Increased efficacy of biologics following inhibition of autophagy in A549 lung cancer cells in bimodal treatment of doxorubicin and SAR405-loaded chitosan nanoparticles

Increased efficacy of biologics following inhibition of autophagy in A549 lung cancer cells in bimodal treatment of doxorubicin and SAR405-loaded chitosan nanoparticles

Conventional anti-cancer drugs, including doxorubicin, are associated with high toxicity and non-specific distribution in the body which results in a cascade of side effects. Cancer cells can utilize autophagy to promote tolerance to the stress induced by anti-cancer agents; this may be the major ca...

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Bibliographic Details
Main Authors: Mohammed Numan Alamassi, Suet Lin Chia, Che Azurahanim Che Abdullah, Mas Jaffri Masarudin
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:OpenNano
Subjects:
Doxorubicin
Sar405
Chitosan nanoparticles
Nanomedicine
Nanotechnology
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S235295202300021X

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