Genetic and Molecular Basis of Heterogeneous NK Cell Responses against Acute Leukemia

Genetic and Molecular Basis of Heterogeneous NK Cell Responses against Acute Leukemia

Natural killer (NK) cells are key cytotoxic effectors against malignant cells. Polygenic and polymorphic Killer cell Immunoglobulin-like Receptor (KIR) and HLA genes participate in the structural and functional formation of the NK cell repertoire. In this study, we extensively investigated the anti-...

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Bibliographic Details
Main Authors: Dhon Roméo Makanga, Francesca Da Rin de Lorenzo, Gaëlle David, Catherine Willem, Léa Dubreuil, Nolwenn Legrand, Thierry Guillaume, Pierre Peterlin, Amandine Lebourgeois, Marie Christine Béné, Alice Garnier, Patrice Chevallier, Ketevan Gendzekhadze, Anne Cesbron, Katia Gagne, Béatrice Clemenceau, Christelle Retière
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cancers
Subjects:
KIR
HLA
natural killer cells
repertoire
acute leukemia
CMV
Online Access:https://www.mdpi.com/2072-6694/12/7/1927

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