A Targeted and Tuneable DNA Damage Tool Using CRISPR/Cas9

A Targeted and Tuneable DNA Damage Tool Using CRISPR/Cas9

Mammalian cells are constantly subjected to a variety of DNA damaging events that lead to the activation of DNA repair pathways. Understanding the molecular mechanisms of the DNA damage response allows the development of therapeutics which target elements of these pathways. Double-strand breaks (DSB...

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Bibliographic Details
Main Authors: Ioannis Emmanouilidis, Natalia Fili, Alexander W. Cook, Yukti Hari-Gupta, Ália dos Santos, Lin Wang, Marisa L. Martin-Fernandez, Peter J. I. Ellis, Christopher P. Toseland
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Biomolecules
Subjects:
DNA damage
Cas9
double-strand break
DNA repair
Online Access:https://www.mdpi.com/2218-273X/11/2/288

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