Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila
Neurofibromatosis type 1 (NF1) is a genetic disorder caused by mutations in neurofibromin and associated with disruptions in physiology and behavior. Here the authors show that neurofibromin regulates metabolic homeostasis via a discrete brain circuit in a Drosophila model of NF1.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24505-x |
| _version_ | 1818991230082613248 |
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| author | Valentina Botero Bethany A. Stanhope Elizabeth B. Brown Eliza C. Grenci Tamara Boto Scarlet J. Park Lanikea B. King Keith R. Murphy Kenneth J. Colodner James A. Walker Alex C. Keene William W. Ja Seth M. Tomchik |
| author_facet | Valentina Botero Bethany A. Stanhope Elizabeth B. Brown Eliza C. Grenci Tamara Boto Scarlet J. Park Lanikea B. King Keith R. Murphy Kenneth J. Colodner James A. Walker Alex C. Keene William W. Ja Seth M. Tomchik |
| author_sort | Valentina Botero |
| collection | DOAJ |
| description | Neurofibromatosis type 1 (NF1) is a genetic disorder caused by mutations in neurofibromin and associated with disruptions in physiology and behavior. Here the authors show that neurofibromin regulates metabolic homeostasis via a discrete brain circuit in a Drosophila model of NF1. |
| first_indexed | 2024-12-20T20:06:57Z |
| format | Article |
| id | doaj.art-9bdfedfd53ef4415959b9f694b37b1af |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:06:57Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-9bdfedfd53ef4415959b9f694b37b1af2022-12-21T19:27:56ZengNature PortfolioNature Communications2041-17232021-07-0112111310.1038/s41467-021-24505-xNeurofibromin regulates metabolic rate via neuronal mechanisms in DrosophilaValentina Botero0Bethany A. Stanhope1Elizabeth B. Brown2Eliza C. Grenci3Tamara Boto4Scarlet J. Park5Lanikea B. King6Keith R. Murphy7Kenneth J. Colodner8James A. Walker9Alex C. Keene10William W. Ja11Seth M. Tomchik12Department of Neuroscience, The Scripps Research Institute, Scripps FloridaDepartment of Biological Sciences, Florida Atlantic UniversityDepartment of Biological Sciences, Florida Atlantic UniversityDepartment of Neuroscience, The Scripps Research Institute, Scripps FloridaDepartment of Neuroscience, The Scripps Research Institute, Scripps FloridaDepartment of Neuroscience, The Scripps Research Institute, Scripps FloridaDepartment of Neuroscience, The Scripps Research Institute, Scripps FloridaDepartment of Neuroscience, The Scripps Research Institute, Scripps FloridaProgram in Neuroscience and Behavior, Mount Holyoke CollegeCenter for Genomic Medicine, Massachusetts General Hospital, Harvard Medical SchoolDepartment of Biological Sciences, Florida Atlantic UniversityDepartment of Neuroscience, The Scripps Research Institute, Scripps FloridaDepartment of Neuroscience, The Scripps Research Institute, Scripps FloridaNeurofibromatosis type 1 (NF1) is a genetic disorder caused by mutations in neurofibromin and associated with disruptions in physiology and behavior. Here the authors show that neurofibromin regulates metabolic homeostasis via a discrete brain circuit in a Drosophila model of NF1.https://doi.org/10.1038/s41467-021-24505-x |
| spellingShingle | Valentina Botero Bethany A. Stanhope Elizabeth B. Brown Eliza C. Grenci Tamara Boto Scarlet J. Park Lanikea B. King Keith R. Murphy Kenneth J. Colodner James A. Walker Alex C. Keene William W. Ja Seth M. Tomchik Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila Nature Communications |
| title | Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila |
| title_full | Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila |
| title_fullStr | Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila |
| title_full_unstemmed | Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila |
| title_short | Neurofibromin regulates metabolic rate via neuronal mechanisms in Drosophila |
| title_sort | neurofibromin regulates metabolic rate via neuronal mechanisms in drosophila |
| url | https://doi.org/10.1038/s41467-021-24505-x |
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