Fenofibrate Interferes with the Diapedesis of Lung Adenocarcinoma Cells through the Interference with Cx43/EGF-Dependent Intercellular Signaling

Fenofibrate Interferes with the Diapedesis of Lung Adenocarcinoma Cells through the Interference with Cx43/EGF-Dependent Intercellular Signaling

Extravasation of circulating cancer cells is regulated by the intercellular/intracellular signaling pathways that locally impair the endothelial barrier function. Co-cultures of human umbilical vein endothelial cells (HUVECs) with lung adenocarcinoma A549 cells enabled us to identify these pathways...

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Bibliographic Details
Main Authors: Katarzyna Piwowarczyk, Edyta Kwiecień, Justyna Sośniak, Eliza Zimoląg, Emiliana Guzik, Jolanta Sroka, Zbigniew Madeja, Jarosław Czyż
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
fenofibrate
lung cancer
diapedesis
Cx43
EGF
Online Access:http://www.mdpi.com/2072-6694/10/10/363

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