Two pediatric cases with hematuria, normal renal function and positive antineutrophil cytoplasmic antibodies
Antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis requires prompt diagnosis and treatment, since renal function at the time of diagnosis is significantly associated with renal outcomes. Here, we report two pediatric patients with ANCA-positive glomerulonephritis initially pres...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Society of Pediatric Nephrology
2022-12-01
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| Series: | Childhood Kidney Diseases |
| Subjects: | |
| Online Access: | http://chikd.org/upload/pdf/ckd-22-031.pdf |
| _version_ | 1811161565192257536 |
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| author | Ji Hyeon Lim Ji Won Jung Heoun Jeong Go Joo Hoon Lee Young Seo Park |
| author_facet | Ji Hyeon Lim Ji Won Jung Heoun Jeong Go Joo Hoon Lee Young Seo Park |
| author_sort | Ji Hyeon Lim |
| collection | DOAJ |
| description | Antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis requires prompt diagnosis and treatment, since renal function at the time of diagnosis is significantly associated with renal outcomes. Here, we report two pediatric patients with ANCA-positive glomerulonephritis initially presenting with hematuria, mild proteinuria, and normal renal function. The first patient with a high myeloperoxidase-ANCA titer (>134 IU/mL) was diagnosed with rapidly progressive glomerulonephritis based on renal biopsy and treated with immunosuppressive therapy after 10 months of follow-up. The second patient with a low myeloperoxidase-ANCA titer (11 IU/mL) maintained normal kidney function without medication. Two cases showed different clinical course according to ANCA titer. |
| first_indexed | 2024-04-10T06:17:32Z |
| format | Article |
| id | doaj.art-9becf642f56748ddbf88f5bd5de347d3 |
| institution | Directory Open Access Journal |
| issn | 2384-0242 2384-0250 |
| language | English |
| last_indexed | 2024-04-10T06:17:32Z |
| publishDate | 2022-12-01 |
| publisher | Korean Society of Pediatric Nephrology |
| record_format | Article |
| series | Childhood Kidney Diseases |
| spelling | doaj.art-9becf642f56748ddbf88f5bd5de347d32023-03-02T06:33:50ZengKorean Society of Pediatric NephrologyChildhood Kidney Diseases2384-02422384-02502022-12-01262869010.3339/ckd.22.031769Two pediatric cases with hematuria, normal renal function and positive antineutrophil cytoplasmic antibodiesJi Hyeon Lim0Ji Won Jung1Heoun Jeong Go2Joo Hoon Lee3Young Seo Park4 Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea Department of Pathology, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, Republic of Korea Department of Pediatrics, Asan Medical Center Children’s Hospital, University of Ulsan College of Medicine, Seoul, Republic of KoreaAntineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis requires prompt diagnosis and treatment, since renal function at the time of diagnosis is significantly associated with renal outcomes. Here, we report two pediatric patients with ANCA-positive glomerulonephritis initially presenting with hematuria, mild proteinuria, and normal renal function. The first patient with a high myeloperoxidase-ANCA titer (>134 IU/mL) was diagnosed with rapidly progressive glomerulonephritis based on renal biopsy and treated with immunosuppressive therapy after 10 months of follow-up. The second patient with a low myeloperoxidase-ANCA titer (11 IU/mL) maintained normal kidney function without medication. Two cases showed different clinical course according to ANCA titer.http://chikd.org/upload/pdf/ckd-22-031.pdfantineutrophil cytoplasmic antibodycase reportsglomerulonephritisvasculitis |
| spellingShingle | Ji Hyeon Lim Ji Won Jung Heoun Jeong Go Joo Hoon Lee Young Seo Park Two pediatric cases with hematuria, normal renal function and positive antineutrophil cytoplasmic antibodies Childhood Kidney Diseases antineutrophil cytoplasmic antibody case reports glomerulonephritis vasculitis |
| title | Two pediatric cases with hematuria, normal renal function and positive antineutrophil cytoplasmic antibodies |
| title_full | Two pediatric cases with hematuria, normal renal function and positive antineutrophil cytoplasmic antibodies |
| title_fullStr | Two pediatric cases with hematuria, normal renal function and positive antineutrophil cytoplasmic antibodies |
| title_full_unstemmed | Two pediatric cases with hematuria, normal renal function and positive antineutrophil cytoplasmic antibodies |
| title_short | Two pediatric cases with hematuria, normal renal function and positive antineutrophil cytoplasmic antibodies |
| title_sort | two pediatric cases with hematuria normal renal function and positive antineutrophil cytoplasmic antibodies |
| topic | antineutrophil cytoplasmic antibody case reports glomerulonephritis vasculitis |
| url | http://chikd.org/upload/pdf/ckd-22-031.pdf |
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