Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review
Infective endocarditis (IE) is a bacterial infection with high morbidity and mortality rates, particularly among the elderly. This systematic review was conducted to determine the clinical characteristics of IE in older adults and the risk factors that could lead to adverse outcomes. The research em...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/2/296 |
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| author | Camelia Melania Budea Felix Bratosin Iulia Bogdan Adrian Vasile Bota Mirela Turaiche Livius Tirnea Carmen Nicoleta Stoica Andrei Nicolae Csep Bogdan Feciche Silvius Alexandru Pescariu Malina Popa Adelina Mavrea Bogdan Andrei Bumbu Satya Sai Sri Bandi Iosif Marincu |
| author_facet | Camelia Melania Budea Felix Bratosin Iulia Bogdan Adrian Vasile Bota Mirela Turaiche Livius Tirnea Carmen Nicoleta Stoica Andrei Nicolae Csep Bogdan Feciche Silvius Alexandru Pescariu Malina Popa Adelina Mavrea Bogdan Andrei Bumbu Satya Sai Sri Bandi Iosif Marincu |
| author_sort | Camelia Melania Budea |
| collection | DOAJ |
| description | Infective endocarditis (IE) is a bacterial infection with high morbidity and mortality rates, particularly among the elderly. This systematic review was conducted to determine the clinical characteristics of IE in older adults and the risk factors that could lead to adverse outcomes. The research employed three databases (PubMed, Wiley, and Web of Science), with a primary search for studies that have described cases of IE in patients older than 65 years. From a total of 555 articles, 10 were selected for inclusion in the current study, comprising a total of 2222 patients with a confirmed diagnosis of IE. The primary findings were an increased incidence of staphylococcal and streptococcal infections (33.4% and32.0%, respectively), an increased prevalence of comorbidities, namely, cardiovascular disease, diabetes, and cancer, and a significantly greater mortality risk than the younger group. Regarding mortality risks, the pooled odds ratio for cardiac disorders was OR = 3.81, septic shock OR = 8.22, renal complications OR = 3.75, and advancing age OR = 3.54 were most frequently mentioned. Taking into consideration the fact that the majority of the elderly population suffers from significant complications and is unable to undergo surgery due to an increased risk of complications after the procedure, it is imperative that effective treatment methods should be investigated. |
| first_indexed | 2024-03-11T08:34:47Z |
| format | Article |
| id | doaj.art-9bebdb4e0b0f428cb5267c46d36ee6e9 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-11T08:34:47Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-9bebdb4e0b0f428cb5267c46d36ee6e92023-11-16T21:33:27ZengMDPI AGJournal of Personalized Medicine2075-44262023-02-0113229610.3390/jpm13020296Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic ReviewCamelia Melania Budea0Felix Bratosin1Iulia Bogdan2Adrian Vasile Bota3Mirela Turaiche4Livius Tirnea5Carmen Nicoleta Stoica6Andrei Nicolae Csep7Bogdan Feciche8Silvius Alexandru Pescariu9Malina Popa10Adelina Mavrea11Bogdan Andrei Bumbu12Satya Sai Sri Bandi13Iosif Marincu14Department of Ear-Nose-Throat, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaMethodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaMethodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaMethodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaMethodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaMethodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaMethodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaMethodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Urology, Satu-Mare County Emergency Hospital, Strada Ravensburg 2, 440192 Satu-Mare, RomaniaDepartment VI, Cardiology, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Pedodontics, Faculty of Dental Medicine, “Victor Babes” University of Medicine and Pharmacy Timisoara, Revolutiei Boulevard 9, 300041 Timisoara, RomaniaDepartment of Internal Medicine I, Cardiology Clinic, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaDepartment of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, 410073 Oradea, RomaniaMalla Reddy Institute of Medical Sciences, Suraram Main Road 138, Hyderabad 500055, IndiaMethodological and Infectious Diseases Research Center, Department of Infectious Diseases, “Victor Babes” University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, RomaniaInfective endocarditis (IE) is a bacterial infection with high morbidity and mortality rates, particularly among the elderly. This systematic review was conducted to determine the clinical characteristics of IE in older adults and the risk factors that could lead to adverse outcomes. The research employed three databases (PubMed, Wiley, and Web of Science), with a primary search for studies that have described cases of IE in patients older than 65 years. From a total of 555 articles, 10 were selected for inclusion in the current study, comprising a total of 2222 patients with a confirmed diagnosis of IE. The primary findings were an increased incidence of staphylococcal and streptococcal infections (33.4% and32.0%, respectively), an increased prevalence of comorbidities, namely, cardiovascular disease, diabetes, and cancer, and a significantly greater mortality risk than the younger group. Regarding mortality risks, the pooled odds ratio for cardiac disorders was OR = 3.81, septic shock OR = 8.22, renal complications OR = 3.75, and advancing age OR = 3.54 were most frequently mentioned. Taking into consideration the fact that the majority of the elderly population suffers from significant complications and is unable to undergo surgery due to an increased risk of complications after the procedure, it is imperative that effective treatment methods should be investigated.https://www.mdpi.com/2075-4426/13/2/296infective endocarditispathogensmortalityrisk factorselderly patients |
| spellingShingle | Camelia Melania Budea Felix Bratosin Iulia Bogdan Adrian Vasile Bota Mirela Turaiche Livius Tirnea Carmen Nicoleta Stoica Andrei Nicolae Csep Bogdan Feciche Silvius Alexandru Pescariu Malina Popa Adelina Mavrea Bogdan Andrei Bumbu Satya Sai Sri Bandi Iosif Marincu Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review Journal of Personalized Medicine infective endocarditis pathogens mortality risk factors elderly patients |
| title | Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review |
| title_full | Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review |
| title_fullStr | Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review |
| title_full_unstemmed | Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review |
| title_short | Clinical Presentation and Risk Factors of Infective Endocarditis in the Elderly: A Systematic Review |
| title_sort | clinical presentation and risk factors of infective endocarditis in the elderly a systematic review |
| topic | infective endocarditis pathogens mortality risk factors elderly patients |
| url | https://www.mdpi.com/2075-4426/13/2/296 |
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