Skeletal muscle atrophy, regeneration, and dysfunction in heart failure: Impact of exercise training
This review highlights some established and some more contemporary mechanisms responsible for heart failure (HF)-induced skeletal muscle wasting and weakness. We first describe the effects of HF on the relationship between protein synthesis and degradation rates, which determine muscle mass, the inv...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | Journal of Sport and Health Science |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2095254623000406 |
| _version_ | 1797739010237399040 |
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| author | Harrison Gallagher Paul W. Hendrickse Marcelo G. Pereira T. Scott Bowen |
| author_facet | Harrison Gallagher Paul W. Hendrickse Marcelo G. Pereira T. Scott Bowen |
| author_sort | Harrison Gallagher |
| collection | DOAJ |
| description | This review highlights some established and some more contemporary mechanisms responsible for heart failure (HF)-induced skeletal muscle wasting and weakness. We first describe the effects of HF on the relationship between protein synthesis and degradation rates, which determine muscle mass, the involvement of the satellite cells for continual muscle regeneration, and changes in myofiber calcium homeostasis linked to contractile dysfunction. We then highlight key mechanistic effects of both aerobic and resistance exercise training on skeletal muscle in HF and outline its application as a beneficial treatment. Overall, HF causes multiple impairments related to autophagy, anabolic-catabolic signaling, satellite cell proliferation, and calcium homeostasis, which together promote fiber atrophy, contractile dysfunction, and impaired regeneration. Although both wasting and weakness are partly rescued by aerobic and resistance exercise training in HF, the effects of satellite cell dynamics remain poorly explored. |
| first_indexed | 2024-03-12T13:51:11Z |
| format | Article |
| id | doaj.art-9bd6eecc23064fb28ccb3a64d0f67f76 |
| institution | Directory Open Access Journal |
| issn | 2095-2546 |
| language | English |
| last_indexed | 2024-03-12T13:51:11Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Sport and Health Science |
| spelling | doaj.art-9bd6eecc23064fb28ccb3a64d0f67f762023-08-23T04:32:58ZengElsevierJournal of Sport and Health Science2095-25462023-09-01125557567Skeletal muscle atrophy, regeneration, and dysfunction in heart failure: Impact of exercise trainingHarrison Gallagher0Paul W. Hendrickse1Marcelo G. Pereira2T. Scott Bowen3School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UKSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UKSchool of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UKCorresponding author.; School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UKThis review highlights some established and some more contemporary mechanisms responsible for heart failure (HF)-induced skeletal muscle wasting and weakness. We first describe the effects of HF on the relationship between protein synthesis and degradation rates, which determine muscle mass, the involvement of the satellite cells for continual muscle regeneration, and changes in myofiber calcium homeostasis linked to contractile dysfunction. We then highlight key mechanistic effects of both aerobic and resistance exercise training on skeletal muscle in HF and outline its application as a beneficial treatment. Overall, HF causes multiple impairments related to autophagy, anabolic-catabolic signaling, satellite cell proliferation, and calcium homeostasis, which together promote fiber atrophy, contractile dysfunction, and impaired regeneration. Although both wasting and weakness are partly rescued by aerobic and resistance exercise training in HF, the effects of satellite cell dynamics remain poorly explored.http://www.sciencedirect.com/science/article/pii/S2095254623000406CalciumExercise trainingHeart failureSatellite cellsSkeletal muscle wasting |
| spellingShingle | Harrison Gallagher Paul W. Hendrickse Marcelo G. Pereira T. Scott Bowen Skeletal muscle atrophy, regeneration, and dysfunction in heart failure: Impact of exercise training Journal of Sport and Health Science Calcium Exercise training Heart failure Satellite cells Skeletal muscle wasting |
| title | Skeletal muscle atrophy, regeneration, and dysfunction in heart failure: Impact of exercise training |
| title_full | Skeletal muscle atrophy, regeneration, and dysfunction in heart failure: Impact of exercise training |
| title_fullStr | Skeletal muscle atrophy, regeneration, and dysfunction in heart failure: Impact of exercise training |
| title_full_unstemmed | Skeletal muscle atrophy, regeneration, and dysfunction in heart failure: Impact of exercise training |
| title_short | Skeletal muscle atrophy, regeneration, and dysfunction in heart failure: Impact of exercise training |
| title_sort | skeletal muscle atrophy regeneration and dysfunction in heart failure impact of exercise training |
| topic | Calcium Exercise training Heart failure Satellite cells Skeletal muscle wasting |
| url | http://www.sciencedirect.com/science/article/pii/S2095254623000406 |
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