Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?
Vascular Calcification (VC), low bone mass and fragility fractures are frequently observed in ageing subjects. Although this clinical observation could be the mere coincidence of frequent age-dependent disorders, clinical and experimental data suggest that VC and bone loss could share pathophysiolog...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/11/3835 |
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| author | Jorge B. Cannata-Andía Natalia Carrillo-López Osvaldo D. Messina Neveen A. T. Hamdy Sara Panizo Serge L. Ferrari on behalf of the International Osteoporosis Foundation (IOF) Working Group on Bone and Cardiovascular Diseases |
| author_facet | Jorge B. Cannata-Andía Natalia Carrillo-López Osvaldo D. Messina Neveen A. T. Hamdy Sara Panizo Serge L. Ferrari on behalf of the International Osteoporosis Foundation (IOF) Working Group on Bone and Cardiovascular Diseases |
| author_sort | Jorge B. Cannata-Andía |
| collection | DOAJ |
| description | Vascular Calcification (VC), low bone mass and fragility fractures are frequently observed in ageing subjects. Although this clinical observation could be the mere coincidence of frequent age-dependent disorders, clinical and experimental data suggest that VC and bone loss could share pathophysiological mechanisms. Indeed, VC is an active process of calcium and phosphate precipitation that involves the transition of the vascular smooth muscle cells (VSMCs) into osteoblast-like cells. Among the molecules involved in this process, parathyroid hormone (PTH) plays a key role acting through several mechanisms which includes the regulation of the RANK/RANKL/OPG system and the Wnt/ß-catenin pathway, the main pathways for bone resorption and bone formation, respectively. Furthermore, some microRNAs have been implicated as common regulators of bone metabolism, VC, left ventricle hypertrophy and myocardial fibrosis. Elucidating the common mechanisms between ageing; VC and bone loss could help to better understand the potential effects of osteoporosis drugs on the CV system. |
| first_indexed | 2024-03-10T05:12:04Z |
| format | Article |
| id | doaj.art-9bdec82e057a4d86a952598e80781662 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T05:12:04Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-9bdec82e057a4d86a952598e807816622023-11-23T00:46:37ZengMDPI AGNutrients2072-66432021-10-011311383510.3390/nu13113835Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing?Jorge B. Cannata-Andía0Natalia Carrillo-López1Osvaldo D. Messina2Neveen A. T. Hamdy3Sara Panizo4Serge L. Ferrari5on behalf of the International Osteoporosis Foundation (IOF) Working Group on Bone and Cardiovascular Diseases6Bone and Mineral Research Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Hospital Universitario Central de Asturias, 33011 Oviedo, SpainBone and Mineral Research Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Hospital Universitario Central de Asturias, 33011 Oviedo, SpainInvestigaciones Reumatológicas y Osteológicas (IRO), Buenos Aires 1114, ArgentinaCenter for Bone Quality, Division Endocrinology, Department of Medicine, Leiden University Medical Center, 2333 ZA Leiden, The NetherlandsBone and Mineral Research Unit, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Retic REDinREN-ISCIII, Hospital Universitario Central de Asturias, 33011 Oviedo, SpainService and Laboratory of Bone Diseases, Department of Medicine, Faculty of Medicine, Geneva University Hospital, 1211 Geneva, SwitzerlandInternational Osteoporosis Foundation, 1260 Nyon, SwitzerlandVascular Calcification (VC), low bone mass and fragility fractures are frequently observed in ageing subjects. Although this clinical observation could be the mere coincidence of frequent age-dependent disorders, clinical and experimental data suggest that VC and bone loss could share pathophysiological mechanisms. Indeed, VC is an active process of calcium and phosphate precipitation that involves the transition of the vascular smooth muscle cells (VSMCs) into osteoblast-like cells. Among the molecules involved in this process, parathyroid hormone (PTH) plays a key role acting through several mechanisms which includes the regulation of the RANK/RANKL/OPG system and the Wnt/ß-catenin pathway, the main pathways for bone resorption and bone formation, respectively. Furthermore, some microRNAs have been implicated as common regulators of bone metabolism, VC, left ventricle hypertrophy and myocardial fibrosis. Elucidating the common mechanisms between ageing; VC and bone loss could help to better understand the potential effects of osteoporosis drugs on the CV system.https://www.mdpi.com/2072-6643/13/11/3835osteoporosisvascular calcificationmineral bone disordersbone lossbone fracturesfracture risk |
| spellingShingle | Jorge B. Cannata-Andía Natalia Carrillo-López Osvaldo D. Messina Neveen A. T. Hamdy Sara Panizo Serge L. Ferrari on behalf of the International Osteoporosis Foundation (IOF) Working Group on Bone and Cardiovascular Diseases Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing? Nutrients osteoporosis vascular calcification mineral bone disorders bone loss bone fractures fracture risk |
| title | Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing? |
| title_full | Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing? |
| title_fullStr | Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing? |
| title_full_unstemmed | Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing? |
| title_short | Pathophysiology of Vascular Calcification and Bone Loss: Linked Disorders of Ageing? |
| title_sort | pathophysiology of vascular calcification and bone loss linked disorders of ageing |
| topic | osteoporosis vascular calcification mineral bone disorders bone loss bone fractures fracture risk |
| url | https://www.mdpi.com/2072-6643/13/11/3835 |
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