In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain.
<h4>Background</h4>Whether immunosuppressed (IS) patients have a worse prognosis of COVID-19 compared to non-IS patients is not known. The aim of this study was to evaluate the clinical characteristics and outcome of IS patients hospitalized with COVID-19 compared to non-IS patients.<...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0255524 |
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| author | Inés Suárez-García Isabel Perales-Fraile Andrés González-García Arturo Muñoz-Blanco Luis Manzano Martín Fabregate Jesús Díez-Manglano Eva Fonseca Aizpuru Francisco Arnalich Fernández Alejandra García García Ricardo Gómez-Huelgas José-Manuel Ramos-Rincón SEMI-COVID-19 Network |
| author_facet | Inés Suárez-García Isabel Perales-Fraile Andrés González-García Arturo Muñoz-Blanco Luis Manzano Martín Fabregate Jesús Díez-Manglano Eva Fonseca Aizpuru Francisco Arnalich Fernández Alejandra García García Ricardo Gómez-Huelgas José-Manuel Ramos-Rincón SEMI-COVID-19 Network |
| author_sort | Inés Suárez-García |
| collection | DOAJ |
| description | <h4>Background</h4>Whether immunosuppressed (IS) patients have a worse prognosis of COVID-19 compared to non-IS patients is not known. The aim of this study was to evaluate the clinical characteristics and outcome of IS patients hospitalized with COVID-19 compared to non-IS patients.<h4>Methods</h4>We designed a retrospective cohort study. We included all patients hospitalized with laboratory-confirmed COVID-19 from the SEMI-COVID-19 Registry, a large multicentre national cohort in Spain, from March 27th until June 19th, 2020. We used multivariable logistic regression to assess the adjusted odds ratios (aOR) of in-hospital death among IS compared to non-IS patients.<h4>Results</h4>Among 13 206 included patients, 2 111 (16.0%) were IS. A total of 166 (1.3%) patients had solid organ (SO) transplant, 1081 (8.2%) had SO neoplasia, 332 (2.5%) had hematologic neoplasia, and 570 (4.3%), 183 (1.4%) and 394 (3.0%) were receiving systemic steroids, biological treatments, and immunosuppressors, respectively. Compared to non-IS patients, the aOR (95% CI) for in-hospital death was 1.60 (1.43-1.79) for all IS patients, 1.39 (1.18-1.63) for patients with SO cancer, 2.31 (1.76-3.03) for patients with haematological cancer and 3.12 (2.23-4.36) for patients with SO transplant. The aOR (95% CI) for death for patients who were receiving systemic steroids, biological treatments and immunosuppressors compared to non-IS patients were 2.16 (1.80-2.61), 1.97 (1.33-2.91) and 2.06 (1.64-2.60), respectively. IS patients had a higher odds than non-IS patients of in-hospital acute respiratory distress syndrome, heart failure, myocarditis, thromboembolic disease and multiorgan failure.<h4>Conclusions</h4>IS patients hospitalized with COVID-19 have a higher odds of in-hospital complications and death compared to non-IS patients. |
| first_indexed | 2024-12-14T09:16:04Z |
| format | Article |
| id | doaj.art-9bf576b1d91e48e3a6ff63da9ca13570 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T09:16:04Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-9bf576b1d91e48e3a6ff63da9ca135702022-12-21T23:08:27ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01168e025552410.1371/journal.pone.0255524In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain.Inés Suárez-GarcíaIsabel Perales-FraileAndrés González-GarcíaArturo Muñoz-BlancoLuis ManzanoMartín FabregateJesús Díez-ManglanoEva Fonseca AizpuruFrancisco Arnalich FernándezAlejandra García GarcíaRicardo Gómez-HuelgasJosé-Manuel Ramos-RincónSEMI-COVID-19 Network<h4>Background</h4>Whether immunosuppressed (IS) patients have a worse prognosis of COVID-19 compared to non-IS patients is not known. The aim of this study was to evaluate the clinical characteristics and outcome of IS patients hospitalized with COVID-19 compared to non-IS patients.<h4>Methods</h4>We designed a retrospective cohort study. We included all patients hospitalized with laboratory-confirmed COVID-19 from the SEMI-COVID-19 Registry, a large multicentre national cohort in Spain, from March 27th until June 19th, 2020. We used multivariable logistic regression to assess the adjusted odds ratios (aOR) of in-hospital death among IS compared to non-IS patients.<h4>Results</h4>Among 13 206 included patients, 2 111 (16.0%) were IS. A total of 166 (1.3%) patients had solid organ (SO) transplant, 1081 (8.2%) had SO neoplasia, 332 (2.5%) had hematologic neoplasia, and 570 (4.3%), 183 (1.4%) and 394 (3.0%) were receiving systemic steroids, biological treatments, and immunosuppressors, respectively. Compared to non-IS patients, the aOR (95% CI) for in-hospital death was 1.60 (1.43-1.79) for all IS patients, 1.39 (1.18-1.63) for patients with SO cancer, 2.31 (1.76-3.03) for patients with haematological cancer and 3.12 (2.23-4.36) for patients with SO transplant. The aOR (95% CI) for death for patients who were receiving systemic steroids, biological treatments and immunosuppressors compared to non-IS patients were 2.16 (1.80-2.61), 1.97 (1.33-2.91) and 2.06 (1.64-2.60), respectively. IS patients had a higher odds than non-IS patients of in-hospital acute respiratory distress syndrome, heart failure, myocarditis, thromboembolic disease and multiorgan failure.<h4>Conclusions</h4>IS patients hospitalized with COVID-19 have a higher odds of in-hospital complications and death compared to non-IS patients.https://doi.org/10.1371/journal.pone.0255524 |
| spellingShingle | Inés Suárez-García Isabel Perales-Fraile Andrés González-García Arturo Muñoz-Blanco Luis Manzano Martín Fabregate Jesús Díez-Manglano Eva Fonseca Aizpuru Francisco Arnalich Fernández Alejandra García García Ricardo Gómez-Huelgas José-Manuel Ramos-Rincón SEMI-COVID-19 Network In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain. PLoS ONE |
| title | In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain. |
| title_full | In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain. |
| title_fullStr | In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain. |
| title_full_unstemmed | In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain. |
| title_short | In-hospital mortality among immunosuppressed patients with COVID-19: Analysis from a national cohort in Spain. |
| title_sort | in hospital mortality among immunosuppressed patients with covid 19 analysis from a national cohort in spain |
| url | https://doi.org/10.1371/journal.pone.0255524 |
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