Lupus Panniculitis in Association with Anti-Phospholipid Antibody Syndrome on a Background of Systemic Lupus Erythematosus: A Case Report and Literature Review
Lupus panniculitis occurs in 1–3% of the patients diagnosed with systemic lupus erythematosus (SLE) and 10% of the patients diagnosed with discoid lupus erythematosus (DLE). It is a disorder of autoimmune origin, manifesting as deep erythematous plaques and nodules involving the trunk, breasts, butt...
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| Format: | Article |
| Language: | English |
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European Medical Journal
2020-04-01
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| Series: | European Medical Journal Allergy & Immunology |
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| Online Access: | https://www.emjreviews.com/allergy-immunology/article/lupus-panniculitis-in-association-with-anti-phospholipid-antibody-syndrome-on-a-background-of-systemic-lupus-erythematosus-a-case-report-and-literature-review/ |
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| author | Abu Bakar Tauseef Muhammad Sohaib Asghar Narmin Khan Uzma Rasheed Munir Hussain Siddiqui Umar Farooq Marium Tauseef |
| author_facet | Abu Bakar Tauseef Muhammad Sohaib Asghar Narmin Khan Uzma Rasheed Munir Hussain Siddiqui Umar Farooq Marium Tauseef |
| author_sort | Abu Bakar Tauseef |
| collection | DOAJ |
| description | Lupus panniculitis occurs in 1–3% of the patients diagnosed with systemic lupus erythematosus (SLE) and 10% of the patients diagnosed with discoid lupus erythematosus (DLE). It is a disorder of autoimmune origin, manifesting as deep erythematous plaques and nodules involving the trunk, breasts, buttocks, face, and proximal extremities. It does not commonly ulcerate. This report highlights the case of a 22-year-old Asian female with a history of coeliac disease and significant family history of antiphospholipid antibody syndrome (APS) who presented with fever, malaise, weight loss, and subcutaneous non-tender nodules over the forearm, back, bilateral thighs, and feet. Laboratory investigations revealed positive antinuclear antibodies, anti-Ro/SSA antibody, and lupus anticoagulant, resulting in a diagnosis of APS. Biopsies of lesions were consistent with findings of lupus panniculitis. Every case of SLE and DLE with discrete skin lesions should be reviewed for any distinct entity such as lupus panniculitis, as it may be associated with greater risk of flares and systemic involvement. The purpose of this case report is to emphasise that early diagnosis and prompt treatment is crucial to improving the prognosis of such patients. |
| first_indexed | 2024-12-11T07:49:50Z |
| format | Article |
| id | doaj.art-9bef8b73d6854cb985b08c5fa7c5298d |
| institution | Directory Open Access Journal |
| issn | 2398-9130 |
| language | English |
| last_indexed | 2024-12-11T07:49:50Z |
| publishDate | 2020-04-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal Allergy & Immunology |
| spelling | doaj.art-9bef8b73d6854cb985b08c5fa7c5298d2022-12-22T01:15:22ZengEuropean Medical JournalEuropean Medical Journal Allergy & Immunology2398-91302020-04-0110.33590/emjallergyimmunol/19-00195Lupus Panniculitis in Association with Anti-Phospholipid Antibody Syndrome on a Background of Systemic Lupus Erythematosus: A Case Report and Literature ReviewAbu Bakar Tauseef0Muhammad Sohaib Asghar1Narmin Khan2Uzma Rasheed3Munir Hussain Siddiqui4Umar Farooq5Marium Tauseef6Dow University Hospital, Dow University of Health Sciences, Karachi, PakistanDow University Hospital, Dow University of Health Sciences, Karachi, PakistanDow University Hospital, Dow University of Health Sciences, Karachi, PakistanLiaquat National Hospital and Medical College, Karachi, PakistanDow University Hospital, Dow University of Health Sciences, Karachi, PakistanPatel Hospital, Karachi, PakistanJinnah Sindh Medical University, Karachi, PakistanLupus panniculitis occurs in 1–3% of the patients diagnosed with systemic lupus erythematosus (SLE) and 10% of the patients diagnosed with discoid lupus erythematosus (DLE). It is a disorder of autoimmune origin, manifesting as deep erythematous plaques and nodules involving the trunk, breasts, buttocks, face, and proximal extremities. It does not commonly ulcerate. This report highlights the case of a 22-year-old Asian female with a history of coeliac disease and significant family history of antiphospholipid antibody syndrome (APS) who presented with fever, malaise, weight loss, and subcutaneous non-tender nodules over the forearm, back, bilateral thighs, and feet. Laboratory investigations revealed positive antinuclear antibodies, anti-Ro/SSA antibody, and lupus anticoagulant, resulting in a diagnosis of APS. Biopsies of lesions were consistent with findings of lupus panniculitis. Every case of SLE and DLE with discrete skin lesions should be reviewed for any distinct entity such as lupus panniculitis, as it may be associated with greater risk of flares and systemic involvement. The purpose of this case report is to emphasise that early diagnosis and prompt treatment is crucial to improving the prognosis of such patients.https://www.emjreviews.com/allergy-immunology/article/lupus-panniculitis-in-association-with-anti-phospholipid-antibody-syndrome-on-a-background-of-systemic-lupus-erythematosus-a-case-report-and-literature-review/autoimmunebiopsydiscoidlupuspanniculitis |
| spellingShingle | Abu Bakar Tauseef Muhammad Sohaib Asghar Narmin Khan Uzma Rasheed Munir Hussain Siddiqui Umar Farooq Marium Tauseef Lupus Panniculitis in Association with Anti-Phospholipid Antibody Syndrome on a Background of Systemic Lupus Erythematosus: A Case Report and Literature Review European Medical Journal Allergy & Immunology autoimmune biopsy discoid lupus panniculitis |
| title | Lupus Panniculitis in Association with Anti-Phospholipid Antibody Syndrome on a Background of Systemic Lupus Erythematosus: A Case Report and Literature Review |
| title_full | Lupus Panniculitis in Association with Anti-Phospholipid Antibody Syndrome on a Background of Systemic Lupus Erythematosus: A Case Report and Literature Review |
| title_fullStr | Lupus Panniculitis in Association with Anti-Phospholipid Antibody Syndrome on a Background of Systemic Lupus Erythematosus: A Case Report and Literature Review |
| title_full_unstemmed | Lupus Panniculitis in Association with Anti-Phospholipid Antibody Syndrome on a Background of Systemic Lupus Erythematosus: A Case Report and Literature Review |
| title_short | Lupus Panniculitis in Association with Anti-Phospholipid Antibody Syndrome on a Background of Systemic Lupus Erythematosus: A Case Report and Literature Review |
| title_sort | lupus panniculitis in association with anti phospholipid antibody syndrome on a background of systemic lupus erythematosus a case report and literature review |
| topic | autoimmune biopsy discoid lupus panniculitis |
| url | https://www.emjreviews.com/allergy-immunology/article/lupus-panniculitis-in-association-with-anti-phospholipid-antibody-syndrome-on-a-background-of-systemic-lupus-erythematosus-a-case-report-and-literature-review/ |
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