Extracellular vesicle profiling and their use as potential disease specific biomarker
Cell derived vesicles; in particular extracellular vesicles (EVs) such as microparticles (MPs) and microvesicles (MVs) besides exosomes are raising more and more attention as a novel and unique approach to detect diseases. It has recently become apparent, that disease specific MP signatures or profi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-09-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00413/full |
| _version_ | 1818501787442741248 |
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| author | Henrike eJulich Arnulf eWillms Veronika eLukacs-Kornek Miroslaw eKornek Miroslaw eKornek |
| author_facet | Henrike eJulich Arnulf eWillms Veronika eLukacs-Kornek Miroslaw eKornek Miroslaw eKornek |
| author_sort | Henrike eJulich |
| collection | DOAJ |
| description | Cell derived vesicles; in particular extracellular vesicles (EVs) such as microparticles (MPs) and microvesicles (MVs) besides exosomes are raising more and more attention as a novel and unique approach to detect diseases. It has recently become apparent, that disease specific MP signatures or profiles might be beneficial to differentiate chronic liver diseases such as non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC), to monitor their progression or possibly to assess treatment outcome. Therefore EVs might serve as a novel inexpensive and minimally invasive method to screen risk patients for the outbreak of a disease even before the initial symptoms, to follow up treatment complications and disease relapse. The purpose of the current review is to summarize already published EVs signatures for a limited number of exemplary diseases and to discuss their possible impact. Additionally, it will be discussed if the combination of EV profiling and miRNA profiling could be a future joint tool for the purpose of detecting cancer and from far larger interest to ultimately distinguish among various tumor entities. EVs might increase the chance of early detection of chronic diseases or cancers especially if applied as part of yearly health screenings in the future. |
| first_indexed | 2024-12-10T21:01:02Z |
| format | Article |
| id | doaj.art-9beb3bbbebe34ca5a40953067317ba1b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-10T21:01:02Z |
| publishDate | 2014-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-9beb3bbbebe34ca5a40953067317ba1b2022-12-22T01:33:48ZengFrontiers Media S.A.Frontiers in Immunology1664-32242014-09-01510.3389/fimmu.2014.00413104860Extracellular vesicle profiling and their use as potential disease specific biomarkerHenrike eJulich0Arnulf eWillms1Veronika eLukacs-Kornek2Miroslaw eKornek3Miroslaw eKornek4Saarland University Medical CenterGerman Armed Forces Central HospitalSaarland University Medical CenterSaarland University Medical CenterGerman Armed Forces Central HospitalCell derived vesicles; in particular extracellular vesicles (EVs) such as microparticles (MPs) and microvesicles (MVs) besides exosomes are raising more and more attention as a novel and unique approach to detect diseases. It has recently become apparent, that disease specific MP signatures or profiles might be beneficial to differentiate chronic liver diseases such as non-alcoholic fatty liver disease (NAFLD) and chronic hepatitis C (CHC), to monitor their progression or possibly to assess treatment outcome. Therefore EVs might serve as a novel inexpensive and minimally invasive method to screen risk patients for the outbreak of a disease even before the initial symptoms, to follow up treatment complications and disease relapse. The purpose of the current review is to summarize already published EVs signatures for a limited number of exemplary diseases and to discuss their possible impact. Additionally, it will be discussed if the combination of EV profiling and miRNA profiling could be a future joint tool for the purpose of detecting cancer and from far larger interest to ultimately distinguish among various tumor entities. EVs might increase the chance of early detection of chronic diseases or cancers especially if applied as part of yearly health screenings in the future.http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00413/fullMicrovesiclesmiRNAsmicroparticlesextracellular vesiclesprofiling |
| spellingShingle | Henrike eJulich Arnulf eWillms Veronika eLukacs-Kornek Miroslaw eKornek Miroslaw eKornek Extracellular vesicle profiling and their use as potential disease specific biomarker Frontiers in Immunology Microvesicles miRNAs microparticles extracellular vesicles profiling |
| title | Extracellular vesicle profiling and their use as potential disease specific biomarker |
| title_full | Extracellular vesicle profiling and their use as potential disease specific biomarker |
| title_fullStr | Extracellular vesicle profiling and their use as potential disease specific biomarker |
| title_full_unstemmed | Extracellular vesicle profiling and their use as potential disease specific biomarker |
| title_short | Extracellular vesicle profiling and their use as potential disease specific biomarker |
| title_sort | extracellular vesicle profiling and their use as potential disease specific biomarker |
| topic | Microvesicles miRNAs microparticles extracellular vesicles profiling |
| url | http://journal.frontiersin.org/Journal/10.3389/fimmu.2014.00413/full |
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