A Diet Supplemented with Polyphenols, Prebiotics and Omega-3 Fatty Acids Modulates the Intestinal Microbiota and Improves the Profile of Metabolites Linked with Anxiety in Dogs
A nutrition-based approach was utilized to examine the effects of fish oil and a polyphenol blend (with or without tomato pomace) on the fecal microbiota and plasma/fecal metabolomes. Forty dogs, aged 5–14 years, were fed a washout food, then randomized to consume a control (fish oil and polyphenol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/11/7/976 |
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| author | Eden Ephraim Jeffrey A. Brockman Dennis E. Jewell |
| author_facet | Eden Ephraim Jeffrey A. Brockman Dennis E. Jewell |
| author_sort | Eden Ephraim |
| collection | DOAJ |
| description | A nutrition-based approach was utilized to examine the effects of fish oil and a polyphenol blend (with or without tomato pomace) on the fecal microbiota and plasma/fecal metabolomes. Forty dogs, aged 5–14 years, were fed a washout food, then randomized to consume a control (fish oil and polyphenol blend without tomato pomace) or test (fish oil and polyphenol blend with tomato pomace) food, then the washout food, and crossed over to consume the test or control food; each for 30 days. Several metabolites differed when comparing consumption of the washout with either the control or test foods, but few changed significantly between the test and control foods. Plasma levels of 4-ethylphenyl sulfate (4-EPS), a metabolite associated with anxiety disorders, demonstrated the largest decrease between the washout food and the control/test foods. Plasma 4-EPS levels were also significantly lower after dogs ate the test food compared with the control food. Other plasma metabolites linked with anxiety disorders were decreased following consumption of the control/test foods. Significant increases in <i>Blautia</i>, <i>Parabacteroides</i>, and <i>Odoribacter</i> in the fecal microbiota correlated with decreases in 4-EPS when dogs ate the control/test foods. These data indicate that foods supplemented with polyphenols and omega-3 fatty acids can modulate the gut microbiota to improve the profile of anxiety-linked metabolites. |
| first_indexed | 2024-03-09T12:14:03Z |
| format | Article |
| id | doaj.art-9beb7d7211d746f0bedc5e88fd27e4dd |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-09T12:14:03Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-9beb7d7211d746f0bedc5e88fd27e4dd2023-11-30T22:48:56ZengMDPI AGBiology2079-77372022-06-0111797610.3390/biology11070976A Diet Supplemented with Polyphenols, Prebiotics and Omega-3 Fatty Acids Modulates the Intestinal Microbiota and Improves the Profile of Metabolites Linked with Anxiety in DogsEden Ephraim0Jeffrey A. Brockman1Dennis E. Jewell2Pet Nutrition Center, Hill’s Pet Nutrition, Topeka, KS 66617, USAPet Nutrition Center, Hill’s Pet Nutrition, Topeka, KS 66617, USADepartment of Grain Science and Industry, Kansas State University, Manhattan, KS 66506, USAA nutrition-based approach was utilized to examine the effects of fish oil and a polyphenol blend (with or without tomato pomace) on the fecal microbiota and plasma/fecal metabolomes. Forty dogs, aged 5–14 years, were fed a washout food, then randomized to consume a control (fish oil and polyphenol blend without tomato pomace) or test (fish oil and polyphenol blend with tomato pomace) food, then the washout food, and crossed over to consume the test or control food; each for 30 days. Several metabolites differed when comparing consumption of the washout with either the control or test foods, but few changed significantly between the test and control foods. Plasma levels of 4-ethylphenyl sulfate (4-EPS), a metabolite associated with anxiety disorders, demonstrated the largest decrease between the washout food and the control/test foods. Plasma 4-EPS levels were also significantly lower after dogs ate the test food compared with the control food. Other plasma metabolites linked with anxiety disorders were decreased following consumption of the control/test foods. Significant increases in <i>Blautia</i>, <i>Parabacteroides</i>, and <i>Odoribacter</i> in the fecal microbiota correlated with decreases in 4-EPS when dogs ate the control/test foods. These data indicate that foods supplemented with polyphenols and omega-3 fatty acids can modulate the gut microbiota to improve the profile of anxiety-linked metabolites.https://www.mdpi.com/2079-7737/11/7/976anxiety4-ethylphenyl sulfatemetabolomemicrobiotagut-brain axis |
| spellingShingle | Eden Ephraim Jeffrey A. Brockman Dennis E. Jewell A Diet Supplemented with Polyphenols, Prebiotics and Omega-3 Fatty Acids Modulates the Intestinal Microbiota and Improves the Profile of Metabolites Linked with Anxiety in Dogs Biology anxiety 4-ethylphenyl sulfate metabolome microbiota gut-brain axis |
| title | A Diet Supplemented with Polyphenols, Prebiotics and Omega-3 Fatty Acids Modulates the Intestinal Microbiota and Improves the Profile of Metabolites Linked with Anxiety in Dogs |
| title_full | A Diet Supplemented with Polyphenols, Prebiotics and Omega-3 Fatty Acids Modulates the Intestinal Microbiota and Improves the Profile of Metabolites Linked with Anxiety in Dogs |
| title_fullStr | A Diet Supplemented with Polyphenols, Prebiotics and Omega-3 Fatty Acids Modulates the Intestinal Microbiota and Improves the Profile of Metabolites Linked with Anxiety in Dogs |
| title_full_unstemmed | A Diet Supplemented with Polyphenols, Prebiotics and Omega-3 Fatty Acids Modulates the Intestinal Microbiota and Improves the Profile of Metabolites Linked with Anxiety in Dogs |
| title_short | A Diet Supplemented with Polyphenols, Prebiotics and Omega-3 Fatty Acids Modulates the Intestinal Microbiota and Improves the Profile of Metabolites Linked with Anxiety in Dogs |
| title_sort | diet supplemented with polyphenols prebiotics and omega 3 fatty acids modulates the intestinal microbiota and improves the profile of metabolites linked with anxiety in dogs |
| topic | anxiety 4-ethylphenyl sulfate metabolome microbiota gut-brain axis |
| url | https://www.mdpi.com/2079-7737/11/7/976 |
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