Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary Disease
Currently, chronic obstructive pulmonary disease (COPD) patients and their physicians face a number of significant clinical challenges, one of which is the high degree of uncertainty related to chronic bronchial infection (CBI). By reviewing the current literature, several challenges can be identifi...
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MDPI AG
2020-05-01
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Series: | Journal of Clinical Medicine |
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Online Access: | https://www.mdpi.com/2077-0383/9/6/1639 |
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author | José Luis Lopez-Campos Marc Miravitlles David de la Rosa Carrillo Rafael Cantón Juan Jose Soler-Cataluña Miguel Angel Martinez-Garcia |
author_facet | José Luis Lopez-Campos Marc Miravitlles David de la Rosa Carrillo Rafael Cantón Juan Jose Soler-Cataluña Miguel Angel Martinez-Garcia |
author_sort | José Luis Lopez-Campos |
collection | DOAJ |
description | Currently, chronic obstructive pulmonary disease (COPD) patients and their physicians face a number of significant clinical challenges, one of which is the high degree of uncertainty related to chronic bronchial infection (CBI). By reviewing the current literature, several challenges can be identified, which should be considered as goals for research. One of these is to establish the bases for identifying the biological and clinical implications of the presence of potentially pathogenic microorganisms in the airways that should be more clearly elucidated according to the COPD phenotype. Another urgent area of research is the role of long-term preventive antibiotics. Clinical trials need to be carried out with inhaled antibiotic therapy to help clarify the profile of those antibiotics. The role of inhaled corticosteroids in patients with COPD and CBI needs to be studied to instruct the clinical management of these patients. Finally, it should be explored and confirmed whether a suitable antimicrobial treatment during exacerbations may contribute to breaking the vicious circle of CBI in COPD. The present review addresses the current state of the art in these areas to provide evidence which will enable us to progressively plan better healthcare for these patients. |
first_indexed | 2024-03-10T19:31:42Z |
format | Article |
id | doaj.art-9be6773d4763478c8520d2611cc08c2a |
institution | Directory Open Access Journal |
issn | 2077-0383 |
language | English |
last_indexed | 2024-03-10T19:31:42Z |
publishDate | 2020-05-01 |
publisher | MDPI AG |
record_format | Article |
series | Journal of Clinical Medicine |
spelling | doaj.art-9be6773d4763478c8520d2611cc08c2a2023-11-20T02:06:10ZengMDPI AGJournal of Clinical Medicine2077-03832020-05-0196163910.3390/jcm9061639Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary DiseaseJosé Luis Lopez-Campos0Marc Miravitlles1David de la Rosa Carrillo2Rafael Cantón3Juan Jose Soler-Cataluña4Miguel Angel Martinez-Garcia5Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/Universidad de Sevilla, 41013 Seville, SpainCIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, SpainPneumology Department, Hospital de la Santa Creu i Sant Pau, 08041 Barcelona, SpainServicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS), 28034 Madrid, SpainPneumology, Hospital Arnau de Villanova-Lliria, 46015 Valencia, SpainCIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, SpainCurrently, chronic obstructive pulmonary disease (COPD) patients and their physicians face a number of significant clinical challenges, one of which is the high degree of uncertainty related to chronic bronchial infection (CBI). By reviewing the current literature, several challenges can be identified, which should be considered as goals for research. One of these is to establish the bases for identifying the biological and clinical implications of the presence of potentially pathogenic microorganisms in the airways that should be more clearly elucidated according to the COPD phenotype. Another urgent area of research is the role of long-term preventive antibiotics. Clinical trials need to be carried out with inhaled antibiotic therapy to help clarify the profile of those antibiotics. The role of inhaled corticosteroids in patients with COPD and CBI needs to be studied to instruct the clinical management of these patients. Finally, it should be explored and confirmed whether a suitable antimicrobial treatment during exacerbations may contribute to breaking the vicious circle of CBI in COPD. The present review addresses the current state of the art in these areas to provide evidence which will enable us to progressively plan better healthcare for these patients.https://www.mdpi.com/2077-0383/9/6/1639COPDpotentially pathogenic microorganismchronic bronchial infection |
spellingShingle | José Luis Lopez-Campos Marc Miravitlles David de la Rosa Carrillo Rafael Cantón Juan Jose Soler-Cataluña Miguel Angel Martinez-Garcia Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary Disease Journal of Clinical Medicine COPD potentially pathogenic microorganism chronic bronchial infection |
title | Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary Disease |
title_full | Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary Disease |
title_fullStr | Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary Disease |
title_full_unstemmed | Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary Disease |
title_short | Current Challenges in Chronic Bronchial Infection in Patients with Chronic Obstructive Pulmonary Disease |
title_sort | current challenges in chronic bronchial infection in patients with chronic obstructive pulmonary disease |
topic | COPD potentially pathogenic microorganism chronic bronchial infection |
url | https://www.mdpi.com/2077-0383/9/6/1639 |
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