Temporal rank of clinical characteristics and prognosis of anti‐N‐methyl‐d‐aspartate receptor encephalitis
Abstract Objectives Early recognition and intervention of patients with the anti‐N‐methyl‐d‐aspartate receptor (NMDAR) encephalitis are important to achieve a better prognosis. The study aims to summarize the real‐world perspectives of anti‐NMDAR encephalitis patients in China via electronic medical...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.2277 |
| _version_ | 1797754667702157312 |
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| author | Runnan Yang Fenfen Ge Jingwen Jiang Yue Wang Mengtong Wan Wei Zhang |
| author_facet | Runnan Yang Fenfen Ge Jingwen Jiang Yue Wang Mengtong Wan Wei Zhang |
| author_sort | Runnan Yang |
| collection | DOAJ |
| description | Abstract Objectives Early recognition and intervention of patients with the anti‐N‐methyl‐d‐aspartate receptor (NMDAR) encephalitis are important to achieve a better prognosis. The study aims to summarize the real‐world perspectives of anti‐NMDAR encephalitis patients in China via electronic medical records (EMRs). Methods Using EMRs of patients from 2013 to 2019 from West China Hospital in China, a retrospective research was conducted to demonstrate the temporary rank of clinical characteristics and disease prognosis of anti‐NMDAR encephalitis. The modified Rankin Scale (mRS) scores were used to divide the anti‐NMDAR‐encephalitis into two groups (poor prognosis vs. good prognosis). Chi‐square test and logistic regression were used to analyze factors associated with prognosis. Results Here, 78 patients were included. The most common clinical characteristics are cognitive dysfunction (86.0%) and thought disorder (86.0%). Cognitive dysfunction, thought disorder, and seizures tended to appear soon after prodrome symptoms. Logistics analysis results showed that cognitive dysfunction (OR = 4.48, 95% CI = 1.09–18.47), the score of (GCS ≤ 8) (OR = 4.52, 95% CI = 1.18–17.32), positive antibodies in serum (OR = 4.89, 95% CI = 1.19–20.13) and delay immunotherapy (OR = 4.76, 95% CI = 1.79–12.60) were risk factors of poor clinical outcomes. Conclusions There are two peaks in the development of autoimmune encephalitis (AE). The first peak is cognitive dysfunction, and the second peak is autonomic dysfunction. Cognitive dysfunction and GCS score ≤8 at admission, antibodies positive in serum, and delay immunotherapy were risk factors for a poor prognosis at discharge. |
| first_indexed | 2024-03-12T17:35:46Z |
| format | Article |
| id | doaj.art-9bea1fdbc7ae42f2a24f4c759bbf294d |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-12T17:35:46Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-9bea1fdbc7ae42f2a24f4c759bbf294d2023-08-04T10:56:25ZengWileyBrain and Behavior2162-32792021-08-01118n/an/a10.1002/brb3.2277Temporal rank of clinical characteristics and prognosis of anti‐N‐methyl‐d‐aspartate receptor encephalitisRunnan Yang0Fenfen Ge1Jingwen Jiang2Yue Wang3Mengtong Wan4Wei Zhang5Mental Health Center West China Hospital Sichuan University Chengdu Sichuan ChinaMental Health Center West China Hospital Sichuan University Chengdu Sichuan ChinaWest China Biomedical Big Data Center West China Hospital Sichuan University Chengdu Sichuan ChinaMental Health Center West China Hospital Sichuan University Chengdu Sichuan ChinaWuyuzhuang Honors College Sichuan University Chengdu Sichuan ChinaMental Health Center West China Hospital Sichuan University Chengdu Sichuan ChinaAbstract Objectives Early recognition and intervention of patients with the anti‐N‐methyl‐d‐aspartate receptor (NMDAR) encephalitis are important to achieve a better prognosis. The study aims to summarize the real‐world perspectives of anti‐NMDAR encephalitis patients in China via electronic medical records (EMRs). Methods Using EMRs of patients from 2013 to 2019 from West China Hospital in China, a retrospective research was conducted to demonstrate the temporary rank of clinical characteristics and disease prognosis of anti‐NMDAR encephalitis. The modified Rankin Scale (mRS) scores were used to divide the anti‐NMDAR‐encephalitis into two groups (poor prognosis vs. good prognosis). Chi‐square test and logistic regression were used to analyze factors associated with prognosis. Results Here, 78 patients were included. The most common clinical characteristics are cognitive dysfunction (86.0%) and thought disorder (86.0%). Cognitive dysfunction, thought disorder, and seizures tended to appear soon after prodrome symptoms. Logistics analysis results showed that cognitive dysfunction (OR = 4.48, 95% CI = 1.09–18.47), the score of (GCS ≤ 8) (OR = 4.52, 95% CI = 1.18–17.32), positive antibodies in serum (OR = 4.89, 95% CI = 1.19–20.13) and delay immunotherapy (OR = 4.76, 95% CI = 1.79–12.60) were risk factors of poor clinical outcomes. Conclusions There are two peaks in the development of autoimmune encephalitis (AE). The first peak is cognitive dysfunction, and the second peak is autonomic dysfunction. Cognitive dysfunction and GCS score ≤8 at admission, antibodies positive in serum, and delay immunotherapy were risk factors for a poor prognosis at discharge.https://doi.org/10.1002/brb3.2277anti‐N‐methyl‐d‐aspartate receptor encephalitisdiagnosiselectronic medical recordsprognosis |
| spellingShingle | Runnan Yang Fenfen Ge Jingwen Jiang Yue Wang Mengtong Wan Wei Zhang Temporal rank of clinical characteristics and prognosis of anti‐N‐methyl‐d‐aspartate receptor encephalitis Brain and Behavior anti‐N‐methyl‐d‐aspartate receptor encephalitis diagnosis electronic medical records prognosis |
| title | Temporal rank of clinical characteristics and prognosis of anti‐N‐methyl‐d‐aspartate receptor encephalitis |
| title_full | Temporal rank of clinical characteristics and prognosis of anti‐N‐methyl‐d‐aspartate receptor encephalitis |
| title_fullStr | Temporal rank of clinical characteristics and prognosis of anti‐N‐methyl‐d‐aspartate receptor encephalitis |
| title_full_unstemmed | Temporal rank of clinical characteristics and prognosis of anti‐N‐methyl‐d‐aspartate receptor encephalitis |
| title_short | Temporal rank of clinical characteristics and prognosis of anti‐N‐methyl‐d‐aspartate receptor encephalitis |
| title_sort | temporal rank of clinical characteristics and prognosis of anti n methyl d aspartate receptor encephalitis |
| topic | anti‐N‐methyl‐d‐aspartate receptor encephalitis diagnosis electronic medical records prognosis |
| url | https://doi.org/10.1002/brb3.2277 |
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