Upregulation of DAB2IP Inhibits Ras Activity and Tumorigenesis in Human Pancreatic Cancer Cells

Upregulation of DAB2IP Inhibits Ras Activity and Tumorigenesis in Human Pancreatic Cancer Cells

KRAS mutation-induced Ras activation plays an important role in the pathogenesis of pancreatic cancer, but the role of wild-type Ras and Ras GTPase-activating proteins remains unclear. The present study was designed to determine the expression spectra of Ras GTPase-activating proteins genes in pancr...

Full description

Bibliographic Details
Main Authors:	Yifan Duan MD, PhD, Xiaoyu Yin MD, PhD, Xiaorong Lai MD, PhD, Chao Liu MD, PhD, Wenjing Nie MD, MM, Dongfeng Li MM, Zijun Xie MD, PhD, Zijun Li MD, PhD, Fan Meng MD, PhD
Format:	Article
Language:	English
Published:	SAGE Publishing 2020-04-01
Series:	Technology in Cancer Research & Treatment
Online Access:	https://doi.org/10.1177/1533033819895494

Similar Items

Identification of Key Modules and Hub Genes Involved in Esophageal Squamous Cell Carcinoma Tumorigenesis Using WCGNA
by: Nanzheng Chen MD, PhD, et al.
Published: (2020-12-01)

Calreticulin Upregulation in Cervical Cancer Tissues From Patients After 10 Gy Radiation Therapy
by: Kohei Okada, MD, et al.
Published: (2023-05-01)

Successful Laparoscopic Treatment of Pancreatic Metastasis From Sigmoid Colon Cancer: A Case Report
by: Masatsugu Ishii MD, PhD, et al.
Published: (2022-04-01)

Neoadjuvant Chemoradiotherapy Upregulates the Immunogenicity of Cold to Hot Tumors in Esophageal Cancer Patients
by: Yushi Nagaki, MD, PhD, et al.
Published: (2024-03-01)

Pancreatic stent removal with a novel drill dilator
by: Takafumi Yanaidani, MD, et al.
Published: (2024-05-01)

Predictors of occult metastases in potentially Resectable pancreatic ductal adenocarcinoma
by: Takeshi Murakami, MD, et al.
Published: (2024-08-01)

Endoscopic nasobiliary drainage tube placement through a periampullary perforation for management of intestinal leak and necrotizing pancreatitis
by: Mitsuru Okuno, MD, PhD, et al.
Published: (2023-02-01)

Successful EUS-guided nondilated pancreatic duct stent placement in patient with refractory pancreatic fistula after pancreaticoduodenectomy
by: Kazuhiro Minami, MD, et al.
Published: (2017-11-01)

Upregulation of PKN1 as a Prognosis Biomarker for Endometrial Cancer
by: Igor Govorov MD, PhD, et al.
Published: (2022-04-01)

Clinical Outcomes of Proton Beam Therapy for Unresectable Locally Advanced Pancreatic Cancer: A Single-Center Retrospective Study
by: Ichiro Seto, MD, DMD, PhD, et al.
Published: (2024-10-01)

Endoscopic recovery of multiple migrated plastic stents during EUS-guided transmural drainage of pancreatic fluid collections
by: Takao Nishikawa, MD, PhD, et al.
Published: (2017-03-01)

Diagnostic Accuracy of Lipase as Early Predictor of Postoperative Pancreatic Fistula: Results from the LIPADRAIN study
by: Béranger Doussot, MD, et al.
Published: (2024-09-01)

A Novel LncRNA SNHG3 Promotes Osteoblast Differentiation Through BMP2 Upregulation in Aortic Valve Calcification
by: Long Chen, MD, et al.
Published: (2022-09-01)

Preoperative Decision to Perform Portal Vein Resection Improves Survival in Patients With Resectable Pancreatic Head Cancer Adjacent to Portal Vein
by: Muga Terasawa, MD, et al.
Published: (2021-06-01)

Pancreatic lipoma with a solid nodule mimicking invasion from adjoining intraductal papillary mucinous neoplasm
by: Yoko Namiki, MD, et al.
Published: (2016-06-01)

Cost-Effectiveness Analysis of First-Line FOLFIRI Combined With Cetuximab or Bevacizumab in Patients With RAS Wild-Type Left-Sided Metastatic Colorectal Cancer
by: Jiaqi Han MD, et al.
Published: (2020-02-01)

Endoscopic replacement technique for migrated lumen-apposing metal stent during endoscopic pancreatic necrosectomy
by: Mitsuru Okuno, MD, PhD, et al.
Published: (2019-05-01)

A case of improved quality of life in a patient with inoperable pancreatic cancer after repeated RFA
by: Nino Toria, MD, et al.
Published: (2022-10-01)

Preoperative Biliary Drainage Does Not Independently Reduce Survival After Pancreaticoduodenectomy Among Patients With Pancreatic Ductal Adenocarcinoma
by: Karin Johansen, MD, et al.
Published: (2021-09-01)

Prophylactic splenic artery embolization using n-butyl-2-cyanoacrylate and coils prior to endoscopic necrosectomy in a patient with necrotizing pancreatitis: A case report
by: Hiroki Kamada, MD, PhD, et al.
Published: (2024-08-01)

Outcomes of Islet Autotransplantation in Chronic Pancreatitis Patients with Complete Acinar Atrophy
by: Gumpei Yoshimatsu MD, PhD, et al.
Published: (2020-09-01)

The MEK Inhibitor Trametinib Suppresses Major Histocompatibility Antigen-mismatched Rejection Following Pancreatic Islet Transplantation
by: Seiichiro Tada, MD, et al.
Published: (2020-09-01)

Impact of Hypothermic Perfusion on Immune Responses and Sterile Inflammation in a Preclinical Model of Pancreatic Transplantation
by: Benoit Mesnard, MD, et al.
Published: (2025-01-01)

A case of endoscopic minor duodenal papillectomy after pancreatic stent placement using an endoscopic ultrasonography-guided rendezvous method
by: Sho Takahashi, MD, et al.
Published: (2022-06-01)

Successful management of bile duct injury with duodenal perforation using endoscopic naso-pancreatic drainage and fully covered self-expandable metallic stent deployment
by: Haruka Okada, MD, et al.
Published: (2024-03-01)

Peroral cholangioscopy–guided probe-based confocal laser endomicroscopy for preoperative diagnosis of pancreatic cancer in a patient with surgically altered anatomy
by: Yuki Tanisaka, MD, PhD, et al.
Published: (2020-03-01)

Allergic and hypersensitivity condition in the International Patients’ Summary (IPS) standard: The need of updates through the International Classification of Diseases (ICD)-11
by: Luciana Kase Tanno, MD, PhD, et al.
Published: (2024-08-01)

Aging is Associated With Constipation in Japanese Patients With Ulcerative Colitis: A Post Hoc Analysis
by: Sen Yagi MD, PhD, et al.
Published: (2023-11-01)

The Efficacy and Safety of Sacubitril/Valsartan in Heart Failure Patients: A Review
by: Rui Zhang MD, PhD, et al.
Published: (2022-01-01)

Clinical Features and Computed Tomography Radiomics-Based Model for Predicting Pancreatic Ductal Adenocarcinoma and Focal Mass-Forming Pancreatitis
by: Yingjian Ye MD, et al.
Published: (2023-06-01)

Long-term Prognosis and Recurrence of Primary Sclerosing Cholangitis After Liver Transplantation: A Single-Center Experience
by: Yoshihide Ueda, MD, PhD, et al.
Published: (2017-12-01)

Multicenter, Retrospective Study to Evaluate Necitumumab Plus Cisplatin and Gemcitabine After Immune Checkpoint Inhibitors in Advanced Squamous Cell Lung Cancer in Japan: The NINJA Study
by: Yasunori Murata, MD, PhD, et al.
Published: (2023-12-01)

Upregulation of Coagulation Factor VIII and Fibrinogen After Pulmonary Endarterectomy in Patients with Chronic Thromboembolic Pulmonary Hypertension
by: Lasse Myllylahti MD, et al.
Published: (2023-03-01)

Efficacy and Safety of Allogeneic Islet Transplantation Demonstrated by a Multicenter Clinical Trial in Japan
by: Takayuki Anazawa, MD, PhD, et al.
Published: (2025-03-01)

Impact of pleural effusion at an early period after posterior spinal fusion for adolescent idiopathic scoliosis on future pulmonary function and lung volume
by: Masahiro Ozaki, MD, PhD, et al.
Published: (2023-12-01)

Severe Antithrombin Deficiency May be Associated With a High Risk of Pathological Progression of DIC With Suppressed Fibrinolysis
by: Hideo Wada MD, PhD, et al.
Published: (2020-08-01)

Final Analysis Data and Exploratory Biomarker Analysis of a Randomized Phase 2 Study of Osimertinib Plus Bevacizumab Versus Osimertinib Monotherapy for Untreated Patients With Nonsquamous NSCLC Harboring EGFR Mutations: The WJOG9717L Study
by: Hirotsugu Kenmotsu, MD, PhD, et al.
Published: (2024-11-01)

Prognostic role of preoperative fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography with an image-based harmonization technique: A multicenter retrospective studyCentral MessagePerspective
by: Akira Hamada, MD, PhD, et al.
Published: (2023-06-01)

Comparing Three Different Anti–Programmed Death-Ligand 1 Antibodies in Immunohistochemical Evaluation of Combined Chemoimmunotherapy Response in Patients With NSCLC: A Prospective Study
by: Yuki Katayama, MD, PhD, et al.
Published: (2024-03-01)

Solid Predominant Histology and High Podoplanin Expression in Cancer-Associated Fibroblast Predict Primary Resistance to Osimertinib in EGFR-Mutated Lung Adenocarcinoma
by: Yuji Uehara, MD, et al.
Published: (2025-03-01)