Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral Hemorrhage
(1) Background: As elements of the standard admission blood panel, lactate and glucose represent potential biomarkers for outcome prediction. In patients with intracranial hemorrhage (ICH), data on the predictive value of these blood values is exceedingly sparse. (2) Methods: Between 2014 and August...
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MDPI AG
2021-05-01
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| Online Access: | https://www.mdpi.com/2076-3425/11/5/633 |
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| author | Felix Lehmann Lorena M. Schenk Matthias Schneider Joshua D. Bernstock Christian Bode Valeri Borger Florian Gessler Erdem Güresir Alexis Hadjiathanasiou Motaz Hamed Marcus Müller Christian Putensen Julian Zimmermann Hartmut Vatter Patrick Schuss |
| author_facet | Felix Lehmann Lorena M. Schenk Matthias Schneider Joshua D. Bernstock Christian Bode Valeri Borger Florian Gessler Erdem Güresir Alexis Hadjiathanasiou Motaz Hamed Marcus Müller Christian Putensen Julian Zimmermann Hartmut Vatter Patrick Schuss |
| author_sort | Felix Lehmann |
| collection | DOAJ |
| description | (1) Background: As elements of the standard admission blood panel, lactate and glucose represent potential biomarkers for outcome prediction. In patients with intracranial hemorrhage (ICH), data on the predictive value of these blood values is exceedingly sparse. (2) Methods: Between 2014 and August 2020, all patients with deep-seated ICH referred to the neurovascular center at the authors’ institution were included in the subsequent study. Serum levels of lactate and glucose at the time of admission were compared with mortality at 90 days. In addition, a multivariate analysis was performed in order to identify independent admission predictors for 90-day mortality. (3) Results: Among the 102 patients with deep-seated ICH, elevated lactate and glucose levels on admission were significantly associated with increased mortality at 90 days. Multivariate logistic regression analysis identified “ICH score ≥3” (<i>p</i> = 0.004) along with “admission hyperlactatemia” (<i>p</i> = 0.025) and “admission hyperglycemia” (<i>p</i> = 0.029) as independent and significant predictors of 90-day mortality in patients with deep-seated ICH. (4) Conclusions: Initially elevated lactate and glucose levels after spontaneous intracerebral hemorrhage are associated with poor outcome, suggesting a potential application for future prognostic models when considered in conjunction with other parameters. |
| first_indexed | 2024-03-10T11:25:01Z |
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| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-10T11:25:01Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-9beb1c0c6d904fc2a0ffe84ac90752712023-11-21T19:45:03ZengMDPI AGBrain Sciences2076-34252021-05-0111563310.3390/brainsci11050633Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral HemorrhageFelix Lehmann0Lorena M. Schenk1Matthias Schneider2Joshua D. Bernstock3Christian Bode4Valeri Borger5Florian Gessler6Erdem Güresir7Alexis Hadjiathanasiou8Motaz Hamed9Marcus Müller10Christian Putensen11Julian Zimmermann12Hartmut Vatter13Patrick Schuss14Department of Anesthesiology and Intensive Care, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USADepartment of Anesthesiology and Intensive Care, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Neurosurgery, University Hospital Rostock, 18057 Rostock, GermanyDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Neurology, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Anesthesiology and Intensive Care, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Neurology, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, GermanyDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany(1) Background: As elements of the standard admission blood panel, lactate and glucose represent potential biomarkers for outcome prediction. In patients with intracranial hemorrhage (ICH), data on the predictive value of these blood values is exceedingly sparse. (2) Methods: Between 2014 and August 2020, all patients with deep-seated ICH referred to the neurovascular center at the authors’ institution were included in the subsequent study. Serum levels of lactate and glucose at the time of admission were compared with mortality at 90 days. In addition, a multivariate analysis was performed in order to identify independent admission predictors for 90-day mortality. (3) Results: Among the 102 patients with deep-seated ICH, elevated lactate and glucose levels on admission were significantly associated with increased mortality at 90 days. Multivariate logistic regression analysis identified “ICH score ≥3” (<i>p</i> = 0.004) along with “admission hyperlactatemia” (<i>p</i> = 0.025) and “admission hyperglycemia” (<i>p</i> = 0.029) as independent and significant predictors of 90-day mortality in patients with deep-seated ICH. (4) Conclusions: Initially elevated lactate and glucose levels after spontaneous intracerebral hemorrhage are associated with poor outcome, suggesting a potential application for future prognostic models when considered in conjunction with other parameters.https://www.mdpi.com/2076-3425/11/5/633intracerebral hemorrhagelactateglucosemortality |
| spellingShingle | Felix Lehmann Lorena M. Schenk Matthias Schneider Joshua D. Bernstock Christian Bode Valeri Borger Florian Gessler Erdem Güresir Alexis Hadjiathanasiou Motaz Hamed Marcus Müller Christian Putensen Julian Zimmermann Hartmut Vatter Patrick Schuss Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral Hemorrhage Brain Sciences intracerebral hemorrhage lactate glucose mortality |
| title | Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral Hemorrhage |
| title_full | Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral Hemorrhage |
| title_fullStr | Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral Hemorrhage |
| title_full_unstemmed | Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral Hemorrhage |
| title_short | Predictive Relevance of Baseline Lactate and Glucose Levels in Patients with Spontaneous Deep-Seated Intracerebral Hemorrhage |
| title_sort | predictive relevance of baseline lactate and glucose levels in patients with spontaneous deep seated intracerebral hemorrhage |
| topic | intracerebral hemorrhage lactate glucose mortality |
| url | https://www.mdpi.com/2076-3425/11/5/633 |
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