validity of the final scale, and the model fit index satisfied the criterion. The correlations between dimensions of PROHIV-OLD and MOS-HIV met hypotheses in general. Significant differences on scores of the PROHIV-OLD were found between demographic and clinical subgroups, supporting known-groups validity. Conclusions The PROHIV-OLD was found to have good feasibility, reliability and validity for evaluating health outcome of Chinese older PLWHA. Other measurement properties such as responsiveness and interpretability will be further examined. |
| first_indexed | 2024-04-24T12:35:19Z |
| format | Article |
| id | doaj.art-9bd5f554110e40bd801e783185e8de9d |
| institution | Directory Open Access Journal |
| issn | 1477-7525 |
| language | English |
| last_indexed | 2024-04-24T12:35:19Z |
| publishDate | 2024-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Health and Quality of Life Outcomes |
| spelling | doaj.art-9bd5f554110e40bd801e783185e8de9d2024-04-07T11:31:43ZengBMCHealth and Quality of Life Outcomes1477-75252024-04-0122111410.1186/s12955-024-02243-0Development and validation of the patient-reported outcome for older people living with HIV/AIDS in China (PROHIV-OLD)Rui Zhou0Ying-Jing Zheng1Bei-Jia Wang2Donald L. Patrick3Todd C. Edwards4Jing-Yi Yun5Jie Zhou6Ren-Jun Gu7Bing-Hui Miao8Hong-Mei Wang9Department of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Health Systems and Population Health, University of WashingtonDepartment of Health Systems and Population Health, University of WashingtonDepartment of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of MedicineDepartment of Social Medicine of School of Public Health and Department of Pharmacy of the First Affiliated Hospital, Zhejiang University School of MedicineAbstract Background The involvement of quality of life as the UNAIDS fourth 90 target to monitor the global HIV response highlighted the development of patient-reported outcome (PRO) measures to help address the holistic needs of people living with HIV/AIDS (PLWHA) beyond viral suppression. This study developed and tested preliminary measurement properties of a new patient-reported outcome (PROHIV-OLD) measure designed specifically to capture influences of HIV on patients aged 50 and older in China. Methods Ninety-three older people living with HIV/AIDS (PLWHA) were interviewed to solicit items and two rounds of patient cognitive interviews were conducted to modify the content and wording of the initial items. A validation study was then conducted to refine the initial instrument and evaluate measurement properties. Patients were recruited between February 2021 and November 2021, and followed six months later after the first investigation. Classical test theory (CTT) and item response theory (IRT) were used to select items using the baseline data. The follow-up data were used to evaluate the measurement properties of the final instrument. Results A total of 600 patients were recruited at the baseline. Of the 485 patients who completed the follow-up investigation, 483 were included in the validation sample. The final scale of PROHIV-OLD contained 25 items describing five dimensions (physical symptoms, mental status, illness perception, family relationship, and treatment). All the PROHIV-OLD dimensions had satisfactory reliability with Cronbach’s alpha coefficient, McDonald’s ω, and composite reliability of each dimension being all higher than 0.85. Most dimensions met the test-retest reliability standard except for the physical symptoms dimension (ICC = 0.64). Confirmatory factor analysis supported the structural validity of the final scale, and the model fit index satisfied the criterion. The correlations between dimensions of PROHIV-OLD and MOS-HIV met hypotheses in general. Significant differences on scores of the PROHIV-OLD were found between demographic and clinical subgroups, supporting known-groups validity. Conclusions The PROHIV-OLD was found to have good feasibility, reliability and validity for evaluating health outcome of Chinese older PLWHA. Other measurement properties such as responsiveness and interpretability will be further examined.https://doi.org/10.1186/s12955-024-02243-0HIV/AIDSPatient-reported outcomeItem response theoryClassical test theoryReliabilityValidity |
| spellingShingle | Rui Zhou Ying-Jing Zheng Bei-Jia Wang Donald L. Patrick Todd C. Edwards Jing-Yi Yun Jie Zhou Ren-Jun Gu Bing-Hui Miao Hong-Mei Wang Development and validation of the patient-reported outcome for older people living with HIV/AIDS in China (PROHIV-OLD) Health and Quality of Life Outcomes HIV/AIDS Patient-reported outcome Item response theory Classical test theory Reliability Validity |
| title | Development and validation of the patient-reported outcome for older people living with HIV/AIDS in China (PROHIV-OLD) |
| title_full | Development and validation of the patient-reported outcome for older people living with HIV/AIDS in China (PROHIV-OLD) |
| title_fullStr | Development and validation of the patient-reported outcome for older people living with HIV/AIDS in China (PROHIV-OLD) |
| title_full_unstemmed | Development and validation of the patient-reported outcome for older people living with HIV/AIDS in China (PROHIV-OLD) |
| title_short | Development and validation of the patient-reported outcome for older people living with HIV/AIDS in China (PROHIV-OLD) |
| title_sort | development and validation of the patient reported outcome for older people living with hiv aids in china prohiv old |
| topic | HIV/AIDS Patient-reported outcome Item response theory Classical test theory Reliability Validity |
| url | https://doi.org/10.1186/s12955-024-02243-0 |
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