VRK1 Kinase Activity Modulating Histone H4K16 Acetylation Inhibited by SIRT2 and VRK-IN-1

VRK1 Kinase Activity Modulating Histone H4K16 Acetylation Inhibited by SIRT2 and VRK-IN-1

The accessibility of DNA to different cellular functions requires a dynamic regulation of chromatin organization that is mediated by different epigenetic modifications, which regulate chromatin accessibility and degree of compaction. These epigenetic modifications, particularly the acetylation of hi...

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Bibliographic Details
Main Authors: Eva Monte-Serrano, Pedro A. Lazo
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
VRK1
VRK-IN-1
SIRT2
DNA damage response
histone H4
acetylation
Online Access:https://www.mdpi.com/1422-0067/24/5/4912

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