Evaluation of the bone morphology around four types of porous metal implants placed in distal femur of ovariectomized rats
Abstract Background To compare structural features of the femoral bone of ovariectomized and non-ovariectomized rats after implantation of porous materials (TANTALUM, CONCELOC, TTM, ATLANT). Methods Experiments were carried out on 56 white laboratory female rats aged 6 months. Rats were randomly ass...
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| Format: | Article |
| Language: | English |
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BMC
2020-08-01
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| Series: | Journal of Orthopaedic Surgery and Research |
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| Online Access: | http://link.springer.com/article/10.1186/s13018-020-01822-3 |
| _version_ | 1798042207326830592 |
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| author | Stanislav Bondarenko Nataliya Ashukina Valentyna Maltseva Gennadiy Ivanov Ahmed Amine Badnaoui Ran Schwarzkopf |
| author_facet | Stanislav Bondarenko Nataliya Ashukina Valentyna Maltseva Gennadiy Ivanov Ahmed Amine Badnaoui Ran Schwarzkopf |
| author_sort | Stanislav Bondarenko |
| collection | DOAJ |
| description | Abstract Background To compare structural features of the femoral bone of ovariectomized and non-ovariectomized rats after implantation of porous materials (TANTALUM, CONCELOC, TTM, ATLANT). Methods Experiments were carried out on 56 white laboratory female rats aged 6 months. Rats were randomly assigned into groups: sham-operated control group (SH) or ovariectomy group (OVX). Four different commercial implant materials (TTM, CONCELOC, TANTALUM, ATLANT) were placed into the defects (diameter 2.5 mm, depth 3.0 mm) in the distal metaphysis of femurs. Rats were sacrificed 45 days after surgery. Histological study was performed and the percentage of the bone area (BA%) around the implant at a distance of 500 μm in the cancellous area was measured. Results Formation of mature bone tissue of varying degrees around all of the implants was detected. In OVX rats cancellous bone defect zone was characterized by a high density of osteocytes on the surface. In the SH group, no differences in BA% among implant materials were found. In OVX rats, the BA% around ATLANT implants was 1.5-time less (p = 0.002) than around TANTALUM. The BA% around the rest of the materials was not statistically different. Conclusions Bone formation around the studied porous titanium and tantalum materials in the osteoporosis model was lower than in normal bone. There were differences in bone formation around the different materials in the osteoporosis model, while in the normal bone model, these differences were absent. |
| first_indexed | 2024-04-11T22:32:15Z |
| format | Article |
| id | doaj.art-9befde7482bb4c5c8cfe78c879953b71 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-04-11T22:32:15Z |
| publishDate | 2020-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-9befde7482bb4c5c8cfe78c879953b712022-12-22T03:59:20ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2020-08-011511710.1186/s13018-020-01822-3Evaluation of the bone morphology around four types of porous metal implants placed in distal femur of ovariectomized ratsStanislav Bondarenko0Nataliya Ashukina1Valentyna Maltseva2Gennadiy Ivanov3Ahmed Amine Badnaoui4Ran Schwarzkopf5Dept of Joint Pathology, Sytenko Institute of Spine and Joint Pathology, National Academy of Medical Sciences of UkraineDept of Joint Pathology, Sytenko Institute of Spine and Joint Pathology, National Academy of Medical Sciences of UkraineDept of Joint Pathology, Sytenko Institute of Spine and Joint Pathology, National Academy of Medical Sciences of UkraineDept of Joint Pathology, Sytenko Institute of Spine and Joint Pathology, National Academy of Medical Sciences of UkraineDept of Joint Pathology, Sytenko Institute of Spine and Joint Pathology, National Academy of Medical Sciences of UkraineNYU Langone Medical Center, Hospital for Joint DiseasesAbstract Background To compare structural features of the femoral bone of ovariectomized and non-ovariectomized rats after implantation of porous materials (TANTALUM, CONCELOC, TTM, ATLANT). Methods Experiments were carried out on 56 white laboratory female rats aged 6 months. Rats were randomly assigned into groups: sham-operated control group (SH) or ovariectomy group (OVX). Four different commercial implant materials (TTM, CONCELOC, TANTALUM, ATLANT) were placed into the defects (diameter 2.5 mm, depth 3.0 mm) in the distal metaphysis of femurs. Rats were sacrificed 45 days after surgery. Histological study was performed and the percentage of the bone area (BA%) around the implant at a distance of 500 μm in the cancellous area was measured. Results Formation of mature bone tissue of varying degrees around all of the implants was detected. In OVX rats cancellous bone defect zone was characterized by a high density of osteocytes on the surface. In the SH group, no differences in BA% among implant materials were found. In OVX rats, the BA% around ATLANT implants was 1.5-time less (p = 0.002) than around TANTALUM. The BA% around the rest of the materials was not statistically different. Conclusions Bone formation around the studied porous titanium and tantalum materials in the osteoporosis model was lower than in normal bone. There were differences in bone formation around the different materials in the osteoporosis model, while in the normal bone model, these differences were absent.http://link.springer.com/article/10.1186/s13018-020-01822-3TantalumTitaniumOsteoporosisAnimal modelBone remodelingHistology |
| spellingShingle | Stanislav Bondarenko Nataliya Ashukina Valentyna Maltseva Gennadiy Ivanov Ahmed Amine Badnaoui Ran Schwarzkopf Evaluation of the bone morphology around four types of porous metal implants placed in distal femur of ovariectomized rats Journal of Orthopaedic Surgery and Research Tantalum Titanium Osteoporosis Animal model Bone remodeling Histology |
| title | Evaluation of the bone morphology around four types of porous metal implants placed in distal femur of ovariectomized rats |
| title_full | Evaluation of the bone morphology around four types of porous metal implants placed in distal femur of ovariectomized rats |
| title_fullStr | Evaluation of the bone morphology around four types of porous metal implants placed in distal femur of ovariectomized rats |
| title_full_unstemmed | Evaluation of the bone morphology around four types of porous metal implants placed in distal femur of ovariectomized rats |
| title_short | Evaluation of the bone morphology around four types of porous metal implants placed in distal femur of ovariectomized rats |
| title_sort | evaluation of the bone morphology around four types of porous metal implants placed in distal femur of ovariectomized rats |
| topic | Tantalum Titanium Osteoporosis Animal model Bone remodeling Histology |
| url | http://link.springer.com/article/10.1186/s13018-020-01822-3 |
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