Metabolic reprogramming in cancer: Mechanisms and therapeutics
Abstract Cancer cells characterized by uncontrolled growth and proliferation require altered metabolic processes to maintain this characteristic. Metabolic reprogramming is a process mediated by various factors, including oncogenes, tumor suppressor genes, changes in growth factors, and tumor–host c...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-04-01
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| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.218 |
| _version_ | 1797849251687956480 |
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| author | Shiqi Nong Xiaoyue Han Yu Xiang Yuran Qian Yuhao Wei Tingyue Zhang Keyue Tian Kai Shen Jing Yang Xuelei Ma |
| author_facet | Shiqi Nong Xiaoyue Han Yu Xiang Yuran Qian Yuhao Wei Tingyue Zhang Keyue Tian Kai Shen Jing Yang Xuelei Ma |
| author_sort | Shiqi Nong |
| collection | DOAJ |
| description | Abstract Cancer cells characterized by uncontrolled growth and proliferation require altered metabolic processes to maintain this characteristic. Metabolic reprogramming is a process mediated by various factors, including oncogenes, tumor suppressor genes, changes in growth factors, and tumor–host cell interactions, which help to meet the needs of cancer cell anabolism and promote tumor development. Metabolic reprogramming in tumor cells is dynamically variable, depending on the tumor type and microenvironment, and reprogramming involves multiple metabolic pathways. These metabolic pathways have complex mechanisms and involve the coordination of various signaling molecules, proteins, and enzymes, which increases the resistance of tumor cells to traditional antitumor therapies. With the development of cancer therapies, metabolic reprogramming has been recognized as a new therapeutic target for metabolic changes in tumor cells. Therefore, understanding how multiple metabolic pathways in cancer cells change can provide a reference for the development of new therapies for tumor treatment. Here, we systemically reviewed the metabolic changes and their alteration factors, together with the current tumor regulation treatments and other possible treatments that are still under investigation. Continuous efforts are needed to further explore the mechanism of cancer metabolism reprogramming and corresponding metabolic treatments. |
| first_indexed | 2024-04-09T18:40:52Z |
| format | Article |
| id | doaj.art-9bdbf52d2a544a33b8b88b9590c2249f |
| institution | Directory Open Access Journal |
| issn | 2688-2663 |
| language | English |
| last_indexed | 2024-04-09T18:40:52Z |
| publishDate | 2023-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj.art-9bdbf52d2a544a33b8b88b9590c2249f2023-04-11T05:24:32ZengWileyMedComm2688-26632023-04-0142n/an/a10.1002/mco2.218Metabolic reprogramming in cancer: Mechanisms and therapeuticsShiqi Nong0Xiaoyue Han1Yu Xiang2Yuran Qian3Yuhao Wei4Tingyue Zhang5Keyue Tian6Kai Shen7Jing Yang8Xuelei Ma9State Key Laboratory of Oral Diseases West China Hospital of Stomatology West China School of Stomatology National Clinical Research Center for Oral Diseases Sichuan University Chengdu Sichuan ChinaState Key Laboratory of Oral Diseases West China Hospital of Stomatology West China School of Stomatology National Clinical Research Center for Oral Diseases Sichuan University Chengdu Sichuan ChinaDepartment of Biotherapy Cancer Center West China Hospital Sichuan University Chengdu Sichuan ChinaState Key Laboratory of Oral Diseases West China Hospital of Stomatology West China School of Stomatology National Clinical Research Center for Oral Diseases Sichuan University Chengdu Sichuan ChinaDepartment of Clinical Medicine West China School of Medicine West China Hospital Sichuan University Chengdu Sichuan ChinaState Key Laboratory of Oral Diseases West China Hospital of Stomatology West China School of Stomatology National Clinical Research Center for Oral Diseases Sichuan University Chengdu Sichuan ChinaState Key Laboratory of Oral Diseases West China Hospital of Stomatology West China School of Stomatology National Clinical Research Center for Oral Diseases Sichuan University Chengdu Sichuan ChinaDepartment of Oncology First Affiliated Hospital of Nanjing Medical University Nanjing ChinaState Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou ChinaState Key Laboratory of Oral Diseases West China Hospital of Stomatology West China School of Stomatology National Clinical Research Center for Oral Diseases Sichuan University Chengdu Sichuan ChinaAbstract Cancer cells characterized by uncontrolled growth and proliferation require altered metabolic processes to maintain this characteristic. Metabolic reprogramming is a process mediated by various factors, including oncogenes, tumor suppressor genes, changes in growth factors, and tumor–host cell interactions, which help to meet the needs of cancer cell anabolism and promote tumor development. Metabolic reprogramming in tumor cells is dynamically variable, depending on the tumor type and microenvironment, and reprogramming involves multiple metabolic pathways. These metabolic pathways have complex mechanisms and involve the coordination of various signaling molecules, proteins, and enzymes, which increases the resistance of tumor cells to traditional antitumor therapies. With the development of cancer therapies, metabolic reprogramming has been recognized as a new therapeutic target for metabolic changes in tumor cells. Therefore, understanding how multiple metabolic pathways in cancer cells change can provide a reference for the development of new therapies for tumor treatment. Here, we systemically reviewed the metabolic changes and their alteration factors, together with the current tumor regulation treatments and other possible treatments that are still under investigation. Continuous efforts are needed to further explore the mechanism of cancer metabolism reprogramming and corresponding metabolic treatments.https://doi.org/10.1002/mco2.218cancer metabolismcancer therapyglycolysismetabolic reprogramming |
| spellingShingle | Shiqi Nong Xiaoyue Han Yu Xiang Yuran Qian Yuhao Wei Tingyue Zhang Keyue Tian Kai Shen Jing Yang Xuelei Ma Metabolic reprogramming in cancer: Mechanisms and therapeutics MedComm cancer metabolism cancer therapy glycolysis metabolic reprogramming |
| title | Metabolic reprogramming in cancer: Mechanisms and therapeutics |
| title_full | Metabolic reprogramming in cancer: Mechanisms and therapeutics |
| title_fullStr | Metabolic reprogramming in cancer: Mechanisms and therapeutics |
| title_full_unstemmed | Metabolic reprogramming in cancer: Mechanisms and therapeutics |
| title_short | Metabolic reprogramming in cancer: Mechanisms and therapeutics |
| title_sort | metabolic reprogramming in cancer mechanisms and therapeutics |
| topic | cancer metabolism cancer therapy glycolysis metabolic reprogramming |
| url | https://doi.org/10.1002/mco2.218 |
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