Integrative analysis of chromatin accessibility and transcriptome landscapes in the induction of peritoneal fibrosis by high glucose

Integrative analysis of chromatin accessibility and transcriptome landscapes in the induction of peritoneal fibrosis by high glucose

Abstract Background Peritoneal fibrosis is the prevailing complication induced by prolonged exposure to high glucose in patients undergoing peritoneal dialysis. Methods To elucidate the molecular mechanisms underlying this process, we conducted an integrated analysis of the transcriptome and chromat...

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Bibliographic Details
Main Authors: Qiong Song, Pengbo Wang, Huan Wang, Meijing Pan, Xiujuan Li, Zhuan’e Yao, Wei Wang, Guangbo Tang, Sen Zhou
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Journal of Translational Medicine
Subjects:
End-stage kidney disease
High glucose
Peritoneal fibrosis
Chromatin accessibility
Transcriptome landscapes
HIF-1α
Online Access:https://doi.org/10.1186/s12967-024-05037-6

Internet

https://doi.org/10.1186/s12967-024-05037-6

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