Association between polyunsaturated fatty acid intake and infertility among American women aged 20–44 years
BackgroundInfertility is a nationwide public health priority in the U.S. However, few studies have investigated the effects of dietary intake of polyunsaturated fatty acids (PUFAs) on female infertility. This study explored the association between PUFA intake and risk of infertility.MethodsA total o...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.938343/full |
| _version_ | 1828299736417828864 |
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| author | Ruohan Wang Ruohan Wang Ying Feng Jiahe Chen Yingjiao Chen Fang Ma Fang Ma |
| author_facet | Ruohan Wang Ruohan Wang Ying Feng Jiahe Chen Yingjiao Chen Fang Ma Fang Ma |
| author_sort | Ruohan Wang |
| collection | DOAJ |
| description | BackgroundInfertility is a nationwide public health priority in the U.S. However, few studies have investigated the effects of dietary intake of polyunsaturated fatty acids (PUFAs) on female infertility. This study explored the association between PUFA intake and risk of infertility.MethodsA total of 1,785 women aged 20–44 years from three National Health and Nutrition Examination Survey cycles (2013–2018) were included in this cross-sectional study. The intake of PUFAs was obtained from a 24-h dietary interview on two separate days with a 3–10-day interval, and nutrient residue models were used. Fertility status was assessed by positive response to two relative questions via a questionnaire. Logistic regression models were used and some covariates were adjusted.ResultsAmong all the participants, 340 (19.05%) women suffered from infertility. The intake of docosahexaenoic acid (DHA) (OR = 0.998, 95% CI 0.998, 0.009) was slightly related to the risk of infertility. In contrast, women with higher α-linolenic acid (ALA) (OR = 1.416, 95% CI 1.138, 1.763) and linoleic acid (LA) intake (OR = 1.020, 95% CI 1.002, 1.038) presented with a relatively higher risk of primary infertility. Furthermore, in 20–34-year-old women, higher omega-6/omega-3 was significant associated with the risk of infertility (OR = 1.002, 95%CI 1.000, 1.005).ConclusionsOur results suggest that PUFA intake is only slightly associated with infertility. The higher the DHA intake, the lower the risk of infertility regardless of age. In women with primary infertility, ALA and LA has negative effect. |
| first_indexed | 2024-04-13T12:58:47Z |
| format | Article |
| id | doaj.art-9bda1935e76b46c5842e492a4946de18 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-04-13T12:58:47Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-9bda1935e76b46c5842e492a4946de182022-12-22T02:45:58ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-08-011010.3389/fpubh.2022.938343938343Association between polyunsaturated fatty acid intake and infertility among American women aged 20–44 yearsRuohan Wang0Ruohan Wang1Ying Feng2Jiahe Chen3Yingjiao Chen4Fang Ma5Fang Ma6Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, ChinaWest China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, ChinaWest China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu, ChinaOffice for West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, ChinaCenter for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, ChinaDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu, ChinaBackgroundInfertility is a nationwide public health priority in the U.S. However, few studies have investigated the effects of dietary intake of polyunsaturated fatty acids (PUFAs) on female infertility. This study explored the association between PUFA intake and risk of infertility.MethodsA total of 1,785 women aged 20–44 years from three National Health and Nutrition Examination Survey cycles (2013–2018) were included in this cross-sectional study. The intake of PUFAs was obtained from a 24-h dietary interview on two separate days with a 3–10-day interval, and nutrient residue models were used. Fertility status was assessed by positive response to two relative questions via a questionnaire. Logistic regression models were used and some covariates were adjusted.ResultsAmong all the participants, 340 (19.05%) women suffered from infertility. The intake of docosahexaenoic acid (DHA) (OR = 0.998, 95% CI 0.998, 0.009) was slightly related to the risk of infertility. In contrast, women with higher α-linolenic acid (ALA) (OR = 1.416, 95% CI 1.138, 1.763) and linoleic acid (LA) intake (OR = 1.020, 95% CI 1.002, 1.038) presented with a relatively higher risk of primary infertility. Furthermore, in 20–34-year-old women, higher omega-6/omega-3 was significant associated with the risk of infertility (OR = 1.002, 95%CI 1.000, 1.005).ConclusionsOur results suggest that PUFA intake is only slightly associated with infertility. The higher the DHA intake, the lower the risk of infertility regardless of age. In women with primary infertility, ALA and LA has negative effect.https://www.frontiersin.org/articles/10.3389/fpubh.2022.938343/fullinfertilitydocosapentaenoic acidlinoleic acidpolyunsaturated fatty acidsNHANES |
| spellingShingle | Ruohan Wang Ruohan Wang Ying Feng Jiahe Chen Yingjiao Chen Fang Ma Fang Ma Association between polyunsaturated fatty acid intake and infertility among American women aged 20–44 years Frontiers in Public Health infertility docosapentaenoic acid linoleic acid polyunsaturated fatty acids NHANES |
| title | Association between polyunsaturated fatty acid intake and infertility among American women aged 20–44 years |
| title_full | Association between polyunsaturated fatty acid intake and infertility among American women aged 20–44 years |
| title_fullStr | Association between polyunsaturated fatty acid intake and infertility among American women aged 20–44 years |
| title_full_unstemmed | Association between polyunsaturated fatty acid intake and infertility among American women aged 20–44 years |
| title_short | Association between polyunsaturated fatty acid intake and infertility among American women aged 20–44 years |
| title_sort | association between polyunsaturated fatty acid intake and infertility among american women aged 20 44 years |
| topic | infertility docosapentaenoic acid linoleic acid polyunsaturated fatty acids NHANES |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.938343/full |
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