Silencing the Adipocytokine NOV: A Novel Approach to Reversing Oxidative Stress-Induced Cardiometabolic Dysfunction

Silencing the Adipocytokine NOV: A Novel Approach to Reversing Oxidative Stress-Induced Cardiometabolic Dysfunction

Objective: NOV/CCN3 is an adipocytokine recently linked to obesity, insulin resistance, and cardiometabolic dysfunction. NOV is manufactured and secreted from adipose tissue, with blood levels highly correlated with BMI. NOV levels are increased in obesity and a myriad of inflammatory diseases. Elev...

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Bibliographic Details
Main Authors: Maayan Waldman, Shailendra P. Singh, Hsin-Hsueh Shen, Ragin Alex, Rita Rezzani, Gaia Favero, Edith Hochhauser, Ran Kornowski, Michael Arad, Stephen J. Peterson
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
oxidative stress
metabolic syndrome
CCN3/NOV
heme oxygenase
PGC-1
mitochondria
Online Access:https://www.mdpi.com/2073-4409/11/19/3060

Internet

https://www.mdpi.com/2073-4409/11/19/3060

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