Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats?
Objectives Cisplatin is an antineoplastic agent, used in the treatment of different types of malignant neoplasms. Side effects such as ototoxicity, nephrotoxicity, and bone marrow toxicity are the main limitations of its clinical use. The aim of the present study was to evaluate the possible effects...
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| Format: | Article |
| Language: | English |
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Korean Society of Otorhinolaryngology-Head and Neck Surgery
2019-02-01
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| Series: | Clinical and Experimental Otorhinolaryngology |
| Subjects: | |
| Online Access: | http://www.e-ceo.org/upload/pdf/ceo-2017-01704.pdf |
| _version_ | 1830403857672306688 |
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| author | H. Bengu Cobanoglu Erkan Vuralkan Abdullah Arslan Bengusu Mirasoglu A. Savas Toklu |
| author_facet | H. Bengu Cobanoglu Erkan Vuralkan Abdullah Arslan Bengusu Mirasoglu A. Savas Toklu |
| author_sort | H. Bengu Cobanoglu |
| collection | DOAJ |
| description | Objectives Cisplatin is an antineoplastic agent, used in the treatment of different types of malignant neoplasms. Side effects such as ototoxicity, nephrotoxicity, and bone marrow toxicity are the main limitations of its clinical use. The aim of the present study was to evaluate the possible effects of hyperbaric oxygen (HBO) therapy as a protective agent in cisplatin-induced ototoxicity in rats. Methods A total of 30 adult Wistar rats (60 ears) were divided into five equal groups. Group 1 is a control group; group 2 is HBO therapy group; group 3 received 15 mg/kg cisplatin intraperitoneally; group 4 received 15 mg/kg cisplatin intraperitoneally and HBO treatment on the same day; group 5 received 15 mg/kg cisplatin intraperitoneally and HBO treatment 72 hours later. The effect of ototoxicity was measured with distortion product otoacoustic emission testing performed on the days 1, 3, and 7. Results Groups 4 and 5 that received HBO treatment after cisplatin had better signal-to-noise ratio (SNR) values compared with group 3 that received only cisplatin (P<0.05). Compared with group 5, group 4 (same day HBO treatment) had better SNR values (P<0.05). Conclusion HBO was found effective for prevention of cisplatin-induced ototoxicity in rats. Our study differs from other studies regarding using a promising treatment, which does not expose subjects to extra stress. |
| first_indexed | 2024-12-20T17:15:42Z |
| format | Article |
| id | doaj.art-9be515580b1441e688f5f6cc03ebea44 |
| institution | Directory Open Access Journal |
| issn | 1976-8710 2005-0720 |
| language | English |
| last_indexed | 2024-12-20T17:15:42Z |
| publishDate | 2019-02-01 |
| publisher | Korean Society of Otorhinolaryngology-Head and Neck Surgery |
| record_format | Article |
| series | Clinical and Experimental Otorhinolaryngology |
| spelling | doaj.art-9be515580b1441e688f5f6cc03ebea442022-12-21T19:32:01ZengKorean Society of Otorhinolaryngology-Head and Neck SurgeryClinical and Experimental Otorhinolaryngology1976-87102005-07202019-02-01121667110.21053/ceo.2017.01704594Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats?H. Bengu Cobanoglu0Erkan Vuralkan1Abdullah Arslan2Bengusu Mirasoglu3A. Savas Toklu4 Department of Otorhinolaryngology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey Department of Otorhinolaryngology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey Department of Underwater and Hyperbaric Medicine, Meram University, Faculty of Medicine, Konya, Turkey Department of Underwater and Hyperbaric Medicine, Istanbul University, Faculty of Medicine, Istanbul, Turkey Department of Underwater and Hyperbaric Medicine, Istanbul University, Faculty of Medicine, Istanbul, TurkeyObjectives Cisplatin is an antineoplastic agent, used in the treatment of different types of malignant neoplasms. Side effects such as ototoxicity, nephrotoxicity, and bone marrow toxicity are the main limitations of its clinical use. The aim of the present study was to evaluate the possible effects of hyperbaric oxygen (HBO) therapy as a protective agent in cisplatin-induced ototoxicity in rats. Methods A total of 30 adult Wistar rats (60 ears) were divided into five equal groups. Group 1 is a control group; group 2 is HBO therapy group; group 3 received 15 mg/kg cisplatin intraperitoneally; group 4 received 15 mg/kg cisplatin intraperitoneally and HBO treatment on the same day; group 5 received 15 mg/kg cisplatin intraperitoneally and HBO treatment 72 hours later. The effect of ototoxicity was measured with distortion product otoacoustic emission testing performed on the days 1, 3, and 7. Results Groups 4 and 5 that received HBO treatment after cisplatin had better signal-to-noise ratio (SNR) values compared with group 3 that received only cisplatin (P<0.05). Compared with group 5, group 4 (same day HBO treatment) had better SNR values (P<0.05). Conclusion HBO was found effective for prevention of cisplatin-induced ototoxicity in rats. Our study differs from other studies regarding using a promising treatment, which does not expose subjects to extra stress.http://www.e-ceo.org/upload/pdf/ceo-2017-01704.pdfHyperbaric OxygenCisplatinOtotoxicityRats |
| spellingShingle | H. Bengu Cobanoglu Erkan Vuralkan Abdullah Arslan Bengusu Mirasoglu A. Savas Toklu Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats? Clinical and Experimental Otorhinolaryngology Hyperbaric Oxygen Cisplatin Ototoxicity Rats |
| title | Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats? |
| title_full | Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats? |
| title_fullStr | Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats? |
| title_full_unstemmed | Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats? |
| title_short | Is Hyperbaric Oxygen Therapy Effective in Cisplatin-Induced Ototoxicity in Rats? |
| title_sort | is hyperbaric oxygen therapy effective in cisplatin induced ototoxicity in rats |
| topic | Hyperbaric Oxygen Cisplatin Ototoxicity Rats |
| url | http://www.e-ceo.org/upload/pdf/ceo-2017-01704.pdf |
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