The Predicted Value of Kidney Injury Molecule-1 (KIM-1) in Healthy People
Shanshan Peng,1 Na Liu,1 Kai Wei,1 Gang Li,2 Zheng Zou,3 Tao Liu,3 Meifang Shi,3 Yuan Lv,1 Yong Lin1 1Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Shanghai Baoshan Renhe Hospital, Shanghai, People’s Republic of China; 3Youyi Road Commu...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2022-04-01
|
| Series: | International Journal of General Medicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/the-predicted-value-of-kidney-injury-molecule-1-kim-1-in-healthy-peopl-peer-reviewed-fulltext-article-IJGM |
| _version_ | 1811288920786206720 |
|---|---|
| author | Peng S Liu N Wei K Li G Zou Z Liu T Shi M Lv Y Lin Y |
| author_facet | Peng S Liu N Wei K Li G Zou Z Liu T Shi M Lv Y Lin Y |
| author_sort | Peng S |
| collection | DOAJ |
| description | Shanshan Peng,1 Na Liu,1 Kai Wei,1 Gang Li,2 Zheng Zou,3 Tao Liu,3 Meifang Shi,3 Yuan Lv,1 Yong Lin1 1Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Shanghai Baoshan Renhe Hospital, Shanghai, People’s Republic of China; 3Youyi Road Community Health Service Centre for Baoshan District, Shanghai, People’s Republic of ChinaCorrespondence: Yong Lin, Department of Laboratory Medicine, Huashan Hospital, Fudan University, No. 12 the Middle of Urumqi Road, Shanghai, People’s Republic of China, Tel +86 13916553198, Email linyong7007@163.comPurpose: Recent studies have focused on whether kidney injury molecule-1 (KIM-1) might serve as a marker of acute kidney tubular injury. Our study analyzed the levels of KIM-1 in the healthy population of different ages to explore the correlation between KIM-1 and age. Moreover, we constructed a model to predict kidney age.Methods: A cross-sectional study was conducted by Huashan Hospital, Shanghai, China, between April 2020 and December 2020. KIM-1 and other kidney biomarkers were measured in 176 healthy individuals ranging from 26 to 91 years old. Statistical correlated analyses for urinary KIM-1, creatinine (uCREA), potassium (K), sodium (Na) and chlorine (Cl), plasmic renin, angiotensin-2 (AngII) and aldosterone (ALD), and serum microalbuminuria (MALB), β 2-microglobulin (B2MG), cystatin C (CYSC), urea nitrogen (BUN), creatinine (CREA), and glucose (GLU) were performed to assess the correlation between age and kidney biomarkers. All variables were selected as independent variables for the prediction of age by multiple linear regression.Results: KIM-1 positively correlated with age in kidney healthy people (r = 0.41, p < 0.05), whether among females (r = 0.51, p < 0.05) or males (r = 0.27, p < 0.05). It was much related to K (r = 0.34), B2MG (r = 0.28), and CL (r = 0.23). The predicted model was constructed with eGFR, Cl, ALD, CYSC, KIM-1, BUN, GLU and AngII, reaching an adjusted R2 of 69.5% and a standard error of the estimated 7.84 years.Conclusion: The level of urinary KIM-1 increases with age in healthy people. The model constructed by KIM-1 and the other 7 biomarkers can predict kidney age in healthy people.Keywords: aging, kidney biomarkers, KIM-1, healthy |
| first_indexed | 2024-04-13T03:46:00Z |
| format | Article |
| id | doaj.art-9bea3c319951419eb62008ff0359b9a7 |
| institution | Directory Open Access Journal |
| issn | 1178-7074 |
| language | English |
| last_indexed | 2024-04-13T03:46:00Z |
| publishDate | 2022-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of General Medicine |
| spelling | doaj.art-9bea3c319951419eb62008ff0359b9a72022-12-22T03:04:01ZengDove Medical PressInternational Journal of General Medicine1178-70742022-04-01Volume 154495450374903The Predicted Value of Kidney Injury Molecule-1 (KIM-1) in Healthy PeoplePeng SLiu NWei KLi GZou ZLiu TShi MLv YLin YShanshan Peng,1 Na Liu,1 Kai Wei,1 Gang Li,2 Zheng Zou,3 Tao Liu,3 Meifang Shi,3 Yuan Lv,1 Yong Lin1 1Department of Laboratory Medicine, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 2Shanghai Baoshan Renhe Hospital, Shanghai, People’s Republic of China; 3Youyi Road Community Health Service Centre for Baoshan District, Shanghai, People’s Republic of ChinaCorrespondence: Yong Lin, Department of Laboratory Medicine, Huashan Hospital, Fudan University, No. 12 the Middle of Urumqi Road, Shanghai, People’s Republic of China, Tel +86 13916553198, Email linyong7007@163.comPurpose: Recent studies have focused on whether kidney injury molecule-1 (KIM-1) might serve as a marker of acute kidney tubular injury. Our study analyzed the levels of KIM-1 in the healthy population of different ages to explore the correlation between KIM-1 and age. Moreover, we constructed a model to predict kidney age.Methods: A cross-sectional study was conducted by Huashan Hospital, Shanghai, China, between April 2020 and December 2020. KIM-1 and other kidney biomarkers were measured in 176 healthy individuals ranging from 26 to 91 years old. Statistical correlated analyses for urinary KIM-1, creatinine (uCREA), potassium (K), sodium (Na) and chlorine (Cl), plasmic renin, angiotensin-2 (AngII) and aldosterone (ALD), and serum microalbuminuria (MALB), β 2-microglobulin (B2MG), cystatin C (CYSC), urea nitrogen (BUN), creatinine (CREA), and glucose (GLU) were performed to assess the correlation between age and kidney biomarkers. All variables were selected as independent variables for the prediction of age by multiple linear regression.Results: KIM-1 positively correlated with age in kidney healthy people (r = 0.41, p < 0.05), whether among females (r = 0.51, p < 0.05) or males (r = 0.27, p < 0.05). It was much related to K (r = 0.34), B2MG (r = 0.28), and CL (r = 0.23). The predicted model was constructed with eGFR, Cl, ALD, CYSC, KIM-1, BUN, GLU and AngII, reaching an adjusted R2 of 69.5% and a standard error of the estimated 7.84 years.Conclusion: The level of urinary KIM-1 increases with age in healthy people. The model constructed by KIM-1 and the other 7 biomarkers can predict kidney age in healthy people.Keywords: aging, kidney biomarkers, KIM-1, healthyhttps://www.dovepress.com/the-predicted-value-of-kidney-injury-molecule-1-kim-1-in-healthy-peopl-peer-reviewed-fulltext-article-IJGMagingkidney biomarkerskim-1healthy |
| spellingShingle | Peng S Liu N Wei K Li G Zou Z Liu T Shi M Lv Y Lin Y The Predicted Value of Kidney Injury Molecule-1 (KIM-1) in Healthy People International Journal of General Medicine aging kidney biomarkers kim-1 healthy |
| title | The Predicted Value of Kidney Injury Molecule-1 (KIM-1) in Healthy People |
| title_full | The Predicted Value of Kidney Injury Molecule-1 (KIM-1) in Healthy People |
| title_fullStr | The Predicted Value of Kidney Injury Molecule-1 (KIM-1) in Healthy People |
| title_full_unstemmed | The Predicted Value of Kidney Injury Molecule-1 (KIM-1) in Healthy People |
| title_short | The Predicted Value of Kidney Injury Molecule-1 (KIM-1) in Healthy People |
| title_sort | predicted value of kidney injury molecule 1 kim 1 in healthy people |
| topic | aging kidney biomarkers kim-1 healthy |
| url | https://www.dovepress.com/the-predicted-value-of-kidney-injury-molecule-1-kim-1-in-healthy-peopl-peer-reviewed-fulltext-article-IJGM |
| work_keys_str_mv | AT pengs thepredictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT liun thepredictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT weik thepredictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT lig thepredictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT zouz thepredictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT liut thepredictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT shim thepredictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT lvy thepredictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT liny thepredictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT pengs predictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT liun predictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT weik predictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT lig predictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT zouz predictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT liut predictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT shim predictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT lvy predictedvalueofkidneyinjurymolecule1kim1inhealthypeople AT liny predictedvalueofkidneyinjurymolecule1kim1inhealthypeople |