Prognostic analysis of lung squamous cell carcinoma patients with second primary malignancies: a SEER database study
BackgroundAs lung squamous cell carcinoma (LUSC) patients are at increased risk of developing a second primary cancer, this complicates the patient’s condition and thus makes prognostic assessment more difficult, posing a significant prognostic challenge for clinicians. Our goal was to assess the pr...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1294383/full |
| _version_ | 1797302424006819840 |
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| author | Weiqing Han Silin Wang Lang Su Jianjun Xu Yiping Wei |
| author_facet | Weiqing Han Silin Wang Lang Su Jianjun Xu Yiping Wei |
| author_sort | Weiqing Han |
| collection | DOAJ |
| description | BackgroundAs lung squamous cell carcinoma (LUSC) patients are at increased risk of developing a second primary cancer, this complicates the patient’s condition and thus makes prognostic assessment more difficult, posing a significant prognostic challenge for clinicians. Our goal was to assess the prognosis of LUSC patients with a second primary tumor, and provide insights into appropriate therapy and monitoring strategies.MethodsData was obtained for LUSC patients from the Surveillance, Epidemiology, and End Results (SEER) database. The LUSC patients were divided into three groups (LS-SPM, OT-LUSC and LUSC-only). Univariate and stratified analyses were performed for the baseline and clinical characteristics of the participants. Multiple regression and Kaplan-Meier survival analyses were also performed, followed by a final life table analysis.ResultsIn our sample of 101,626 patients, the HR for OS in the LS-SPM group was 0.40 in univariate analysis. Kaplan-Meier survival curves showed that LS-SPM patients had considerably longer lifespans compared to the other groups. The LS-SPM patients had median and mean survival times of 64 months and 89.11 months. Unadjusted and adjusted multiple regression analyses showed that LS-SPM patients had a superior survival compared to LUSC-only and OT-LUSC groups.ConclusionLS-SPM patients have a good prognosis with aggressive therapy and immune monitoring. The present study offers novel insights into the pathophysiological causes and treatments for LS-SPM. |
| first_indexed | 2024-03-07T23:37:41Z |
| format | Article |
| id | doaj.art-9bd8a40fe33c4dce8689d03fe37d6d66 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-07T23:37:41Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-9bd8a40fe33c4dce8689d03fe37d6d662024-02-20T05:33:57ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-02-011410.3389/fonc.2024.12943831294383Prognostic analysis of lung squamous cell carcinoma patients with second primary malignancies: a SEER database studyWeiqing Han0Silin Wang1Lang Su2Jianjun Xu3Yiping Wei4Department of Cardiothoracic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Thoracic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Thoracic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Cardiothoracic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaDepartment of Thoracic Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, ChinaBackgroundAs lung squamous cell carcinoma (LUSC) patients are at increased risk of developing a second primary cancer, this complicates the patient’s condition and thus makes prognostic assessment more difficult, posing a significant prognostic challenge for clinicians. Our goal was to assess the prognosis of LUSC patients with a second primary tumor, and provide insights into appropriate therapy and monitoring strategies.MethodsData was obtained for LUSC patients from the Surveillance, Epidemiology, and End Results (SEER) database. The LUSC patients were divided into three groups (LS-SPM, OT-LUSC and LUSC-only). Univariate and stratified analyses were performed for the baseline and clinical characteristics of the participants. Multiple regression and Kaplan-Meier survival analyses were also performed, followed by a final life table analysis.ResultsIn our sample of 101,626 patients, the HR for OS in the LS-SPM group was 0.40 in univariate analysis. Kaplan-Meier survival curves showed that LS-SPM patients had considerably longer lifespans compared to the other groups. The LS-SPM patients had median and mean survival times of 64 months and 89.11 months. Unadjusted and adjusted multiple regression analyses showed that LS-SPM patients had a superior survival compared to LUSC-only and OT-LUSC groups.ConclusionLS-SPM patients have a good prognosis with aggressive therapy and immune monitoring. The present study offers novel insights into the pathophysiological causes and treatments for LS-SPM.https://www.frontiersin.org/articles/10.3389/fonc.2024.1294383/fulllung squamous cell carcinomaSEERsecond primary malignancysurvival timeNSCLC |
| spellingShingle | Weiqing Han Silin Wang Lang Su Jianjun Xu Yiping Wei Prognostic analysis of lung squamous cell carcinoma patients with second primary malignancies: a SEER database study Frontiers in Oncology lung squamous cell carcinoma SEER second primary malignancy survival time NSCLC |
| title | Prognostic analysis of lung squamous cell carcinoma patients with second primary malignancies: a SEER database study |
| title_full | Prognostic analysis of lung squamous cell carcinoma patients with second primary malignancies: a SEER database study |
| title_fullStr | Prognostic analysis of lung squamous cell carcinoma patients with second primary malignancies: a SEER database study |
| title_full_unstemmed | Prognostic analysis of lung squamous cell carcinoma patients with second primary malignancies: a SEER database study |
| title_short | Prognostic analysis of lung squamous cell carcinoma patients with second primary malignancies: a SEER database study |
| title_sort | prognostic analysis of lung squamous cell carcinoma patients with second primary malignancies a seer database study |
| topic | lung squamous cell carcinoma SEER second primary malignancy survival time NSCLC |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1294383/full |
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