Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview
Longevity is determined by a number of factors, including genetic, environmental and lifestyle factors. A major factor affecting longevity is the development of degenerative disorders such as cardiovascular disease, diabetes, kidney disease and liver disease, particularly where these occur as co-mor...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/8/2/44 |
| _version_ | 1797764399939715072 |
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| author | David Mantle Iain Hargreaves |
| author_facet | David Mantle Iain Hargreaves |
| author_sort | David Mantle |
| collection | DOAJ |
| description | Longevity is determined by a number of factors, including genetic, environmental and lifestyle factors. A major factor affecting longevity is the development of degenerative disorders such as cardiovascular disease, diabetes, kidney disease and liver disease, particularly where these occur as co-morbidities. In this article, we review the potential role of supplementation with coenzyme Q10 (CoQ10) for the prevention or management of these disorders. Thus, randomised controlled clinical trials have shown supplementation with CoQ10 or CoQ10 plus selenium reduces mortality by approximately 50% in patients with cardiovascular disease, or in the normal elderly population, respectively. Similarly, CoQ10 supplementation improves glycaemic control and vascular dysfunction in type II diabetes, improves renal function in patients with chronic kidney disease, and reduces liver inflammation in patients with non-alcoholic fatty liver disease. The beneficial role of supplemental CoQ10 in the above disorders is considered to result from a combination of its roles in cellular energy generation, as an antioxidant and as an anti-inflammatory agent. |
| first_indexed | 2024-03-12T19:56:07Z |
| format | Article |
| id | doaj.art-9bf967c465ae41f6997ccb5441f3e604 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-12T19:56:07Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-9bf967c465ae41f6997ccb5441f3e6042023-08-02T02:49:46ZengMDPI AGAntioxidants2076-39212019-02-01824410.3390/antiox8020044antiox8020044Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An OverviewDavid Mantle0Iain Hargreaves1Pharma Nord (UK) Ltd., Telford Court, Morpeth, NE61 2DB Northumberland, UKSchool of Pharmacy, Liverpool John Moores University, L3 5UA Liverpool, UKLongevity is determined by a number of factors, including genetic, environmental and lifestyle factors. A major factor affecting longevity is the development of degenerative disorders such as cardiovascular disease, diabetes, kidney disease and liver disease, particularly where these occur as co-morbidities. In this article, we review the potential role of supplementation with coenzyme Q10 (CoQ10) for the prevention or management of these disorders. Thus, randomised controlled clinical trials have shown supplementation with CoQ10 or CoQ10 plus selenium reduces mortality by approximately 50% in patients with cardiovascular disease, or in the normal elderly population, respectively. Similarly, CoQ10 supplementation improves glycaemic control and vascular dysfunction in type II diabetes, improves renal function in patients with chronic kidney disease, and reduces liver inflammation in patients with non-alcoholic fatty liver disease. The beneficial role of supplemental CoQ10 in the above disorders is considered to result from a combination of its roles in cellular energy generation, as an antioxidant and as an anti-inflammatory agent.https://www.mdpi.com/2076-3921/8/2/44coenzyme Q10oxidative stressinflammationdiabetescardiovascular diseasechronic kidney disease and liver diseasemitochondria |
| spellingShingle | David Mantle Iain Hargreaves Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview Antioxidants coenzyme Q10 oxidative stress inflammation diabetes cardiovascular disease chronic kidney disease and liver disease mitochondria |
| title | Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview |
| title_full | Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview |
| title_fullStr | Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview |
| title_full_unstemmed | Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview |
| title_short | Coenzyme Q10 and Degenerative Disorders Affecting Longevity: An Overview |
| title_sort | coenzyme q10 and degenerative disorders affecting longevity an overview |
| topic | coenzyme Q10 oxidative stress inflammation diabetes cardiovascular disease chronic kidney disease and liver disease mitochondria |
| url | https://www.mdpi.com/2076-3921/8/2/44 |
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