Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort
Background Low birth weight has been inconsistently associated with risk of developing affective disorders, including major depressive disorder (MDD). To date, studies investi...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2016-01-01
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| Series: | BJPsych Open |
| Online Access: | https://www.cambridge.org/core/product/identifier/S2056472400001137/type/journal_article |
| _version_ | 1811157107534200832 |
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| author | Donald M. Lyall Hazel M. Inskip Daniel Mackay Ian J. Deary Andrew M. McIntosh Matthew Hotopf Tony Kendrick Jill P. Pell Daniel J. Smith |
| author_facet | Donald M. Lyall Hazel M. Inskip Daniel Mackay Ian J. Deary Andrew M. McIntosh Matthew Hotopf Tony Kendrick Jill P. Pell Daniel J. Smith |
| author_sort | Donald M. Lyall |
| collection | DOAJ |
| description |
Background
Low birth weight has been inconsistently associated with risk of
developing affective disorders, including major depressive disorder
(MDD). To date, studies investigating possible associations between birth
weight and bipolar disorder (BD), or personality traits known to
predispose to affective disorders such as neuroticism, have not been
conducted in large cohorts.
Aims
To assess whether very low birth weight (<1500 g) and low birth weight
(1500–2490 g) were associated with higher neuroticism scores assessed in
middle age, and lifetime history of either MDD or BD. We controlled for
possible confounding factors.
Method
Retrospective cohort study using baseline data on the 83 545 UK Biobank
participants with detailed mental health and birth weight data. Main
outcomes were prevalent MDD and BD, and neuroticism assessed using the
Eysenck Personality Inventory Neuroticism scale - Revised (EPIN-R)
Results
Referent to normal birth weight, very low/low birth weight were
associated with higher neuroticism scores, increased MDD and BD. The
associations between birth weight category and MDD were partially
mediated by higher neuroticism.
Conclusions
These findings suggest that intrauterine programming may play a role in
lifetime vulnerability to affective disorders.
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| first_indexed | 2024-04-10T05:01:33Z |
| format | Article |
| id | doaj.art-9be357c994e943f58b1c8296aa9bb767 |
| institution | Directory Open Access Journal |
| issn | 2056-4724 |
| language | English |
| last_indexed | 2024-04-10T05:01:33Z |
| publishDate | 2016-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | BJPsych Open |
| spelling | doaj.art-9be357c994e943f58b1c8296aa9bb7672023-03-09T12:28:36ZengCambridge University PressBJPsych Open2056-47242016-01-012384410.1192/bjpo.bp.115.002154Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohortDonald M. Lyall0Hazel M. Inskip1Daniel Mackay2Ian J. Deary3Andrew M. McIntosh4Matthew Hotopf5Tony Kendrick6Jill P. Pell7Daniel J. Smith8Institute of Health & Wellbeing, University of Glasgow, Glasgow, UKMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UKInstitute of Health & Wellbeing, University of Glasgow, Glasgow, UKCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UKCentre for Cognitive Ageing and Cognitive Epidemiology, Department of Psychology, University of Edinburgh, Edinburgh, UK, Division of Psychiatry, University of Edinburgh, Edinburgh, UKDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UKPrimary Medical Care Group, University of Southampton, Southampton, UKInstitute of Health & Wellbeing, University of Glasgow, Glasgow, UKInstitute of Health & Wellbeing, University of Glasgow, Glasgow, UK Background Low birth weight has been inconsistently associated with risk of developing affective disorders, including major depressive disorder (MDD). To date, studies investigating possible associations between birth weight and bipolar disorder (BD), or personality traits known to predispose to affective disorders such as neuroticism, have not been conducted in large cohorts. Aims To assess whether very low birth weight (<1500 g) and low birth weight (1500–2490 g) were associated with higher neuroticism scores assessed in middle age, and lifetime history of either MDD or BD. We controlled for possible confounding factors. Method Retrospective cohort study using baseline data on the 83 545 UK Biobank participants with detailed mental health and birth weight data. Main outcomes were prevalent MDD and BD, and neuroticism assessed using the Eysenck Personality Inventory Neuroticism scale - Revised (EPIN-R) Results Referent to normal birth weight, very low/low birth weight were associated with higher neuroticism scores, increased MDD and BD. The associations between birth weight category and MDD were partially mediated by higher neuroticism. Conclusions These findings suggest that intrauterine programming may play a role in lifetime vulnerability to affective disorders. https://www.cambridge.org/core/product/identifier/S2056472400001137/type/journal_article |
| spellingShingle | Donald M. Lyall Hazel M. Inskip Daniel Mackay Ian J. Deary Andrew M. McIntosh Matthew Hotopf Tony Kendrick Jill P. Pell Daniel J. Smith Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort BJPsych Open |
| title | Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort |
| title_full | Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort |
| title_fullStr | Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort |
| title_full_unstemmed | Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort |
| title_short | Low birth weight and features of neuroticism and mood disorder in 83 545 participants of the UK Biobank cohort |
| title_sort | low birth weight and features of neuroticism and mood disorder in 83 545 participants of the uk biobank cohort |
| url | https://www.cambridge.org/core/product/identifier/S2056472400001137/type/journal_article |
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