The effect of heart failure and left ventricular assist device treatment on right ventricular mechanics: a computational study
Abstract Background and aims Although it is important to analyze the hemodynamic factors related to the right ventricle (RV) after left ventricular assist device (LVAD) implantation, previous studies have focused only on the alteration of the ventricular shape and lack quantitative analysis of the v...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | BioMedical Engineering OnLine |
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| Online Access: | http://link.springer.com/article/10.1186/s12938-018-0498-0 |
| _version_ | 1818591581120233472 |
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| author | Jun I. K. Park Aulia Khamas Heikhmakhtiar Chang Hyun Kim Yoo Seok Kim Seong Wook Choi Kwang Soup Song Ki Moo Lim |
| author_facet | Jun I. K. Park Aulia Khamas Heikhmakhtiar Chang Hyun Kim Yoo Seok Kim Seong Wook Choi Kwang Soup Song Ki Moo Lim |
| author_sort | Jun I. K. Park |
| collection | DOAJ |
| description | Abstract Background and aims Although it is important to analyze the hemodynamic factors related to the right ventricle (RV) after left ventricular assist device (LVAD) implantation, previous studies have focused only on the alteration of the ventricular shape and lack quantitative analysis of the various hemodynamic parameters. Therefore, we quantitatively analyzed various hemodynamic parameters related to the RV under normal, heart failure (HF), and HF incorporated with continuous flow LVAD therapy by using a computational model. Methods In this study, we combined a three-dimensional finite element electromechanical model of ventricles, which is based on human ventricular morphology captured by magnetic resonance imaging (MRI) with a lumped model of the circulatory system and continuous flow LVAD function in order to construct an integrated model of an LVAD implanted-cardiovascular system. To induce systolic dysfunction, the magnitude of the calcium transient function under HF condition was reduced to 70% of the normal value, and the time constant was reduced by 30% of the normal value. Results Under the HF condition, the left ventricular end systolic pressure decreased, the left ventricular end diastolic pressure increased, and the pressure in the right atrium (RA), RV, and pulmonary artery (PA) increased compared with the normal condition. The LVAD therapy decreased the end-systolic pressure of the LV by 41%, RA by 29%, RV by 53%, and PA by 71%, but increased the right ventricular ejection fraction by 52% and cardiac output by 40%, while the stroke work was reduced by 67% compared with the HF condition without LVAD. The end-systolic ventricular tension and strain decreased with the LVAD treatment. Conclusion LVAD enhances CO and mechanical unloading of the LV as well as those of the RV and prevents pulmonary hypertension which can be induced by HF. |
| first_indexed | 2024-12-16T10:14:42Z |
| format | Article |
| id | doaj.art-9be0b182eb464b09a6de9b827c8fcc2c |
| institution | Directory Open Access Journal |
| issn | 1475-925X |
| language | English |
| last_indexed | 2024-12-16T10:14:42Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BioMedical Engineering OnLine |
| spelling | doaj.art-9be0b182eb464b09a6de9b827c8fcc2c2022-12-21T22:35:28ZengBMCBioMedical Engineering OnLine1475-925X2018-05-0117111310.1186/s12938-018-0498-0The effect of heart failure and left ventricular assist device treatment on right ventricular mechanics: a computational studyJun I. K. Park0Aulia Khamas Heikhmakhtiar1Chang Hyun Kim2Yoo Seok Kim3Seong Wook Choi4Kwang Soup Song5Ki Moo Lim6Department of IT Convergence Engineering, Kumoh National Institute of TechnologyDepartment of IT Convergence Engineering, Kumoh National Institute of TechnologyDepartment of IT Convergence Engineering, Kumoh National Institute of TechnologyDepartment of IT Convergence Engineering, Kumoh National Institute of TechnologyDepartment of Mechanical & Biomedical Engineering, Kangwon National UniversityDepartment of Medical IT Convergence Engineering, Kumoh National Institute of TechnologyDepartment of IT Convergence Engineering, Kumoh National Institute of TechnologyAbstract Background and aims Although it is important to analyze the hemodynamic factors related to the right ventricle (RV) after left ventricular assist device (LVAD) implantation, previous studies have focused only on the alteration of the ventricular shape and lack quantitative analysis of the various hemodynamic parameters. Therefore, we quantitatively analyzed various hemodynamic parameters related to the RV under normal, heart failure (HF), and HF incorporated with continuous flow LVAD therapy by using a computational model. Methods In this study, we combined a three-dimensional finite element electromechanical model of ventricles, which is based on human ventricular morphology captured by magnetic resonance imaging (MRI) with a lumped model of the circulatory system and continuous flow LVAD function in order to construct an integrated model of an LVAD implanted-cardiovascular system. To induce systolic dysfunction, the magnitude of the calcium transient function under HF condition was reduced to 70% of the normal value, and the time constant was reduced by 30% of the normal value. Results Under the HF condition, the left ventricular end systolic pressure decreased, the left ventricular end diastolic pressure increased, and the pressure in the right atrium (RA), RV, and pulmonary artery (PA) increased compared with the normal condition. The LVAD therapy decreased the end-systolic pressure of the LV by 41%, RA by 29%, RV by 53%, and PA by 71%, but increased the right ventricular ejection fraction by 52% and cardiac output by 40%, while the stroke work was reduced by 67% compared with the HF condition without LVAD. The end-systolic ventricular tension and strain decreased with the LVAD treatment. Conclusion LVAD enhances CO and mechanical unloading of the LV as well as those of the RV and prevents pulmonary hypertension which can be induced by HF.http://link.springer.com/article/10.1186/s12938-018-0498-0Heart failureLeft ventricular assist deviceElectromechanical modelRight ventricle |
| spellingShingle | Jun I. K. Park Aulia Khamas Heikhmakhtiar Chang Hyun Kim Yoo Seok Kim Seong Wook Choi Kwang Soup Song Ki Moo Lim The effect of heart failure and left ventricular assist device treatment on right ventricular mechanics: a computational study BioMedical Engineering OnLine Heart failure Left ventricular assist device Electromechanical model Right ventricle |
| title | The effect of heart failure and left ventricular assist device treatment on right ventricular mechanics: a computational study |
| title_full | The effect of heart failure and left ventricular assist device treatment on right ventricular mechanics: a computational study |
| title_fullStr | The effect of heart failure and left ventricular assist device treatment on right ventricular mechanics: a computational study |
| title_full_unstemmed | The effect of heart failure and left ventricular assist device treatment on right ventricular mechanics: a computational study |
| title_short | The effect of heart failure and left ventricular assist device treatment on right ventricular mechanics: a computational study |
| title_sort | effect of heart failure and left ventricular assist device treatment on right ventricular mechanics a computational study |
| topic | Heart failure Left ventricular assist device Electromechanical model Right ventricle |
| url | http://link.springer.com/article/10.1186/s12938-018-0498-0 |
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