Nontuberculous Mycobacteria, Zambia
Clinical relevance of nontuberculous mycobacteria (NTM) isolated from 180 chronically ill patients and 385 healthy controls in Zambia was evaluated to examine the contribution of these isolates to tuberculosis (TB)–like disease. The proportion of NTM-positive sputum samples was significantly higher...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2009-02-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/15/2/08-0006_article |
| _version_ | 1818974017406631936 |
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| author | Patricia C.A.M. Buijtels Marianne A.B. van der Sande Cas S. de Graaff Shelagh Parkinson Henri A. Verbrugh Pieter L.C. Petit Dick van Soolingen |
| author_facet | Patricia C.A.M. Buijtels Marianne A.B. van der Sande Cas S. de Graaff Shelagh Parkinson Henri A. Verbrugh Pieter L.C. Petit Dick van Soolingen |
| author_sort | Patricia C.A.M. Buijtels |
| collection | DOAJ |
| description | Clinical relevance of nontuberculous mycobacteria (NTM) isolated from 180 chronically ill patients and 385 healthy controls in Zambia was evaluated to examine the contribution of these isolates to tuberculosis (TB)–like disease. The proportion of NTM-positive sputum samples was significantly higher in the patient group than in controls; 11% and 6%, respectively (p<0.05). NTM-associated lung disease was diagnosed for 1 patient, and a probable diagnosis was made for 3 patients. NTM-positive patients and controls were more likely to report vomiting and diarrhea and were more frequently underweight than the NTM-negative patients and controls. Chest radiographs of NTM-positive patients showed deviations consistent with TB more frequently than those of controls. The most frequently isolated NTM was Mycobacterium avium complex. Multiple, not previously identified mycobacteria (55 of 171 NTM) were isolated from both groups. NTM probably play an important role in the etiology of TB-like diseases in Zambia. |
| first_indexed | 2024-12-20T15:33:22Z |
| format | Article |
| id | doaj.art-9bdd15f1b9d94165bee603ab39738665 |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-20T15:33:22Z |
| publishDate | 2009-02-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-9bdd15f1b9d94165bee603ab397386652022-12-21T19:35:32ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592009-02-0115224224910.3201/eid1502.080006Nontuberculous Mycobacteria, ZambiaPatricia C.A.M. BuijtelsMarianne A.B. van der SandeCas S. de GraaffShelagh ParkinsonHenri A. VerbrughPieter L.C. PetitDick van SoolingenClinical relevance of nontuberculous mycobacteria (NTM) isolated from 180 chronically ill patients and 385 healthy controls in Zambia was evaluated to examine the contribution of these isolates to tuberculosis (TB)–like disease. The proportion of NTM-positive sputum samples was significantly higher in the patient group than in controls; 11% and 6%, respectively (p<0.05). NTM-associated lung disease was diagnosed for 1 patient, and a probable diagnosis was made for 3 patients. NTM-positive patients and controls were more likely to report vomiting and diarrhea and were more frequently underweight than the NTM-negative patients and controls. Chest radiographs of NTM-positive patients showed deviations consistent with TB more frequently than those of controls. The most frequently isolated NTM was Mycobacterium avium complex. Multiple, not previously identified mycobacteria (55 of 171 NTM) were isolated from both groups. NTM probably play an important role in the etiology of TB-like diseases in Zambia.https://wwwnc.cdc.gov/eid/article/15/2/08-0006_articleTuberculosisnontuberculous mycobacteriaclinical relevancediagnosisAfricaZambia |
| spellingShingle | Patricia C.A.M. Buijtels Marianne A.B. van der Sande Cas S. de Graaff Shelagh Parkinson Henri A. Verbrugh Pieter L.C. Petit Dick van Soolingen Nontuberculous Mycobacteria, Zambia Emerging Infectious Diseases Tuberculosis nontuberculous mycobacteria clinical relevance diagnosis Africa Zambia |
| title | Nontuberculous Mycobacteria, Zambia |
| title_full | Nontuberculous Mycobacteria, Zambia |
| title_fullStr | Nontuberculous Mycobacteria, Zambia |
| title_full_unstemmed | Nontuberculous Mycobacteria, Zambia |
| title_short | Nontuberculous Mycobacteria, Zambia |
| title_sort | nontuberculous mycobacteria zambia |
| topic | Tuberculosis nontuberculous mycobacteria clinical relevance diagnosis Africa Zambia |
| url | https://wwwnc.cdc.gov/eid/article/15/2/08-0006_article |
| work_keys_str_mv | AT patriciacambuijtels nontuberculousmycobacteriazambia AT marianneabvandersande nontuberculousmycobacteriazambia AT cassdegraaff nontuberculousmycobacteriazambia AT shelaghparkinson nontuberculousmycobacteriazambia AT henriaverbrugh nontuberculousmycobacteriazambia AT pieterlcpetit nontuberculousmycobacteriazambia AT dickvansoolingen nontuberculousmycobacteriazambia |