Night‐to‐night variability in sleep and amyloid beta burden in normal aging
Abstract INTRODUCTION Alzheimer's disease is associated with sleep disturbances and accumulation of cerebral amyloid beta. The objective was to examine whether actigraphy‐detected sleep parameters might be biomarkers for early amyloid burden. METHODS Participants underwent a week of actigraphy...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-07-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/dad2.12460 |
| _version_ | 1797672437476753408 |
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| author | Aurore Jouvencel Marion Baillet Marie Meyer Bixente Dilharreguy Frederic Lamare Karine Pérès Catherine Helmer Jean‐François Dartigues Hélène Amieva Willy Mayo Gwenaëlle Catheline |
| author_facet | Aurore Jouvencel Marion Baillet Marie Meyer Bixente Dilharreguy Frederic Lamare Karine Pérès Catherine Helmer Jean‐François Dartigues Hélène Amieva Willy Mayo Gwenaëlle Catheline |
| author_sort | Aurore Jouvencel |
| collection | DOAJ |
| description | Abstract INTRODUCTION Alzheimer's disease is associated with sleep disturbances and accumulation of cerebral amyloid beta. The objective was to examine whether actigraphy‐detected sleep parameters might be biomarkers for early amyloid burden. METHODS Participants underwent a week of actigraphy and an amyloid positron emission tomography (PET) scan. Sleep duration and continuity disruption (sleep fragmentation and nocturnal awakenings) were extracted and compared between amyloid‐positive and amyloid‐negative participants. Then multiple linear regressions were used between mean or night‐to‐night intra‐individual variability (standard deviation) of sleep parameters and brain amyloid burden in a voxel‐wise analysis. RESULTS Eighty‐six subjects were included (80.3 ± 5.4 years; 48.8% of women). Amyloid‐positive participants had a higher variability of sleep fragmentation compared to amyloid‐negative participants. This parameter was associated with a higher amyloid burden in the frontal and parietal regions, and in the precuneus, in the whole sample. DISCUSSION This study highlights the relevance of using variability in sleep continuity as a potential biomarker of early amyloid pathogenesis. |
| first_indexed | 2024-03-11T21:30:02Z |
| format | Article |
| id | doaj.art-9bf7464c603e4c48b440a541b59d00c5 |
| institution | Directory Open Access Journal |
| issn | 2352-8729 |
| language | English |
| last_indexed | 2024-03-11T21:30:02Z |
| publishDate | 2023-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj.art-9bf7464c603e4c48b440a541b59d00c52023-09-27T11:20:33ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292023-07-01153n/an/a10.1002/dad2.12460Night‐to‐night variability in sleep and amyloid beta burden in normal agingAurore Jouvencel0Marion Baillet1Marie Meyer2Bixente Dilharreguy3Frederic Lamare4Karine Pérès5Catherine Helmer6Jean‐François Dartigues7Hélène Amieva8Willy Mayo9Gwenaëlle Catheline10INCIA, EPHE, Université PSL Univ Bordeaux CNRS BordeauxFranceGIGA‐CRC‐In Vivo Imaging Research Unit University of Liège LiègeBelgiumINCIA, EPHE, Université PSL Univ Bordeaux CNRS BordeauxFranceINCIA, EPHE, Université PSL Univ Bordeaux CNRS BordeauxFranceINCIA, EPHE, Université PSL Univ Bordeaux CNRS BordeauxFranceINSERM Bordeaux Population Health Research Center University of Bordeaux UMR U1219 BordeauxFranceINSERM Bordeaux Population Health Research Center University of Bordeaux UMR U1219 BordeauxFranceINSERM Bordeaux Population Health Research Center University of Bordeaux UMR U1219 BordeauxFranceINSERM Bordeaux Population Health Research Center University of Bordeaux UMR U1219 BordeauxFranceINCIA, EPHE, Université PSL Univ Bordeaux CNRS BordeauxFranceINCIA, EPHE, Université PSL Univ Bordeaux CNRS BordeauxFranceAbstract INTRODUCTION Alzheimer's disease is associated with sleep disturbances and accumulation of cerebral amyloid beta. The objective was to examine whether actigraphy‐detected sleep parameters might be biomarkers for early amyloid burden. METHODS Participants underwent a week of actigraphy and an amyloid positron emission tomography (PET) scan. Sleep duration and continuity disruption (sleep fragmentation and nocturnal awakenings) were extracted and compared between amyloid‐positive and amyloid‐negative participants. Then multiple linear regressions were used between mean or night‐to‐night intra‐individual variability (standard deviation) of sleep parameters and brain amyloid burden in a voxel‐wise analysis. RESULTS Eighty‐six subjects were included (80.3 ± 5.4 years; 48.8% of women). Amyloid‐positive participants had a higher variability of sleep fragmentation compared to amyloid‐negative participants. This parameter was associated with a higher amyloid burden in the frontal and parietal regions, and in the precuneus, in the whole sample. DISCUSSION This study highlights the relevance of using variability in sleep continuity as a potential biomarker of early amyloid pathogenesis.https://doi.org/10.1002/dad2.12460actigraphyagingamyloidintra‐individual variability of sleepPETsleep |
| spellingShingle | Aurore Jouvencel Marion Baillet Marie Meyer Bixente Dilharreguy Frederic Lamare Karine Pérès Catherine Helmer Jean‐François Dartigues Hélène Amieva Willy Mayo Gwenaëlle Catheline Night‐to‐night variability in sleep and amyloid beta burden in normal aging Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring actigraphy aging amyloid intra‐individual variability of sleep PET sleep |
| title | Night‐to‐night variability in sleep and amyloid beta burden in normal aging |
| title_full | Night‐to‐night variability in sleep and amyloid beta burden in normal aging |
| title_fullStr | Night‐to‐night variability in sleep and amyloid beta burden in normal aging |
| title_full_unstemmed | Night‐to‐night variability in sleep and amyloid beta burden in normal aging |
| title_short | Night‐to‐night variability in sleep and amyloid beta burden in normal aging |
| title_sort | night to night variability in sleep and amyloid beta burden in normal aging |
| topic | actigraphy aging amyloid intra‐individual variability of sleep PET sleep |
| url | https://doi.org/10.1002/dad2.12460 |
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