High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine.

High-Frequency Stimulation of the Rat Entopeduncular Nucleus Does Not Provide Functional or Morphological Neuroprotection from 6-Hydroxydopamine.

Deep brain stimulation (DBS) is the most common neurosurgical treatment for Parkinson's disease (PD). Whereas the globus pallidus interna (GPi) has been less commonly targeted than the subthalamic nucleus (STN), a recent clinical trial suggests that GPi DBS may provide better outcomes for patie...

Full description

Bibliographic Details
Main Authors:	D Luke Fischer, Timothy J Collier, Allyson Cole-Strauss, Susan L Wohlgenant, Jack W Lipton, Kathy Steece-Collier, Fredric P Manfredsson, Christopher J Kemp, Caryl E Sortwell
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2015-01-01
Series:	PLoS ONE
Online Access:	http://europepmc.org/articles/PMC4519335?pdf=render

Similar Items

Stimulation of the rat subthalamic nucleus is neuroprotective following significant nigral dopamine neuron loss
by: A.L. Spieles-Engemann, et al.
Published: (2010-07-01)

Is alpha-synuclein loss-of-function a contributor to parkinsonian pathology? Evidence from non-human primates
by: Timothy J Collier, et al.
Published: (2016-01-01)

Downregulation of striatal CaV1.3 inhibits the escalation of levodopa-induced dyskinesia in male and female parkinsonian rats of advanced age
by: Margaret E. Caulfield, et al.
Published: (2023-06-01)

The BDNF Val66Met polymorphism (rs6265) enhances dopamine neuron graft efficacy and side-effect liability in rs6265 knock-in rats
by: Natosha M. Mercado, et al.
Published: (2021-01-01)

BDNF rs10501087, rs1491850 and rs11030094 polymorphisms associated with delayed progression in early-stage Parkinson's disease
by: D. Luke Fischer, et al.
Published: (2022-11-01)

Sonic Hedgehog Controls the Phenotypic Fate and Therapeutic Efficacy of Grafted Neural Precursor Cells in a Model of Nigrostriatal Neurodegeneration.
by: Lalitha Madhavan, et al.
Published: (2015-01-01)

Mixed representations of choice direction and outcome by GABA/glutamate cotransmitting neurons in the entopeduncular nucleus
by: Julianna Locantore, et al.
Published: (2025-01-01)

Effects of deep brain stimulation (DBS) in the entopeduncular nucleus (EPN) in dystonic dtsz hamsters
by: Anika Lüttig, et al.
Published: (2023-01-01)

Deficient sensorimotor gating induced by selective breeding in rats is improved by entopeduncular nucleus lesions
by: Kerstin Schwabe, et al.
Published: (2009-05-01)

Focal not widespread grafts induce novel dyskinetic behavior in parkinsonian rats
by: Eleonora Maries, et al.
Published: (2006-01-01)

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
by: Katrina L. Paumier, et al.
Published: (2015-10-01)

Subthalamic nucleus but not entopeduncular nucleus deep brain stimulation enhances neurogenesis in the SVZ-olfactory bulb system of Parkinsonian rats
by: Mareike Fauser, et al.
Published: (2024-04-01)

Basal ganglia output (entopeduncular nucleus) coding of contextual kinematics and reward in the freely moving mouse
by: Anil K Verma Rodriguez, et al.
Published: (2025-02-01)

Botulinum toxin A injection into the entopeduncular nucleus improves dynamic locomotory parameters in hemiparkinsonian rats.
by: Adrianna R Tsang, et al.
Published: (2019-01-01)

Quality Over Quantity: Advantages of Using Alpha-Synuclein Preformed Fibril Triggered Synucleinopathy to Model Idiopathic Parkinson’s Disease
by: Megan F. Duffy, et al.
Published: (2018-09-01)

Advancing age and the rs6265 BDNF SNP are permissive to graft-induced dyskinesias in parkinsonian rats
by: Natosha M. Mercado, et al.
Published: (2024-08-01)

Transfer of host-derived alpha synuclein to grafted dopaminergic neurons in rat
by: Jeffrey H. Kordower, et al.
Published: (2011-09-01)

Neuroinflammatory gene expression profiles of reactive glia in the substantia nigra suggest a multidimensional immune response to alpha synuclein inclusions
by: Anna C. Stoll, et al.
Published: (2024-02-01)

Comparison of Neurotoxicity following Repeated Administration of L-Dopa, D-Dopa, and Dopamine to Embryonic Mesencephalic Dopamine Neurons in Cultures Derived from Fisher 344 and Sprague-Dawley Donors
by: T. Alexander, et al.
Published: (1997-05-01)

Repairing the Nervous System: A Special Issue Based on the 12th Annual American Society for Neural Therapy and Repair (ASNTR) Meeting
by: Kathy Steece-Collier Ph.D.
Published: (2006-03-01)

High frequency stimulation of the entopeduncular nucleus sets the cortico-basal ganglia network to a new functional state in the dystonic hamster
by: René Reese, et al.
Published: (2009-09-01)

Interrogating the aged striatum: Robust survival of grafted dopamine neurons in aging rats produces inferior behavioral recovery and evidence of impaired integration
by: Timothy J. Collier, et al.
Published: (2015-05-01)

Valence-encoding in the lateral habenula arises from the entopeduncular region
by: Hao Li, et al.
Published: (2019-03-01)

Chronic deep brain stimulation in the subthalamic nucleus, but not in the entopeduncular nucleus increases neurogenesis in the olfactory bulb, but does not influence hippocampal neurogenesis in a rat model of Parkinson’s disease
by: Mareike Fauser, et al.
Published: (2023-01-01)

Dopaminergic Neuroprotection with Ginkgolide in 6-Hydroxydopamine Rat Parkinson’s Disease Model
by: Alireza Moghadam, et al.
Published: (2019-03-01)

α-Synuclein antisense oligonucleotides as a disease-modifying therapy for Parkinson’s disease
by: Tracy A. Cole, et al.
Published: (2021-03-01)

Reassessment of Caspase Inhibition to Augment Grafted Dopamine Neuron Survival
by: Deanna M. Marchionini, et al.
Published: (2004-04-01)

Effects of subthalamic nucleus lesions and stimulation upon corticostriatal afferents in the 6-hydroxydopamine-lesioned rat.
by: Ruth H Walker, et al.
Published: (2012-01-01)

Alleviation of Methamphetamine Sensitization by Partially Lesioning Dopaminergic Terminals with 6-Hydroxydopamine in Nucleus Accumbens
by: Shu-Chun Chen, et al.
Published: (2021-11-01)

The role of the subthalamic nucleus in L-DOPA induced dyskinesia in 6-hydroxydopamine lesioned rats.
by: Asier Aristieta, et al.
Published: (2012-01-01)

Unraveling neuroprotective and neurodegenerative signals
by: Irving E Vega, et al.
Published: (2016-07-01)

Auricular acupuncture plays a neuroprotective role in 6-hydroxydopamine-induced Parkinson's disease in rats
by: Huong Thi-Mai Nguyen, et al.
Published: (2025-03-01)

Neuroprotective effect of Portulaca oleracea extracts against 6-hydroxydopamine-induced lesion of dopaminergic neurons
by: WALESKA B. MARTINS, et al.
Published: (2016-01-01)

Evaluation of Betaine Neuroprotective Effects on 6-Hydroxydopamine-Induced hemi-Parkinsonism in Male Wistar Rats
by: Behrouz Rahmani, et al.
Published: (2019-09-01)

Beta2-adrenoreceptor agonist clenbuterol produces transient decreases in alpha-synuclein mRNA but no long-term reduction in protein
by: Joseph R. Patterson, et al.
Published: (2022-05-01)

Neuroprotective Effect of Quercetin Nanocrystal in a 6-Hydroxydopamine Model of Parkinson Disease: Biochemical and Behavioral Evidence
by: Fatemeh Ghaffari, et al.
Published: (2018-09-01)

Autophagy and neuroprotection in astrocytes exposed to 6-hydroxydopamine is negatively regulated by NQO2: relevance to Parkinson’s disease
by: Elzbieta Janda, et al.
Published: (2023-12-01)

Sea Anemone Kunitz-Type Peptides Demonstrate Neuroprotective Activity in the 6-Hydroxydopamine Induced Neurotoxicity Model
by: Oksana Sintsova, et al.
Published: (2021-03-01)

Neuroprotective Effect of Oral Administration of Creatine against 6-Hydroxydopamine Toxicity in Experimental Model of Parkinson's Disease
by: Reza Sedaghat, et al.
Published: (2015-07-01)

Neuroprotective Activity of Some Marine Fungal Metabolites in the 6-Hydroxydopamin- and Paraquat-Induced Parkinson’s Disease Models
by: Ekaterina A. Yurchenko, et al.
Published: (2018-11-01)