Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders?
Sleep plays an essential role in all studied animals with a nervous system. However, sleep deprivation leads to various pathological changes and neurobehavioral problems. Astrocytes are the most abundant cells in the brain and are involved in various important functions, including neurotransmitter a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fncel.2023.1188306/full |
| _version_ | 1797795193430212608 |
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| author | Mengxin Que Yujuan Li Xuan Wang Gaofeng Zhan Xiaoxiao Luo Zhiqiang Zhou |
| author_facet | Mengxin Que Yujuan Li Xuan Wang Gaofeng Zhan Xiaoxiao Luo Zhiqiang Zhou |
| author_sort | Mengxin Que |
| collection | DOAJ |
| description | Sleep plays an essential role in all studied animals with a nervous system. However, sleep deprivation leads to various pathological changes and neurobehavioral problems. Astrocytes are the most abundant cells in the brain and are involved in various important functions, including neurotransmitter and ion homeostasis, synaptic and neuronal modulation, and blood–brain barrier maintenance; furthermore, they are associated with numerous neurodegenerative diseases, pain, and mood disorders. Moreover, astrocytes are increasingly being recognized as vital contributors to the regulation of sleep-wake cycles, both locally and in specific neural circuits. In this review, we begin by describing the role of astrocytes in regulating sleep and circadian rhythms, focusing on: (i) neuronal activity; (ii) metabolism; (iii) the glymphatic system; (iv) neuroinflammation; and (v) astrocyte–microglia cross-talk. Moreover, we review the role of astrocytes in sleep deprivation comorbidities and sleep deprivation-related brain disorders. Finally, we discuss potential interventions targeting astrocytes to prevent or treat sleep deprivation-related brain disorders. Pursuing these questions would pave the way for a deeper understanding of the cellular and neural mechanisms underlying sleep deprivation-comorbid brain disorders. |
| first_indexed | 2024-03-13T03:14:11Z |
| format | Article |
| id | doaj.art-9bd8dd2d58e54e0ea183c5935ee9a4dd |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-03-13T03:14:11Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-9bd8dd2d58e54e0ea183c5935ee9a4dd2023-06-26T05:31:14ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022023-06-011710.3389/fncel.2023.11883061188306Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders?Mengxin Que0Yujuan Li1Xuan Wang2Gaofeng Zhan3Xiaoxiao Luo4Zhiqiang Zhou5Hubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Department of Anesthesiology, Tongji Medical College, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Department of Anesthesiology, Tongji Medical College, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Department of Anesthesiology, Tongji Medical College, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Department of Anesthesiology, Tongji Medical College, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Oncology, Tongji Medical College, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, ChinaHubei Key Laboratory of Geriatric Anesthesia and Perioperative Brain Health, Department of Anesthesiology, Tongji Medical College, Wuhan Clinical Research Center for Geriatric Anesthesia, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, ChinaSleep plays an essential role in all studied animals with a nervous system. However, sleep deprivation leads to various pathological changes and neurobehavioral problems. Astrocytes are the most abundant cells in the brain and are involved in various important functions, including neurotransmitter and ion homeostasis, synaptic and neuronal modulation, and blood–brain barrier maintenance; furthermore, they are associated with numerous neurodegenerative diseases, pain, and mood disorders. Moreover, astrocytes are increasingly being recognized as vital contributors to the regulation of sleep-wake cycles, both locally and in specific neural circuits. In this review, we begin by describing the role of astrocytes in regulating sleep and circadian rhythms, focusing on: (i) neuronal activity; (ii) metabolism; (iii) the glymphatic system; (iv) neuroinflammation; and (v) astrocyte–microglia cross-talk. Moreover, we review the role of astrocytes in sleep deprivation comorbidities and sleep deprivation-related brain disorders. Finally, we discuss potential interventions targeting astrocytes to prevent or treat sleep deprivation-related brain disorders. Pursuing these questions would pave the way for a deeper understanding of the cellular and neural mechanisms underlying sleep deprivation-comorbid brain disorders.https://www.frontiersin.org/articles/10.3389/fncel.2023.1188306/fullastrocytessleep deprivationglymphatic systemneuroinflammationsleep deprivation comorbidity |
| spellingShingle | Mengxin Que Yujuan Li Xuan Wang Gaofeng Zhan Xiaoxiao Luo Zhiqiang Zhou Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders? Frontiers in Cellular Neuroscience astrocytes sleep deprivation glymphatic system neuroinflammation sleep deprivation comorbidity |
| title | Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders? |
| title_full | Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders? |
| title_fullStr | Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders? |
| title_full_unstemmed | Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders? |
| title_short | Role of astrocytes in sleep deprivation: accomplices, resisters, or bystanders? |
| title_sort | role of astrocytes in sleep deprivation accomplices resisters or bystanders |
| topic | astrocytes sleep deprivation glymphatic system neuroinflammation sleep deprivation comorbidity |
| url | https://www.frontiersin.org/articles/10.3389/fncel.2023.1188306/full |
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