Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary Disease

Currently, chronic obstructive pulmonary disease (COPD) patients and their physicians face a number of significant clinical challenges, one of which is the high degree of uncertainty related to chronic bronchial infection (CBI). By reviewing the current literature, several challenges can be identifi...

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Main Authors: José Luis Lopez-Campos, Marc Miravitlles, David de la Rosa Carrillo, Rafael Cantón, Juan Jose Soler-Cataluña, Miguel Angel Martinez-Garcia
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Journal of Clinical Medicine
Subjects:
Online Access:https://www.mdpi.com/2077-0383/9/6/1639
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author José Luis Lopez-Campos
Marc Miravitlles
David de la Rosa Carrillo
Rafael Cantón
Juan Jose Soler-Cataluña
Miguel Angel Martinez-Garcia
author_facet José Luis Lopez-Campos
Marc Miravitlles
David de la Rosa Carrillo
Rafael Cantón
Juan Jose Soler-Cataluña
Miguel Angel Martinez-Garcia
author_sort José Luis Lopez-Campos
collection DOAJ
description Currently, chronic obstructive pulmonary disease (COPD) patients and their physicians face a number of significant clinical challenges, one of which is the high degree of uncertainty related to chronic bronchial infection (CBI). By reviewing the current literature, several challenges can be identified, which should be considered as goals for research. One of these is to establish the bases for identifying the biological and clinical implications of the presence of potentially pathogenic microorganisms in the airways that should be more clearly elucidated according to the COPD phenotype. Another urgent area of research is the role of long-term preventive antibiotics. Clinical trials need to be carried out with inhaled antibiotic therapy to help clarify the profile of those antibiotics. The role of inhaled corticosteroids in patients with COPD and CBI needs to be studied to instruct the clinical management of these patients. Finally, it should be explored and confirmed whether a suitable antimicrobial treatment during exacerbations may contribute to breaking the vicious circle of CBI in COPD. The present review addresses the current state of the art in these areas to provide evidence which will enable us to progressively plan better healthcare for these patients.
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spelling doaj.art-9be6773d4763478c8520d2611cc08c2a2023-11-20T02:06:10ZengMDPI AGJournal of Clinical Medicine2077-03832020-05-0196163910.3390/jcm9061639Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary DiseaseJosé Luis Lopez-Campos0Marc Miravitlles1David de la Rosa Carrillo2Rafael Cantón3Juan Jose Soler-Cataluña4Miguel Angel Martinez-Garcia5Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Universidad de Sevilla, 41013 Seville, SpainCIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, SpainPneumology Department, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, SpainServicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainPneumology, Hospital Arnau de Villanova-Lliria, 46015 Valencia, SpainCIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, SpainCurrently, chronic obstructive pulmonary disease (COPD) patients and their physicians face a number of significant clinical challenges, one of which is the high degree of uncertainty related to chronic bronchial infection (CBI). By reviewing the current literature, several challenges can be identified, which should be considered as goals for research. One of these is to establish the bases for identifying the biological and clinical implications of the presence of potentially pathogenic microorganisms in the airways that should be more clearly elucidated according to the COPD phenotype. Another urgent area of research is the role of long-term preventive antibiotics. Clinical trials need to be carried out with inhaled antibiotic therapy to help clarify the profile of those antibiotics. The role of inhaled corticosteroids in patients with COPD and CBI needs to be studied to instruct the clinical management of these patients. Finally, it should be explored and confirmed whether a suitable antimicrobial treatment during exacerbations may contribute to breaking the vicious circle of CBI in COPD. The present review addresses the current state of the art in these areas to provide evidence which will enable us to progressively plan better healthcare for these patients.https://www.mdpi.com/2077-0383/9/6/1639COPDpotentially pathogenic microorganismchronic bronchial infection
spellingShingle José Luis Lopez-Campos
Marc Miravitlles
David de la Rosa Carrillo
Rafael Cantón
Juan Jose Soler-Cataluña
Miguel Angel Martinez-Garcia
Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary Disease
Journal of Clinical Medicine
COPD
potentially pathogenic microorganism
chronic bronchial infection
title Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary Disease
title_full Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary Disease
title_fullStr Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary Disease
title_full_unstemmed Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary Disease
title_short Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary Disease
title_sort current challenges in chronic bronchial infection in patients with chronic obstructive pulmonary disease
topic COPD
potentially pathogenic microorganism
chronic bronchial infection
url https://www.mdpi.com/2077-0383/9/6/1639
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