Elevation of dopamine level reduces host-seeking activity in the adult female mosquito <it>Aedes albopictus</it>
<p>Abstract</p> <p>Background</p> <p>Mosquito-borne viruses are transmitted to human hosts <it>via</it> blood-feeding behavior of female mosquitoes. Female mosquitoes seek a host to take blood meals (host-seeking behavior). In order to prevent virus infectio...
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| Format: | Article |
| Language: | English |
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BMC
2012-05-01
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| Series: | Parasites & Vectors |
| Subjects: | |
| Online Access: | http://www.parasitesandvectors.com/content/5/1/92 |
| _version_ | 1818150205915136000 |
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| author | Fukumitsu Yuki Irie Keiichi Satho Tomomitsu Aonuma Hitoshi Dieng Hamady Ahmad Abu Nakashima Yukihiko Mishima Kenichi Kashige Nobuhiro Miake Fumio |
| author_facet | Fukumitsu Yuki Irie Keiichi Satho Tomomitsu Aonuma Hitoshi Dieng Hamady Ahmad Abu Nakashima Yukihiko Mishima Kenichi Kashige Nobuhiro Miake Fumio |
| author_sort | Fukumitsu Yuki |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Mosquito-borne viruses are transmitted to human hosts <it>via</it> blood-feeding behavior of female mosquitoes. Female mosquitoes seek a host to take blood meals (host-seeking behavior). In order to prevent virus infections, it is important to understand how they modulate host-seeking behavior. Dopamine (DA) in the central nervous system acts as a neuromediator that regulates a variety of behaviors in insects. In female mosquitoes, host-seeking behavior increases when DA levels in the head decline after emergence. However, it remains unclear whether DA directly modulates host-seeking behavior in female mosquitoes. The aim of this study was to examine whether changes in DA levels in the head affects host-seeking activity in the adult female mosquito <it>Aedes albopictus</it> (<it>Ae. albopictus</it>).</p> <p>Findings</p> <p>We compared host-seeking behavior in one group of emerging female adults treated with <smcaps>l</smcaps>-β-3,4-dihydroxyphenylalanine (<smcaps>l</smcaps>-DOPA), the precursor of DA, (<smcaps>l</smcaps>-DOPA group), with that in an untreated control (control group) after confirming elevation of head DA in <smcaps>l</smcaps>-DOPA group by using high-performance liquid chromatography. The content of head DA in <smcaps>l</smcaps>-DOPA group significantly remained higher than that in controls on all days examined. The host-seeking activity in the control group showed a gradual increase over the 6-day experimental period. In contrast, there was no such increase in the host-seeking activity in the <smcaps>l</smcaps>-DOPA group. Therefore, the host-seeking activity of <smcaps>l</smcaps>-DOPA group was significantly lower than that of the controls between day 3 and 6 post-emergence.</p> <p>Conclusion</p> <p>Our results indicate that elevation of DA level reduces host-seeking activity in adult female mosquito <it>Ae. albopictus</it>.</p> |
| first_indexed | 2024-12-11T13:19:14Z |
| format | Article |
| id | doaj.art-9bde0a3781dd4d0a8321b492449cc7ce |
| institution | Directory Open Access Journal |
| issn | 1756-3305 |
| language | English |
| last_indexed | 2024-12-11T13:19:14Z |
| publishDate | 2012-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Parasites & Vectors |
| spelling | doaj.art-9bde0a3781dd4d0a8321b492449cc7ce2022-12-22T01:05:55ZengBMCParasites & Vectors1756-33052012-05-01519210.1186/1756-3305-5-92Elevation of dopamine level reduces host-seeking activity in the adult female mosquito <it>Aedes albopictus</it>Fukumitsu YukiIrie KeiichiSatho TomomitsuAonuma HitoshiDieng HamadyAhmad AbuNakashima YukihikoMishima KenichiKashige NobuhiroMiake Fumio<p>Abstract</p> <p>Background</p> <p>Mosquito-borne viruses are transmitted to human hosts <it>via</it> blood-feeding behavior of female mosquitoes. Female mosquitoes seek a host to take blood meals (host-seeking behavior). In order to prevent virus infections, it is important to understand how they modulate host-seeking behavior. Dopamine (DA) in the central nervous system acts as a neuromediator that regulates a variety of behaviors in insects. In female mosquitoes, host-seeking behavior increases when DA levels in the head decline after emergence. However, it remains unclear whether DA directly modulates host-seeking behavior in female mosquitoes. The aim of this study was to examine whether changes in DA levels in the head affects host-seeking activity in the adult female mosquito <it>Aedes albopictus</it> (<it>Ae. albopictus</it>).</p> <p>Findings</p> <p>We compared host-seeking behavior in one group of emerging female adults treated with <smcaps>l</smcaps>-β-3,4-dihydroxyphenylalanine (<smcaps>l</smcaps>-DOPA), the precursor of DA, (<smcaps>l</smcaps>-DOPA group), with that in an untreated control (control group) after confirming elevation of head DA in <smcaps>l</smcaps>-DOPA group by using high-performance liquid chromatography. The content of head DA in <smcaps>l</smcaps>-DOPA group significantly remained higher than that in controls on all days examined. The host-seeking activity in the control group showed a gradual increase over the 6-day experimental period. In contrast, there was no such increase in the host-seeking activity in the <smcaps>l</smcaps>-DOPA group. Therefore, the host-seeking activity of <smcaps>l</smcaps>-DOPA group was significantly lower than that of the controls between day 3 and 6 post-emergence.</p> <p>Conclusion</p> <p>Our results indicate that elevation of DA level reduces host-seeking activity in adult female mosquito <it>Ae. albopictus</it>.</p>http://www.parasitesandvectors.com/content/5/1/92Host-seeking behaviorDopamine<it>Aedes albopictus</it> |
| spellingShingle | Fukumitsu Yuki Irie Keiichi Satho Tomomitsu Aonuma Hitoshi Dieng Hamady Ahmad Abu Nakashima Yukihiko Mishima Kenichi Kashige Nobuhiro Miake Fumio Elevation of dopamine level reduces host-seeking activity in the adult female mosquito <it>Aedes albopictus</it> Parasites & Vectors Host-seeking behavior Dopamine <it>Aedes albopictus</it> |
| title | Elevation of dopamine level reduces host-seeking activity in the adult female mosquito <it>Aedes albopictus</it> |
| title_full | Elevation of dopamine level reduces host-seeking activity in the adult female mosquito <it>Aedes albopictus</it> |
| title_fullStr | Elevation of dopamine level reduces host-seeking activity in the adult female mosquito <it>Aedes albopictus</it> |
| title_full_unstemmed | Elevation of dopamine level reduces host-seeking activity in the adult female mosquito <it>Aedes albopictus</it> |
| title_short | Elevation of dopamine level reduces host-seeking activity in the adult female mosquito <it>Aedes albopictus</it> |
| title_sort | elevation of dopamine level reduces host seeking activity in the adult female mosquito it aedes albopictus it |
| topic | Host-seeking behavior Dopamine <it>Aedes albopictus</it> |
| url | http://www.parasitesandvectors.com/content/5/1/92 |
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