Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin’s Lymphoma
A wide range of histological as well as clinical properties are exhibited by B-cell non-Hodgkin’s lymphomas. These properties could make the diagnostics process complicated. The diagnosis of lymphomas at an initial stage is essential because early remedial actions taken against destructive subtypes...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/13/5/861 |
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| author | Abdullah Alfaifi Mohammed Y. Refai Mohammed Alsaadi Salem Bahashwan Hafiz Malhan Waiel Al-Kahiry Enas Dammag Ageel Ageel Amjed Mahzary Raed Albiheyri Hussein Almehdar Ishtiaq Qadri |
| author_facet | Abdullah Alfaifi Mohammed Y. Refai Mohammed Alsaadi Salem Bahashwan Hafiz Malhan Waiel Al-Kahiry Enas Dammag Ageel Ageel Amjed Mahzary Raed Albiheyri Hussein Almehdar Ishtiaq Qadri |
| author_sort | Abdullah Alfaifi |
| collection | DOAJ |
| description | A wide range of histological as well as clinical properties are exhibited by B-cell non-Hodgkin’s lymphomas. These properties could make the diagnostics process complicated. The diagnosis of lymphomas at an initial stage is essential because early remedial actions taken against destructive subtypes are commonly deliberated as successful and restorative. Therefore, better protective action is needed to improve the condition of those patients who are extensively affected by cancer when diagnosed for the first time. The development of new and efficient methods for early detection of cancer has become crucial nowadays. Biomarkers are urgently needed for diagnosing B-cell non-Hodgkin’s lymphoma and assessing the severity of the disease and its prognosis. New possibilities are now open for diagnosing cancer with the help of metabolomics. The study of all the metabolites synthesised in the human body is called “metabolomics.” A patient’s phenotype is directly linked with metabolomics, which can help in providing some clinically beneficial biomarkers and is applied in the diagnostics of B-cell non-Hodgkin’s lymphoma. In cancer research, it can analyse the cancerous metabolome to identify the metabolic biomarkers. This review provides an understanding of B-cell non-Hodgkin’s lymphoma metabolism and its applications in medical diagnostics. A description of the workflow based on metabolomics is also provided, along with the benefits and drawbacks of various techniques. The use of predictive metabolic biomarkers for the diagnosis and prognosis of B-cell non-Hodgkin’s lymphoma is also explored. Thus, we can say that abnormalities related to metabolic processes can occur in a vast range of B-cell non-Hodgkin’s lymphomas. The metabolic biomarkers could only be discovered and identified as innovative therapeutic objects if we explored and researched them. In the near future, the innovations involving metabolomics could prove fruitful for predicting outcomes and bringing out novel remedial approaches. |
| first_indexed | 2024-03-11T07:27:48Z |
| format | Article |
| id | doaj.art-9bd7f5cac1ed433abfa2d7822328b534 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-11T07:27:48Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-9bd7f5cac1ed433abfa2d7822328b5342023-11-17T07:29:12ZengMDPI AGDiagnostics2075-44182023-02-0113586110.3390/diagnostics13050861Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin’s LymphomaAbdullah Alfaifi0Mohammed Y. Refai1Mohammed Alsaadi2Salem Bahashwan3Hafiz Malhan4Waiel Al-Kahiry5Enas Dammag6Ageel Ageel7Amjed Mahzary8Raed Albiheyri9Hussein Almehdar10Ishtiaq Qadri11Department of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Biochemistry, College of Science, University of Jeddah, Jeddah 21493, Saudi ArabiaDepartment of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaHematology Research Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi ArabiaPrince Mohammed Bin Nasser Hospital, Ministry of Health, Jazan 82943, Saudi ArabiaPrince Mohammed Bin Nasser Hospital, Ministry of Health, Jazan 82943, Saudi ArabiaPrince Mohammed Bin Nasser Hospital, Ministry of Health, Jazan 82943, Saudi ArabiaPrince Mohammed Bin Nasser Hospital, Ministry of Health, Jazan 82943, Saudi ArabiaEradah Hospital, Ministry of Health, Jazan 82943, Saudi ArabiaDepartment of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Biological Science, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaA wide range of histological as well as clinical properties are exhibited by B-cell non-Hodgkin’s lymphomas. These properties could make the diagnostics process complicated. The diagnosis of lymphomas at an initial stage is essential because early remedial actions taken against destructive subtypes are commonly deliberated as successful and restorative. Therefore, better protective action is needed to improve the condition of those patients who are extensively affected by cancer when diagnosed for the first time. The development of new and efficient methods for early detection of cancer has become crucial nowadays. Biomarkers are urgently needed for diagnosing B-cell non-Hodgkin’s lymphoma and assessing the severity of the disease and its prognosis. New possibilities are now open for diagnosing cancer with the help of metabolomics. The study of all the metabolites synthesised in the human body is called “metabolomics.” A patient’s phenotype is directly linked with metabolomics, which can help in providing some clinically beneficial biomarkers and is applied in the diagnostics of B-cell non-Hodgkin’s lymphoma. In cancer research, it can analyse the cancerous metabolome to identify the metabolic biomarkers. This review provides an understanding of B-cell non-Hodgkin’s lymphoma metabolism and its applications in medical diagnostics. A description of the workflow based on metabolomics is also provided, along with the benefits and drawbacks of various techniques. The use of predictive metabolic biomarkers for the diagnosis and prognosis of B-cell non-Hodgkin’s lymphoma is also explored. Thus, we can say that abnormalities related to metabolic processes can occur in a vast range of B-cell non-Hodgkin’s lymphomas. The metabolic biomarkers could only be discovered and identified as innovative therapeutic objects if we explored and researched them. In the near future, the innovations involving metabolomics could prove fruitful for predicting outcomes and bringing out novel remedial approaches.https://www.mdpi.com/2075-4418/13/5/861metabolomicsB-cell non-Hodgkin’s lymphomabiomarkersmetabolitesearly diagnosistherapeutic |
| spellingShingle | Abdullah Alfaifi Mohammed Y. Refai Mohammed Alsaadi Salem Bahashwan Hafiz Malhan Waiel Al-Kahiry Enas Dammag Ageel Ageel Amjed Mahzary Raed Albiheyri Hussein Almehdar Ishtiaq Qadri Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin’s Lymphoma Diagnostics metabolomics B-cell non-Hodgkin’s lymphoma biomarkers metabolites early diagnosis therapeutic |
| title | Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin’s Lymphoma |
| title_full | Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin’s Lymphoma |
| title_fullStr | Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin’s Lymphoma |
| title_full_unstemmed | Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin’s Lymphoma |
| title_short | Metabolomics: A New Era in the Diagnosis or Prognosis of B-Cell Non-Hodgkin’s Lymphoma |
| title_sort | metabolomics a new era in the diagnosis or prognosis of b cell non hodgkin s lymphoma |
| topic | metabolomics B-cell non-Hodgkin’s lymphoma biomarkers metabolites early diagnosis therapeutic |
| url | https://www.mdpi.com/2075-4418/13/5/861 |
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