Effective Prophylaxis of COVID-19 in Rhesus Macaques Using a Combination of Two Parenterally-Administered SARS-CoV-2 Neutralizing Antibodies

Effective Prophylaxis of COVID-19 in Rhesus Macaques Using a Combination of Two Parenterally-Administered SARS-CoV-2 Neutralizing Antibodies

SARS-CoV-2 is a respiratory borne pathogenic beta coronavirus that is the source of a worldwide pandemic and the cause of multiple pathologies in man. The rhesus macaque model of COVID-19 was utilized to test the added benefit of combinatory parenteral administration of two high-affinity anti-SARS-C...

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Bibliographic Details
Main Authors: Brandon J. Beddingfield, Nicholas J. Maness, Alyssa C. Fears, Jay Rappaport, Pyone Pyone Aye, Kasi Russell-Lodrigue, Lara A. Doyle-Meyers, Robert V. Blair, Ann M. Carias, Patrick J. Madden, Ramon Lorenzo Redondo, Hongmei Gao, David Montefiori, Thomas J. Hope, Chad J. Roy
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
SARS-CoV-2
SARS-CoV-2 antibodies
nonhuman primates
immunoprophylaxis
pharmacokinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.753444/full

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