Comparison of prognostic value of N-terminal pro-brain natriuretic peptide in septic and non-septic intensive care patients
Introduction : The aim of this study is to compare the prognostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in septic and non-septic intensive care patients. Material and methods : Fifty consecutive patients admitted to the intensive care unit (ICU) were enrolled in eith...
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| Format: | Article |
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Termedia Publishing House
2017-02-01
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| Series: | Archives of Medical Science |
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| Online Access: | https://www.termedia.pl/Comparison-of-prognostic-value-of-N-terminal-pro-brain-natriuretic-peptide-in-septic-and-non-septic-intensive-care-patients,19,25773,1,1.html |
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| author | Namik Ozcan Ayse Ozcan Cetin Kaymak Hulya Basar Mustafa Kotanoglu Bektas Kose |
| author_facet | Namik Ozcan Ayse Ozcan Cetin Kaymak Hulya Basar Mustafa Kotanoglu Bektas Kose |
| author_sort | Namik Ozcan |
| collection | DOAJ |
| description | Introduction : The aim of this study is to compare the prognostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in septic and non-septic intensive care patients.
Material and methods : Fifty consecutive patients admitted to the intensive care unit (ICU) were enrolled in either the septic or non-septic group according to the criteria in the International Sepsis Definitions Conference in 2001. Demographic and clinical data, procalcitonin and lactate levels at admission, and death within 28 days were registered. Five blood samples were collected from all patients for NT-proBNP measurements.
Results: Septic patients had higher APACHE II (19 (16.00–24.25) vs. 16 (13.00–18.25)), and SOFA (8 (5–10) vs. 6 (4–7)) scores (p <0.05). Procalcitonin levels were also higher in septic patients (3.33 (1.06–10.96) vs. 0.46 (0.26–1.01) ng/ml) and more patients required vasopressors in this group (9 (36%) vs. 2 (8%)) (p < 0.05). In the septic group, the correlation between mortality and the level of NT-proBNP was significant for each measurement, starting from the admission. In the non-septic group the correlation between mortality and the level of NT-proBNP was significant only at the 120th h.
Conclusions : We concluded that the level of NT-proBNP at admission is well correlated with 28-day mortality in septic ICU patients. However, single measurement of NT-proBNP levels in non-septic patients does not correlate with the 28-day mortality. Repeated measurements and an increasing trend of the NT-proBNP levels may show a correlation with mortality in non-septic intensive care patients. |
| first_indexed | 2024-12-12T02:07:31Z |
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| id | doaj.art-9bf475672d2a4aa6a652e95d6e01a9aa |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-12-12T02:07:31Z |
| publishDate | 2017-02-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-9bf475672d2a4aa6a652e95d6e01a9aa2022-12-22T00:42:01ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512017-02-0113241842510.5114/aoms.2015.5419625773Comparison of prognostic value of N-terminal pro-brain natriuretic peptide in septic and non-septic intensive care patientsNamik OzcanAyse OzcanCetin KaymakHulya BasarMustafa KotanogluBektas KoseIntroduction : The aim of this study is to compare the prognostic value of N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in septic and non-septic intensive care patients. Material and methods : Fifty consecutive patients admitted to the intensive care unit (ICU) were enrolled in either the septic or non-septic group according to the criteria in the International Sepsis Definitions Conference in 2001. Demographic and clinical data, procalcitonin and lactate levels at admission, and death within 28 days were registered. Five blood samples were collected from all patients for NT-proBNP measurements. Results: Septic patients had higher APACHE II (19 (16.00–24.25) vs. 16 (13.00–18.25)), and SOFA (8 (5–10) vs. 6 (4–7)) scores (p <0.05). Procalcitonin levels were also higher in septic patients (3.33 (1.06–10.96) vs. 0.46 (0.26–1.01) ng/ml) and more patients required vasopressors in this group (9 (36%) vs. 2 (8%)) (p < 0.05). In the septic group, the correlation between mortality and the level of NT-proBNP was significant for each measurement, starting from the admission. In the non-septic group the correlation between mortality and the level of NT-proBNP was significant only at the 120th h. Conclusions : We concluded that the level of NT-proBNP at admission is well correlated with 28-day mortality in septic ICU patients. However, single measurement of NT-proBNP levels in non-septic patients does not correlate with the 28-day mortality. Repeated measurements and an increasing trend of the NT-proBNP levels may show a correlation with mortality in non-septic intensive care patients.https://www.termedia.pl/Comparison-of-prognostic-value-of-N-terminal-pro-brain-natriuretic-peptide-in-septic-and-non-septic-intensive-care-patients,19,25773,1,1.htmlNT-proBNP intensive care unit patient outcome assessment critically ill |
| spellingShingle | Namik Ozcan Ayse Ozcan Cetin Kaymak Hulya Basar Mustafa Kotanoglu Bektas Kose Comparison of prognostic value of N-terminal pro-brain natriuretic peptide in septic and non-septic intensive care patients Archives of Medical Science NT-proBNP intensive care unit patient outcome assessment critically ill |
| title | Comparison of prognostic value of N-terminal pro-brain natriuretic peptide in septic and non-septic intensive care patients |
| title_full | Comparison of prognostic value of N-terminal pro-brain natriuretic peptide in septic and non-septic intensive care patients |
| title_fullStr | Comparison of prognostic value of N-terminal pro-brain natriuretic peptide in septic and non-septic intensive care patients |
| title_full_unstemmed | Comparison of prognostic value of N-terminal pro-brain natriuretic peptide in septic and non-septic intensive care patients |
| title_short | Comparison of prognostic value of N-terminal pro-brain natriuretic peptide in septic and non-septic intensive care patients |
| title_sort | comparison of prognostic value of n terminal pro brain natriuretic peptide in septic and non septic intensive care patients |
| topic | NT-proBNP intensive care unit patient outcome assessment critically ill |
| url | https://www.termedia.pl/Comparison-of-prognostic-value-of-N-terminal-pro-brain-natriuretic-peptide-in-septic-and-non-septic-intensive-care-patients,19,25773,1,1.html |
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