Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male Rats
Diet-induced obesity models are widely used to investigate dietary interventions for treating obesity. This study was aimed to test whether a dietary intervention based on a calorie-restricted cafeteria diet (CAF-R) and a polyphenolic compound (Oleuropein, OLE) supplementation modified sucrose intak...
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MDPI AG
2021-12-01
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| Online Access: | https://www.mdpi.com/2072-6643/13/12/4474 |
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| author | Alex Subias-Gusils Adam Álvarez-Monell Noemí Boqué Antoni Caimari Josep M. Del Bas Roger Mariné-Casadó Montserrat Solanas Rosa M. Escorihuela |
| author_facet | Alex Subias-Gusils Adam Álvarez-Monell Noemí Boqué Antoni Caimari Josep M. Del Bas Roger Mariné-Casadó Montserrat Solanas Rosa M. Escorihuela |
| author_sort | Alex Subias-Gusils |
| collection | DOAJ |
| description | Diet-induced obesity models are widely used to investigate dietary interventions for treating obesity. This study was aimed to test whether a dietary intervention based on a calorie-restricted cafeteria diet (CAF-R) and a polyphenolic compound (Oleuropein, OLE) supplementation modified sucrose intake, preference, and taste reactivity in cafeteria diet (CAF)-induced obese rats. CAF diet consists of high-energy, highly palatable human foods. Male rats fed standard chow (STD) or CAF diet were compared with obese rats fed CAF-R diet, alone or supplemented with an olive tree leaves extract (25 mg/kg*day) containing a 20.1% of OLE (CAF-RO). Biometric, food consumption, and serum parameters were measured. CAF diet increased body weight, food and energy consumption and obesity-associated metabolic parameters. CAF-R and CAF-RO diets significantly attenuated body weight gain and BMI, diminished food and energy intake and improved biochemical parameters such as triacylglycerides and insulin resistance which did not differ between CAF-RO and STD groups. The three cafeteria groups diminished sucrose intake and preference compared to STD group. CAF-RO also diminished the hedonic responses for the high sucrose concentrations compared with the other groups. These results indicate that CAF-R diet may be an efficient strategy to restore obesity-associated alterations, whilst OLE supplementation seems to have an additional beneficial effect on sweet taste function. |
| first_indexed | 2024-03-10T03:23:35Z |
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| institution | Directory Open Access Journal |
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| last_indexed | 2024-03-10T03:23:35Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
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| series | Nutrients |
| spelling | doaj.art-9be9e51fed1d4de584f7e52c693bf95f2023-11-23T09:58:13ZengMDPI AGNutrients2072-66432021-12-011312447410.3390/nu13124474Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male RatsAlex Subias-Gusils0Adam Álvarez-Monell1Noemí Boqué2Antoni Caimari3Josep M. Del Bas4Roger Mariné-Casadó5Montserrat Solanas6Rosa M. Escorihuela7Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, SpainInstitut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, SpainEurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, SpainEurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, SpainEurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, SpainEurecat, Centre Tecnològic de Catalunya, Technological Unit of Nutrition and Health, 43204 Reus, SpainInstitut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, SpainInstitut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, SpainDiet-induced obesity models are widely used to investigate dietary interventions for treating obesity. This study was aimed to test whether a dietary intervention based on a calorie-restricted cafeteria diet (CAF-R) and a polyphenolic compound (Oleuropein, OLE) supplementation modified sucrose intake, preference, and taste reactivity in cafeteria diet (CAF)-induced obese rats. CAF diet consists of high-energy, highly palatable human foods. Male rats fed standard chow (STD) or CAF diet were compared with obese rats fed CAF-R diet, alone or supplemented with an olive tree leaves extract (25 mg/kg*day) containing a 20.1% of OLE (CAF-RO). Biometric, food consumption, and serum parameters were measured. CAF diet increased body weight, food and energy consumption and obesity-associated metabolic parameters. CAF-R and CAF-RO diets significantly attenuated body weight gain and BMI, diminished food and energy intake and improved biochemical parameters such as triacylglycerides and insulin resistance which did not differ between CAF-RO and STD groups. The three cafeteria groups diminished sucrose intake and preference compared to STD group. CAF-RO also diminished the hedonic responses for the high sucrose concentrations compared with the other groups. These results indicate that CAF-R diet may be an efficient strategy to restore obesity-associated alterations, whilst OLE supplementation seems to have an additional beneficial effect on sweet taste function.https://www.mdpi.com/2072-6643/13/12/4474diet-induced obesityenergy restrictionfood intakehedonic responseleptinpolyphenols |
| spellingShingle | Alex Subias-Gusils Adam Álvarez-Monell Noemí Boqué Antoni Caimari Josep M. Del Bas Roger Mariné-Casadó Montserrat Solanas Rosa M. Escorihuela Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male Rats Nutrients diet-induced obesity energy restriction food intake hedonic response leptin polyphenols |
| title | Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male Rats |
| title_full | Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male Rats |
| title_fullStr | Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male Rats |
| title_full_unstemmed | Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male Rats |
| title_short | Behavioral and Metabolic Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation in Obese Male Rats |
| title_sort | behavioral and metabolic effects of a calorie restricted cafeteria diet and oleuropein supplementation in obese male rats |
| topic | diet-induced obesity energy restriction food intake hedonic response leptin polyphenols |
| url | https://www.mdpi.com/2072-6643/13/12/4474 |
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